Blar i Department of Clinical Science på tittel
Viser treff 1359-1378 av 2313
-
Managing Contamination and Diverse Bacterial Loads in 16S rRNA Deep Sequencing of Clinical Samples: Implications of the Law of Small Numbers
(Journal article; Peer reviewed, 2021)In this article, we investigate patterns of microbial DNA contamination in targeted 16S rRNA amplicon sequencing (16S deep sequencing) and demonstrate how this can be used to filter background bacterial DNA in diagnostic ... -
Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain
(Journal article; Peer reviewed, 2022)The gene ankyrin-3 (ANK3) has been consistently associated with bipolar disorder (BD) in several genome-wide association studies (GWAS). The exact molecular mechanisms underlying this genetic association remain unknown. ... -
Mapping the human genetic architecture of COVID-19
(Journal article; Peer reviewed, 2021)The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity ... -
Markedsføring av naturmidler- en vurdering
(Master thesis, 2008-06-02)Hensikten med oppgaven var å undersøke og sammenligne markedsføringen av naturmidler i kommunikasjonskanalene apotek, helsekostforretninger, Internett, ukeblad og magasiner. I løpet av ti uker ble det samlet inn annonser, ... -
Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort
(Journal article; Peer reviewed, 2021)Rationale There are no validated measures of disease activity in COPD. Since “active” disease is expected to have worse outcomes (e.g. mortality), we explored potential markers of disease activity in patients enrolled in ... -
Markers of nephropathy in young Fabry disease patients; role of kidney biopsies and functional measurements
(Doctoral thesis, 2013-04-05)Backgound: Fabry disease is an X-linked disease affecting glycosphingolipid metabolism due to deficiency of the lysosomal enzyme α-galactosidase. The natural course of the disease is related to progressive accumulation of ... -
Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery
(Journal article; Peer reviewed, 2022)Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis ... -
Masked hypertension in obesity: Potential predictors and arterial damage
(Peer reviewed; Journal article, 2017-02)Background: Masked hypertension (MHT), defined as normal office blood pressure (BP) but high ambulatory BP, has been associated with increased cardiovascular risk. Although MHT has been associated with obesity, there is ... -
Maternal allergen immunisation to prevent sensitisation in offspring: Th2-polarising adjuvants are more efficient than a Th1-polarising adjuvant in mice
(Peer reviewed; Journal article, 2010-03-01)Background Allergy has been an increasing problem in several parts of the world. Prenatal exposure to allergen and microbial components may affect the development of allergies in childhood, as indicated by epidemiological ... -
Maternal and child gluten intake and association with type 1 diabetes: The Norwegian Mother and Child Cohort Study
(Journal article; Peer reviewed, 2020)Background The relationship between maternal gluten intake in pregnancy, offspring intake in childhood, and offspring risk of type 1 diabetes has not been examined jointly in any studies. Our aim was to study the relationship ... -
Maternal and iatrogenic factors influencing the duration of labour
(Doctoral thesis, 2023-06-22)Bakgrunn: Forlengede fødselsforløp er den fremste grunnen til keisersnitt og operative vaginale forløsninger på verdensbasis. Imidlertid er definisjonen av normal fødselsprogresjon og varighet gjenstand for en pågående ... -
Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring
(Journal article; Peer reviewed, 2021)Background: Studies investigating the effects of prenatal alcohol exposure on childhood attention-deficit hyperactivity disorder (ADHD) symptoms using conventional observational designs have reported inconsistent findings, ... -
Maternal diabetes mellitus and fetal venous liver flow – a longitudinal study
(Doctoral thesis, 2019-06-13)Background: Despite adequate glycemic control, the risks of perinatal complications and fetal macrosomia are increased in pregnancies with pregestational diabetes (PGDM). Maternal overweight, obesity and excess gestational ... -
Maternal influence on fetal size and use of longitudinal fetal surveillance in predicting adverse perinatal outcomes
(Doctoral thesis, 2016-06-15)Background: Fetal growth is influenced by maternal factors, but also more specifically determined by level of fetoplacental circulation. We tested the hypothesis that fetal abdominal circumference (AC) in the second trimester ... -
Maternal microchimerism in cord blood and risk of childhood-onset type 1 diabetes
(Peer reviewed; Journal article, 2019-09)Background: Maternal microchimerism (MMc), the transmission of small quantities of maternal cells to the fetus, is relatively common and persistent. MMc has been detected with increased frequency in the circulation and ... -
Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study
(Journal article; Peer reviewed, 2021)Objective: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with potential effects on offspring both genetically and through altered intrauterine environment. Metformin, which ameliorate hormonal disturbances ... -
Maternal physical activity affects yolk sac size and growth in early pregnancy, but girls and boys use different strategies
(Journal article; Peer reviewed, 2023)This longitudinal study investigated the impact of actigraphy-measured maternal physical activity on yolk sac size during early development. The yolk sac, a transient extraembryonic organ, plays a crucial role in embryonic ... -
Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero
(Peer reviewed; Journal article, 2016-11-25)Background: Children exposed to maternal smoking during pregnancy exhibit increased risk for many adverse health effects. Maternal smoking influences methylation in newborns at specific CpG sites (CpGs). Here, we extend ... -
Matrix M Adjuvanted H5N1 Vaccine Elicits Broadly Neutralizing Antibodies and Neuraminidase Inhibiting Antibodies in Humans That Correlate With In Vivo Protection
(Journal article; Peer reviewed, 2021)The highly pathogenic avian influenza H5N1 viruses constantly evolve and give rise to novel variants that have caused widespread zoonotic outbreaks and sporadic human infections. Therefore, vaccines capable of eliciting ... -
Matrix M H5N1 vaccine induces cross-H5 clade humoral immune responses in a randomized clinical trial and provides protection from highly pathogenic influenza challenge in ferrets
(Peer reviewed; Journal article, 2015-07-06)Background and Methods: Highly pathogenic avian influenza (HPAI) viruses constitute a pandemic threat and the development of effective vaccines is a global priority. Sixty adults were recruited into a randomized clinical ...