Blar i Department of Clinical Science på tittel
Viser treff 163-182 av 2318
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Atypical (non-V600E) BRAF mutations in metastatic colorectal cancer in population and real-world cohorts
(Journal article; Peer reviewed, 2023)BRAF-V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non-V600Emt, designated atypical BRAFmt (aBRAFmt) are rare, and little is known about their frequency, ... -
Augmented CD4+ T-cell and humoral responses after repeated annual influenza vaccination with the same vaccine component A/H1N1pdm09 over 5 years
(Peer reviewed; Journal article, 2018-08-14)Annual seasonal influenza vaccination is recommended for high-risk populations and often occupational groups such as healthcare workers (HCWs). Repeated annual vaccination has been reported to either have no impact or ... -
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
(Journal article; Peer reviewed, 2020)Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease ... -
Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq
(Journal article; Peer reviewed, 2022)Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight ... -
Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies
(Journal article; Peer reviewed, 2023)Objectives: Autoantibodies are thought to play a key role in the pathogenesis of idiopathic inflammatory myopathies (IIM). However, up to 40% of IIM patients, even those with clinical manifestations of anti-synthetase ... -
Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
(Journal article; Peer reviewed, 2023)The emergence of castration-resistant prostate cancer remains an area of unmet clinical need. We recently identified a subpopulation of normal prostate progenitor cells, characterized by an intrinsic resistance to androgen ... -
Autoimmune polyendocrine syndrome type I. Novel diagnostic assays and immune regulation
(Doctoral thesis, 2012-02-10)Autoimmune polyendocrine syndrome type I (APS-I) is a rare, monogenetic recessively inherited disease caused by mutations in the autoimmune regulator (AIRE) gene. The patients display different endocrine and ectodermal ... -
Autoimmune primary adrenal insufficiency – autoantibodies and cell regeneration
(Doctoral thesis, 2024-02-02)Autoimmun primær binyrebarksvikt er en sjelden lidelse som skyldes autoimmun ødeleggelse av binyrebarken, og foreløpig finnes det ingen kurativ behandling. Her undersøkte vi to distinkte aspekter ved sykdommen, en molekylær ... -
Autoimmune Thyroid Disorders in Autoimmune Addison Disease
(Journal article; Peer reviewed, 2022)Context: Autoimmune thyroid disease is the most common endocrine co-morbidity in autoimmune Addison's disease (AAD), but detailed investigations of prevalence and clinical course is lacking. Objective: Provide comprehensive ... -
Autoimmunity and viral immunity in Addison’s disease
(Doctoral thesis, 2015-11-27)Autoimmune Addison’s disease (AAD) is caused by an immunological destruction of the steroid producing cells of the adrenal cortex. Both genetic and environmental factors are involved in disease development, and while ... -
Automatic Estimation of Coronary Blood Flow Velocity Step 1 for Developing a Tool to Diagnose Patients With Micro-Vascular Angina Pectoris
(Peer reviewed; Journal article, 2019-01-22)Aim: Our aim was to automatically estimate the blood velocity in coronary arteries using cine X-ray angiographic sequence. Estimating the coronary blood velocity is a key approach in investigating patients with angina ... -
Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis
(Peer reviewed; Journal article, 2019-06-11)Autotaxin has been associated with liver disease severity and transplant-free survival. This study aimed to validate autotaxin as a biomarker in two cohorts of Norwegian large-duct PSC patients, one discovery panel (n=165) ... -
Autozygosity mapping and time-to-spontaneous delivery in Norwegian parent-offspring trios
(Journal article; Peer reviewed, 2020)Parental genetic relatedness may lead to adverse health and fitness outcomes in the offspring. However, the degree to which it affects human delivery timing is unknown. We use genotype data from ≃25 000 parent-offspring ... -
Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function
(Journal article; Peer reviewed, 2022)Objective: Neonatal lupus erythematosus (NLE) may develop after transplacental transfer of maternal autoantibodies with cardiac manifestations (congenital heart block, CHB) including atrioventricular block, atrial and ... -
Availability of extended-release naltrexone may increase the number of opioid-dependent individuals in treatment: Extension of a randomized clinical trial
(Journal article; Peer reviewed, 2019)Background and objective: Opioid maintenance treatment (OMT) is highly available in Norway, but only 50% of opioid-dependent individuals are enrolled in such programs. This study was aimed at examining if availability of ... -
Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck
(Journal article; Peer reviewed, 2021)Mitochondrial DNA (mtDNA) and plastid DNA (ptDNA) encode vital bioenergetic apparatus, and mutations in these organelle DNA (oDNA) molecules can be devastating. In the germline of several animals, a genetic “bottleneck” ... -
B cell specificity and pattern in primary Sjögren’s syndrome - Studies in humans and a murine model
(Doctoral thesis, 2014-04-30)Sjögren’s syndrome (SS) is a chronic autoimmune disease characterised by focal inflammation of exocrine glands, particularly salivary and lacrimal glands. Here, mononuclear cells, including B cells, infiltrate the glands, ... -
B cells and autoantibodies in AIRE deficiency
(Journal article; Peer reviewed, 2021)Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare but severe monogenetic autoimmune endocrine disease caused by failure of the Autoimmune Regulator (AIRE). AIRE regulates the negative selection of T cells in the ... -
B vitamin and iron status during infancy
(Doctoral thesis, 2015-01-30)Adequate nutrition during infancy is essential to ensure normal growth and development. Since 2001, World Health Organization (WHO) has recommended exclusive breast-feeding for the first 6 months of life, which puts great ... -
B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris
(Peer reviewed; Journal article, 2016-06)Background: Methylenetetrahydrofolate dehydrogenase (MTHFD1) catalyzes three sequential reactions that metabolize derivatives of tetrahydrofolate (THF) in folate-dependent one-carbon metabolism. Impaired MTHFD1 flux has ...