Blar i Department of Clinical Science på tittel
Viser treff 1409-1428 av 2313
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Microbiological and bioinformatics analysis of primary Sjogren's syndrome patients with normal salivation
(Peer reviewed; Journal article, 2016-10-20)Background: Reduced salivation is considered a major clinical feature of most but not all cases of primary Sjögren’s syndrome (pSS). Reduced saliva flow may lead to changes in the salivary microbiota. These changes have ... -
Microheterogeneity and preanalytical stability of protein biomarkers of inflammation and renal function
(Journal article; Peer reviewed, 2021)Protein biomarker microheterogeneity has attracted increasing attention in epidemiological and clinical research studies. Knowledge concerning the preanalytical stability of proteins is paramount to assess the biological ... -
Micronutrients in paediatric Intestinal Failure Patients receiving home parenteral nutrition
(Journal article; Peer reviewed, 2020-11)Background & aims Children with intestinal failure (IF) receive parental nutrition to ensure adequate growth and development. The aim of this study was to assess micronutrient status in paediatric IF patients receiving ... -
A MicroRNA Linking Human Positive Selection and Metabolic Disorders
(Journal article; Peer reviewed, 2020)Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also ... -
MicroRNA serum profiles and chronic graft-versus-host disease
(Journal article; Peer reviewed, 2022)Chronic graft-versus-host disease (cGVHD) is the most common long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). During the last decade, the interest of micro RNAs (miRNAs) in the ... -
MicroRNAs enrichment in GWAS of complex human phenotypes
(Peer reviewed; Journal article, 2015-04-16)Background: The genotype information carried by Genome-wide association studies (GWAS) seems to have the potential to explain more of the ‘missing heritability’ of complex human phenotypes, given improved statistical ... -
miR-486-5p expression is regulated by DNA methylation in osteosarcoma
(Journal article; Peer reviewed, 2022)Background Osteosarcoma is the most common primary malignant tumour of bone occurring in children and young adolescents and is characterised by complex genetic and epigenetic changes. The miRNA miR-486-5p has been shown ... -
Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value
(Journal article; Peer reviewed, 2022)Background The endometrial cancer mismatch repair (MMR) deficient subgroup is defined by loss of MSH6, MSH2, PMS2 or MLH1. We compare MMR status in paired preoperative and operative samples and investigate the prognostic ... -
A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
(Peer reviewed; Journal article, 2019-09-24)A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine ... -
Mitral annular dynamics are influenced by left ventricular load and contractility in an acute animal model
(Journal article; Peer reviewed, 2023)The purpose of this study was to investigate the effects of loading conditions and left ventricular (LV) contractility on mitral annular dynamics. In 10 anesthetized pigs, eight piezoelectric transducers were implanted ... -
Mixed Effect Modeling of Dose and Linear Energy Transfer Correlations With Brain Image Changes After Intensity Modulated Proton Therapy for Skull Base Head and Neck Cancer
(Journal article; Peer reviewed, 2021)Purpose Intensity modulated proton therapy (IMPT) could yield high linear energy transfer (LET) in critical structures and increased biological effect. For head and neck cancers at the skull base this could potentially ... -
Modeling assortative mating and genetic similarities between partners, siblings, and in-laws
(Journal article; Peer reviewed, 2022)Assortative mating on heritable traits can have implications for the genetic resemblance between siblings and in-laws in succeeding generations. We studied polygenic scores and phenotypic data from pairs of partners ... -
Modeling psychiatric disorders: From genomic findings to cellular phenotypes
(Peer reviewed; Journal article, 2016)Major programs in psychiatric genetics have identified >150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly ... -
Modes of e-Health delivery in secondary prevention programmes for patients with coronary artery disease: A systematic review
(Peer reviewed; Journal article, 2019-06-10)Background: Electronic health (e-Health) interventions are emerging as an effective alternative model for improving secondary prevention of coronary artery disease (CAD). The aim of this study was to describe the effectiveness ... -
Modulating Wnt signaling in human induced pluripotent stem cell-derived S7 cells
(Peer reviewed; Journal article, 2019)Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ... -
Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia
(Peer reviewed; Journal article, 2019)Purpose. Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, ... -
Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A
(Journal article; Peer reviewed, 2023-01-19)Diabetes is a metabolic disease that currently affects nearly half a billion people worldwide. β-cells dysfunction is one of the main causes of diabetes. Exposure to endocrine-disrupting chemicals is correlated with increased ... -
Molecular alterations suggesting new treatment strategies in uterine carcinomas
(Doctoral thesis, 2017-11-10) -
Molecular and phenotypic characteristics influencing the degree of cytoreduction in high-grade serous ovarian carcinomas
(Journal article; Peer reviewed, 2023)Background: High-grade serous ovarian carcinoma (HGSOC) is the deadliest ovarian cancer subtype, and survival relates to initial cytoreductive surgical treatment. The existing tools for surgical outcome prediction remain ... -
Molecular Biomarkers in Thyroid Eye Disease: A Literature Review
(Journal article; Peer reviewed, 2023)Purpose: Thyroid eye disease (TED) is the most common extrathyroidal manifestation of Graves disease. Patients may be severely affected with eyelid retraction, exophthalmos, diplopia, pain, and threatened vision. ...