Blar i Department of Clinical Science på tittel
Viser treff 1898-1917 av 2374
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A rat modell to assess interventions to reduce cardiotoxicity of anthracyclines Does pre-treatment with morphine reduce the cardiotoxicity of doxorubicin?
(Master thesis, 2008-05-30)A rat model to assess interventions to reduce cardiotoxicity of anthracyclines is of interest. The model should be able to induce significant myocardial damage rapidly but at the same time allow for measurement of protective ... -
Rationale and design of the Birkebeiner Ageing Study – a prospective cohort study of older endurance athletes
(Journal article; Peer reviewed, 2023)Background While regular physical activity is associated with reduced mortality and morbidity in general populations, health outcomes and functional capacity related to upholding strenuous endurance exercise beyond the ... -
Rationale and design of the PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA II) trial: a randomized, placebo-controlled, multicenter trial
(Journal article, 2021)Background: Recent advances in the treatment algorithms of early breast cancer have markedly improved overall survival. However, anthracycline- and trastuzumab-associated cardiotoxicity may lead to dose-reduction or halt ... -
Re-admission and quality of life among patients with chronic obstructive pulmonary disease after telemedicine video nursing consultation - a randomized study
(Journal article; Peer reviewed, 2023)Background: Our previous study showed a reduced cumulative length of re-admission stays due to chronic obstructive pulmonary disease (COPD) exacerbations during one year after telemedicine video consultation (TVC). The ... -
Re-admissions to hospital and patient satisfaction among patients with chronic obstructive pulmonary disease after telemedicine video consultation - a retrospective pilot study
(Peer reviewed; Journal article, 2014-01-30)Background: Chronic obstructive pulmonary disease (COPD) is a major cause of acute hospital admissions. The main object of our study was to evaluate the effects of telemedicine video-consultation (TVC) on the frequency of ... -
Readmissions and mortality in delirious versus non-delirious octogenarian patients after aortic valve therapy: A prospective cohort study
(Peer reviewed; Journal article, 2016)Objectives: To determine whether postoperative delirium predicts first-time readmissions and mortality in octogenarian patients within 180 days after aortic valve therapy with surgical aortic valve replacement (SAVR) or ... -
Real-world data on niraparib maintenance treatment in patients with non-gBRCA mutated platinum-sensitive recurrent ovarian cancer
(Journal article; Peer reviewed, 2023)Objectives The aim of this study was to provide real-world efficacy and safety data on niraparib maintenance treatment in patients with non-germline (gBRCA)1/2 mutated platinum-sensitive recurrent ovarian cancer. Methods ... -
Recent developments in military transfusion practice and their impact on civilian healthcare
(Doctoral thesis, 2018-05-25)Introduction. Massive haemorrhage is the leading cause of preventable death following trauma. The mortality rate is high unless actively managed from Point of Injury (POI). However, during the last decade advances in ... -
Recently evolved human-specific methylated regions are enriched in schizophrenia signals
(Peer reviewed; Journal article, 2018)Background: One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution. This hypothesis is supported by evidence suggesting that ... -
Recommendations for robust and reproducible preclinical research in personalised medicine
(Journal article; Peer reviewed, 2023)Background Personalised medicine is a medical model that aims to provide tailor-made prevention and treatment strategies for defined groups of individuals. The concept brings new challenges to the translational step, both ... -
Rectal sensitivity correlated with gastrointestinal-mediated glucose disposal, but not the incretin effect
(Journal article; Peer reviewed, 2024)Objective The mechanisms behind the diminished incretin effect in type 2 diabetes are uncertain, but impaired vagal transmission has been suggested. We aimed to investigate the association between the incretin effect ... -
Recurrence of postpartum hemorrhage in relatives: A population-based cohort study
(Journal article; Peer reviewed, 2021)Introduction Studies on the family aggregation of postpartum hemorrhage (PPH) are scarce and with inconsistent results, and to what extent current birthweight influences recurrence between relatives remains to be studied. ... -
Recurrence of postpartum hemorrhage, maternal and paternal contribution, and the effect of offspring birthweight and sex: a population-based cohort study
(Journal article; Peer reviewed, 2022)Purpose: This study examines individual aggregation of postpartum hemorrhage (PPH), paternal contribution and how offspring birthweight and sex influence recurrence of PPH. Further, we wanted to estimate the proportion of ... -
The recurrence pattern following delayed breast reconstruction after mastectomy for breast cancer suggests a systemic effect of surgery on occult dormant micrometastases
(Peer reviewed; Journal article, 2016)The purpose of this study was to characterize the recurrence dynamics in breast cancer patients after delayed reconstruction. We hypothesized that surgical reconstruction might stimulate dormant micrometastases and reduce ... -
Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth
(Peer reviewed; Journal article, 2016-05-10)The estrogen receptor alpha (ERα) is highly expressed in both endometrial and breast cancers, and represents the most prevalent therapeutic target in breast cancer. However, anti-estrogen therapy has not been shown to be ... -
Reduced delays in diagnostic pathways for non-small cell lung cancer after local and National initiatives
(Journal article; Peer reviewed, 2020)Objectives Patients with non-small cell lung cancer (NSCLC) may experience progression and stage shift due to delays in a complex and time-consuming diagnostic work-up. We have analyzed the impact of both a local and ... -
Reduced Endothelial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome–Results From Open-Label Cyclophosphamide Intervention Study
(Journal article; Peer reviewed, 2021)Introduction: Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) present with a range of symptoms including post-exertional malaise (PEM), orthostatic intolerance, and autonomic dysfunction. Dysfunction ... -
Reduced expression of innate immunity-related genes in lymph node metastases of luminal breast cancer patients
(Journal article; Peer reviewed, 2021)Immune system plays a dual role in cancer by either targeting or supporting neoplastic cells at various stages of disease, including metastasis. Yet, the exact immune-related transcriptome profiles of primary tumours (PT) ... -
Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes: the PROLONG study
(Journal article; Peer reviewed, 2021)Type 1 diabetes is a chronic autoimmune disease requiring insulin treatment for survival. Prolonged duration of type 1 diabetes is associated with increased risk of microvascular complications. Although chronic hyperglycemia ... -
Reduced lung function and cause-specific mortality: A population-based study of Norwegian men followed for 26 years
(Journal article; Peer reviewed, 2023)Background and aim Reduced lung function is associated with increased mortality, but it is unclear how different spirometric patterns are related to specific deaths. Aim of this study was to investigate these associations ...