Browsing Department of Clinical Science by Title

Now showing items 1809-1828 of 2395

    • Pregnancy Outcome in Women With APECED (APS-1): A Multicenter Study on 43 Females With 83 Pregnancies 

      Laakso, Saila; Hopolainen, Elina; Betterle, Corrado; Saari, Viivi; Vogt, Elinor Margrethe Chelsom; Schmitt, Monica M; Winer, Karen K.; Kareva, Maria A.; Sabbadin, Chiara; Husebye, Eystein Sverre; Orlova, Elizaveta; Lionakis, Michail; Makitie, Outi (Journal article; Peer reviewed, 2022)
      Context Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED; also known as autoimmune polyendocrine syndrome type 1) has a severe, unpredictable course. Autoimmunity and disease components may affect ...

    • Prehospital Whole Blood Transfusion Programs in Norway 

      Bjerkvig, Christopher Kalhagen; Strandenes, Geir; Hervig, Tor; Sunde, Geir Arne; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2021)
      Background: Prehospital management of severe hemorrhage has evolved significantly in Norwegian medical emergency services in the last 10 years. Treatment algorithms for severe bleeding were previously focused on restoration ...

    • Preliminary investigation of Herniaria incana Lam. Determination of the total flavonoid content, antioxidant properties and free radical scavenging capacity. 

      Parmer, Signe Mathea (Master thesis, 2012-05-20)
      In traditional medicine, herbs with antioxidant properties have been used to treat various conditions. Promising results of antioxidant capacity, may suggest that further investigations might lead to development of new ...

    • Prematur ovarialinsuffisiens 

      Vogt, Elinor Margrethe Chelsom; Russell, Hannah Ni Bhriain; Øksnes, Marianne; Lund, Agnethe (Journal article; Peer reviewed, 2022)
      Prematur ovarialinsuffisiens defineres som tap av ovariefunksjon før 40 års alder og er en kompleks tilstand med heterogen etiologi. Tidlig diagnose og igangsetting av hormonerstattende behandling er viktig for å lindre ...

    • Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts 

      Vogt, Elinor Margrethe Chelsom; Real, Francisco Gomez; Husebye, Eystein Sverre; Björnsdottir, Sigridur; Benediktsdottir, Bryndis; Bertelsen, Randi Jacobsen; Demoly, Pascal; Franklin, Karl Anders; Gallastegui, Leire Sainz de Aja; González, Francisco Javier Callejas; Heinrich, Joachim; Holm, Mathias; Jögi, Nils Oskar; Leynaert, Benedicte; Lindberg, Eva; Malinovschi, Andrei; Martínez-Moratalla, Jesús; Mayoral, Raúl Godoy; Oudin, Anna; Pereira-Vega, Antonio; Semjen, Chantal Raherison; Schlünssen, Vivi; Triebner, Kai Philipp; Øksnes, Marianne (Journal article; Peer reviewed, 2022)
      Objective: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women. Design: Postmenopausal women were categorized ...

    • Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development 

      Nikolaienko, Oleksii; Eikesdal, Hans Petter; Berge, Elisabet Ognedal; Gilje, Bjørnar; Lundgren, Steinar; Blix, Egil Støre; Espelid, Helge; Geisler, Jürgen; Geisler, Stephanie; Janssen, Emiel; Yndestad, Synnøve; Minsaas, Laura; Leirvaag, Beryl; Lillestøl, Reidun Kristine; Knappskog, Stian; Lønning, Per Eystein (Journal article; Peer reviewed, 2023)
      Background Normal cell BRCA1 epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 epimutations as their underlying cause is ...

    • Prenatal dexamethasone treatment for classic 21-hydroxylase deficiency in Europe 

      Nowotny, Hanna; Neumann, Uta; Tardy-Guidollet, Veronique; Faisal Ahmed, Ahmed; Baronio, Federico; Battelino, Tadej; Bertherat, Jerome; Blankenstein, Oliver; Bonomi, Marco; Bouvattier, Claire; De la Perrière, Aude Brac; Brucker, Sara; Cappa, Marco; Chanson, Philippe; Van der Grinten, Hedi L. Claahsen; Colao, Annamaria; Cools, Martine; Davies, Justin H.; Dorr, Helmut-Gunther; Fenske, Wiebke K.; Ghigo, Ezio; Giordano, Roberta; Gravholt, Claus H.; Huebner, Angela; Husebye, Eystein Sverre; Igbokwe, Rebecca; Juul, Anders; Kiefer, Florian W.; Leger, Juliane; Menassa, Rita; Meyer, Gesine; Neocleous, Vassos; Phylactou, Leonidas A.; Rohayem, Julia; Russo, Gianni; Scaroni, Carla; Touraine, Philippe; Unger, Nicole; Vojtkova, Jarmila; Yeste, Diego; Lajic, Svetlana; Reisch, Nicole (Journal article; Peer reviewed, 2022)
      Objective: To assess the current medical practice in Europe regarding prenatal dexamethasone (Pdex) treatment of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Design and methods: A questionnaire ...

    • Prenatal iron exposure and childhood type 1 diabetes 

      Størdal, Ketil; McArdle, Harry J.; Hayes, Helen; Tapia, German; Viken, Marte K; Lund-Blix, Nicolai Andre; Haugen, Margaretha; Joner, Geir; Skrivarhaug, Torild; Mårild, Karl Staffan; Njølstad, Pål Rasmus; Eggesbø, Merete Åse; Mandal, Siddhartha; Page, Christian; London, Stephanie J.; Lie, Benedicte Alexandra; Stene, Lars Christian Mørch (Peer reviewed; Journal article, 2018-06-13)
      Iron overload due to environmental or genetic causes have been associated diabetes. We hypothesized that prenatal iron exposure is associated with higher risk of childhood type 1 diabetes. In the Norwegian Mother and Child ...

    • Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer 

      Lombaers, Marike S.; Cornel, Karlijn M. C.; Visser, Nicole C. M.; Bulten, Johan; Küsters-Vandevelde, Heidi V. N.; Amant, Frédéric; Boll, Dorry; Bronsert, Peter; Colas, Eva; Geomini, Peggy M. A. J.; Gil-Moreno, Antonio; van Hamont, Dennis; Huvila, Jutta; Krakstad, Camilla; Kraayenbrink, Arjan A.; Koskas, Martin; Mancebo, Gemma; Matías-Guiu, Xavier; Ngo, Huy; Pijlman, Brenda M.; Vos, Maria Caroline; Weinberger, Vit; Snijders, Marc P. L. M.; van Koeverden, Sebastiaan W.; Haldorsen, Ingfrid S.; Reijnen, Casper; Pijnenborg, Johanna M. A. (Journal article; Peer reviewed, 2023)
      Patients with high-grade endometrial carcinoma (EC) have an increased risk of tumor spread and lymph node metastasis (LNM). Preoperative imaging and CA125 can be used in work-up. As data on cancer antigen 125 (CA125) in ...

    • Preoperative risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model: A development and validation study 

      Reijnen, Casper; Gogou, Evangelia; Visser, Nicole C.M.; Engerud, Hilde; Ramjith, Jordache; Van Der Putten, Louis J.M.; Van De Vijver, Koen; Santacana, Maria; Bronsert, Peter; Bulten, Johan; Hirschfeld, Marc; Colas, Eva; Gil-Moreno, Antonio; Reques, Armando; Mancebo, Gemma; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Bednarikova, Marketa; Hausnerova, Jitka; Van Der Wurff, Anneke A. M.; Matias-Guiu, Xavier; Amant, Frédéric; Massuger, Leon F.A.G.; Snijders, Marc P.L.M.; Küsters-Vandevelde, Heidi V.N.; Lucas, Peter J. F.; Pijnenborg, Johanna M.A. (Journal article; Peer reviewed, 2020)
      Background Bayesian networks (BNs) are machine-learning–based computational models that visualize causal relationships and provide insight into the processes underlying disease progression, closely resembling clinical ...

    • Presence and effect of tumour biomarkers in a population-based series of metastatic colorectal cancer patients 

      Aasebø, Kristine Øverås (Doctoral thesis, 2021-10-22)
      Background: Colorectal cancer (CRC) is one of the most common malignancies worldwide, and a substantial group of patients will develop metastases. Survival for metastatic CRC (mCRC) has improved, but mainly for trial ...

    • Presence of interferon-λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus 

      Waldenström, Jesper; Hellstrand, Kristoffer; Westin, Johan; Nilsson, Staffan; Christensen, Peer; Färkkilä, Martti; Mørch, Kristine; Langeland, Nina; Norkrans, Gunnar; Lagging, Martin (Journal article; Peer reviewed, 2021)
      Objectives Despite recombinant interferon-λ 4 (IFN-λ4) demonstrating anti-viral activity in vitro and the ancestral functional gene (IFNL4) being conserved in all other primates, there has been speculation that IFN-λ4 may ...

    • Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients 

      Hatfield, Kimberley Joanne; Bruserud, Øystein; Reikvam, Håkon (Journal article; Peer reviewed, 2022-06-13)
      Allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies. However, this treatment is associated with severe treatment-related morbidity and mortality. The metabolic status of ...

    • Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality 

      Reikvam, Håkon; Bruserud, Øystein; Hatfield, Kimberley Joanne (Journal article; Peer reviewed, 2023)
      Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is used in the treatment of high-risk acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS); however, the treatment has high risk of severe ...

    • Prevalence and antimicrobial resistance of microbes causing bloodstream infections in Unguja, Zanzibar 

      Onken, Annette; Aboud, Said; Jørstad, Melissa Davidsen; Jenum, Pål; Blomberg, Bjørn (Journal article; Peer reviewed, 2015)
      Background: Bloodstream infections (BSI) are frequent and cause high case-fatality rates. Urgent antibiotic treatment can save patients’ lives, but antibiotic resistance can render antibiotic therapy futile. This study is ...

    • Prevalence and assemblage of Giardia duodenalis in a case-control study of children under 5 years from Jimma, Southwest Ethiopia 

      Alemu, Yonas; Abdissa, Alemseged; Mekonnen, Zeleke; Sharew, Bizuwarek; Johansen, Øystein Haarklau; Bjørang, Ola; Langeland, Nina; Hanevik, Kurt; Moyo, Sabrina John (Journal article; Peer reviewed, 2023)
      Giardia duodenalis is a common pathogenic intestinal protozoan parasite with high prevalence in developing countries, especially among children. The distribution of giardia assemblages among humans and their clinical ...

    • Prevalence and causes of loss of consciousness in former North Sea occupational divers 

      Sundal, Endre; Irgens, Ågot; Troland, Kari; Thorsen, Einar; Grønning, Marit (Peer reviewed; Journal article, 2013)
      Background: Loss of consciousness (LOC) is a serious event during diving. The purpose of this study wasto estimate the prevalence and causes of LOC during diving in former North Sea divers, and the impacton health-related ...

    • The prevalence and clinical relevance of hyperhomocysteinemia suggesting vitamin B12 deficiency in presumed healthy infants 

      Ljungblad, Ulf Wike; Paulsen, Henriette; Mørkrid, Lars; Pettersen, Rolf Dagfinn; Hager, Helle Borgstrøm; Lindberg, Morten; Astrup, Henriette; Eklund, Erik A.; Monsen, Anne-Lise Bjørke; Rootwelt-Revheim, Terje; Tangeraas, Trine (Journal article; Peer reviewed, 2021)
      Background Previous studies have demonstrated a high prevalence of biochemical vitamin B12 deficiency in infants in Norway. Increased total homocysteine (tHcy) is the most important marker of B12 deficiency in infants. ...

    • Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort 

      Hansen, Susanne; von Bülow, Anna; Sandin, Patrik; Ernstsson, Olivia; Janson, Christer; Lehtimäki, Lauri; Kankaanranta, Hannu; Ulrik, Charlotte; Aarli, Bernt Bøgvald; Wahl, Hanna Fues; Geale, Kirk; Tang, Sheila Tuyet; Wolf, Maija; Larsen, Tom; Altraja, Alan; Backmann, Helena; Kilpeläinen, Maritta; Viinanen, Arja; Ludviksdottir, Dora; Kauppi, Paula; Sverrild, Asger; Lehmann, Sverre; Backer, Vibeke; Yasinska, Valentyna; Skjold, Tina; Karjalainen, Jussi; Bossios, Apostolos; Porsbjerg, Celeste (Journal article; Peer reviewed, 2023)
      Background Real-life evidence on prevalence and management of severe asthma is limited. Nationwide population registries across the Nordic countries provide unique opportunities to describe prevalence and management patterns ...

    • Prevalence and molecular characterisation of human adenovirus in diarrhoeic children in Tanzania; a case control study 

      Moyo, Sabrina John; Hanevik, Kurt; Blomberg, Bjørn; Kommedal, Øyvind; Nordbø, Svein Arne; Maselle, Samuel Y; Langeland, Nina (Peer reviewed; Journal article, 2014-12-12)
      Background: Human adenovirus (HAdV) causes acute diarrhoea sporadically, as well as in outbreaks. Understanding the prevalence and types of HAdV in diarrhoea is important for control and preventive measures, especially in ...