Blar i Department of Clinical Science på tittel

Viser treff 1918-1937 av 2313

    • Respiratory symptoms in adults are related to impaired quality of life, regardless of asthma and COPD: results from the European community respiratory health survey 

      Voll-Aanerud, Marianne; Eagan, Tomas Mikal; Plana, Estel; Omenaas, Ernst; Bakke, Per; Svanes, Cecilie; Siroux, Valerie; Pin, Isabelle; Antó, Josep M.; Leynaert, Benedicte (Peer reviewed; Journal article, 2010-09-27)
      Background Respiratory symptoms are common in the general population, and their presence is related to Health-related quality of life (HRQoL). The objective was to describe the association of respiratory symptoms with HRQoL ...

    • Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency 

      Campbell, Tessa Mollie; Liu, Zhiyong; Zhang, Qian; Moncada-Velez, Marcela; Covill, Laura E.; Zhang, Peng; Darazam, Ilad Alavi; Bastard, Paul; Bizien, Lucy; Bucciol, Giorgia; Enoksson, Sara Lind; Jouanguy, Emmanuelle; Karabela, Şemsi Nur; Khan, Taushif; Kendir-Demirkol, Yasemin; Arias, Andres Augusto; Mansouri, Davood; Marits, Per; Marr, Nico; Migeotte, Isabelle; Moens, Leen; Ozcelik, Tayfun; Pellier, Isabelle; Sendel, Anton; Senoglu, Sevtap; Shahrooei, Mohammad; Edvard Smith, Smith; Vandernoot, Isabelle; Willekens, Karen; Yasar, Kadriye Kart; Bergman, Peter; Abel, Laurent; Cobat, Aurélie; Casanova, Jean-Laurent; Meyts, Isabelle; Bryceson, Yenan (Journal article; Peer reviewed, 2022)
      Autosomal recessive IRF7 deficiency was previously reported in three patients with single critical influenza or COVID-19 pneumonia episodes. The patients’ fibroblasts and plasmacytoid dendritic cells produced no detectable ...

    • The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease 

      van Rijn, Anneloes L.; van Boheemen, Sander; Sidorov, Igor; Carbo, Ellen C.; Pappas, Nikos; Mei, Hailiang; Feltkamp, Mariet; Aanerud, Marianne; Bakke, Per S.; Claas, Eric C.J.; Eagan, Tomas Mikal; Hiemstra, Pieter S.; Kroes, Aloys C.M.; de Vries, Jutte J.C. (Peer reviewed; Journal article, 2019-10-24)
      Introduction: Exacerbations are major contributors to morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD), and respiratory bacterial and viral infections are an important trigger. However, ...

    • Responsiveness to influenza vaccination correlates with NKG2C-expression on NK cells 

      Riese, Peggy; Trittel, Stephanie; Pathirana, Rishi; Klawonn, Frank; Cox, Rebecca Jane; Guzmán, Carlos A. (Journal article; Peer reviewed, 2020-06-05)
      Influenza vaccination often results in a large percentage of low responders, especially in high-risk groups. As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. However, ...

    • Resting heart rate, self-reported physical activity in middle age, and long-term risk of hip fracture. A NOREPOS cohort study of 367,386 men and women 

      Landgraff, Ida Kalstad; Meyer, Haakon Eduard; Ranhoff, Anette Hylen; Holvik, Kristin; Talsnes, Ove; Myrstad, Marius (Journal article; Peer reviewed, 2023)
      Enhanced knowledge regarding modifiable risk factors for hip fractures are warranted. We aimed to study the associations between two indicators of physical fitness (resting heart rate and level of physical activity) in ...

    • A restrictive policy for red blood cell transfusion in older hip fracture patients: experiences from a patient register 

      Martinsen, Mette; Valland, Haldor; Solheim, Ludvig Fjeld; Holvik, Kristin; Ranhoff, Anette Hylen (Peer reviewed; Journal article, 2016-02-09)
      Background: Allogeneic red blood cell transfusions (ABT) are common in older hip fracture patients. Recent research supports a restrictive transfusion policy. The aim was to study variation in hemoglobin (Hb) concentration, ...

    • Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease 

      Stiglund, Natalie; Strand, Kristina; Cornillet, Martin; Stål, Per; Thorell, Anders; Zimmer, Christine L.; Näslund, Erik; Karlgren, Silja; Nilsson, Henrik; Mellgren, Gunnar; Fernø, Johan; Hagström, Hannes; Björkström, Niklas K. (Peer reviewed; Journal article, 2019-06-04)
      Non-alcoholic fatty liver disease (NAFLD), and the progressive stage non-alcoholic steatohepatitis (NASH), is the predominant cause of chronic liver disease globally. As part of the complex pathogenesis, natural killer ...

    • Retention Time and Fragmentation Predictors Increase Confidence in Identification of Common Variant Peptides 

      Skiadopoulou, Dafni; Vasicek, Jakub; Kuznetsova, Ksenia; Bouyssié, David; Käll, Lukas; Vaudel, Marc (Journal article; Peer reviewed, 2023)
      Precision medicine focuses on adapting care to the individual profile of patients, for example, accounting for their unique genetic makeup. Being able to account for the effect of genetic variation on the proteome holds ...

    • “Rethinking High-Grade Serous Carcinoma: Development of new tools for deep tissue profiling” 

      Anandan, Shamundeeswari (Doctoral thesis, 2021-09-03)
      Background: High-grade serous ovarian cancer (HGSOC) is the most frequently occurring and most fatal epithelial ovarian cancer (EOC) subtype. The reciprocal interplay of the different components encompassed within the ...

    • Rethinking High-Grade Serous Ovarian Carcinoma: Comprehensive Bioprofiling for Enhanced Identification of Surgical Phenotypes and Treatment Outcomes 

      Torkildsen, Cecilie Fredvik (Doctoral thesis, 2023-09-26)
      Bakgrunn: Til tross for betydelige fremskritt innenfor medisinsk og kirurgisk behandling er prognosen for høygradig serøs ovarialcarcinom (HGSOC) fremdeles dårlig. Kirurgi er sentralt for behandlingen, og fjerning av alle ...

    • Rethinking rehabilitation after percutaneous coronary intervention: a protocol of a multicentre cohort study on continuity of care, health literacy, adherence and costs at all care levels (the CONCARDPCI) 

      Norekvål, Tone Merete; Allore, Heather G; Bendz, Bjørn; Bjorvatn, Cathrine; Borregaard, Britt; Brørs, Gunhild; Deaton, Christi; Fålun, Nina Britt; Hadjistavropoulos, Heather; Hansen, Tina Birgitte; Igland, Stig; Larsen, Alf Inge; Palm, Pernille; Pettersen, Trond Røed; Rasmussen, Trine Bernholdt; Schjøtt, Jan; Søgaard, Rikke; Valaker, Irene; Zwisler, Ann Dorthe; Rotevatn, Svein (Journal article; Peer reviewed, 2020)
      Introduction Percutaneous coronary intervention (PCI) aims to provide instant relief of symptoms, and improve functional capacity and prognosis in patients with coronary artery disease. Although patients may experience ...

    • A retrospective comparison of inappropriate prescribing of psychotropics in three Norwegian nursing homes in 2000 and 2016 with prescribing quality indicators 

      Schjøtt, Jan; Assmus, Jörg (Peer reviewed; Journal article, 2019)
      Background: Inappropriate prescribing of psychotropics is a persistent and prevalent problem in nursing homes. The present study compared inappropriate prescribing of psychotropics in nursing homes 16 years apart with ...

    • Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples 

      Bailey, Matthew H.; Meyerson, William U.; Dursi, L. Jonathan; Wang, Liang-Bo; Dong, Guanlan; Liang, Wen-Wei; Weerasinghe, Amila; Li, Shantao; Li, Yize; Kelso, Sean; Aure, Miriam Ragle; Børresen-Dale, Anne-Lise; Langerød, Anita; Baumhoer, Daniel; Bjerkehagen, Bodil; Garred, Øystein; Lingjærde, Ole Christian; Sauer, Torill; Zaikova, Olga; Myklebost, Ola; Knappskog, Stian; Vazquez, Miguel; Akbani, Rehan; Anur, Pavana; Buchanan, Alex; Chiotti, Kami; Covington, Kyle; Creason, Allison; Niu, Beifang; Bieg, Matthias; Boutros, Paul C.; Buchhalter, Ivo; Butler, Adam P.; Chen, Ken; Chong, Zechen; Drechsel, Oliver; Aaltonen, Lauri; Abascal, Federico; Abeshouse, Adam; Aburatani, H; Adams, David J.; Van Loo, Peter; Saksena, Gordon; Ellrott, Kyle; Wendl, Michael C.; Wheeler, David A.; Getz, Gad; Simpson, Jared T.; Gerstein, Mark B.; Ding, Li (Journal article; Peer reviewed, 2020)
      The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part ...

    • Return to work after coronary artery bypass grafting and aortic valve replacement surgery: A scoping review 

      Mortensen, Michael André Helnes; Sandvik, Reidun Karin Norheim Myhre; Svendsen, Øyvind Sverre; Haaverstad, Rune; Moi, Asgjerd Litlere (Journal article; Peer reviewed, 2021)
      Background Coronary artery bypass grafting surgery and aortic valve replacement surgery are essential treatment options for people suffering from angina pectoris or aortic valve disease. Surgery aims to prolong life ...

    • Revealing missing human protein isoforms based on Ab initio prediction, RNA-seq and proteomics 

      Hu, Zhiqiang; Scott, Hamish S.; Qin, Guangrong; Zheng, Guangyong; Chu, Xixia; Xie, Lu; Adelson, David L.; Oftedal, Bergithe Eikeland; Venugopal, Parvathy; Babic, Milena; Hahn, Christopher N.; Zhang, Bing; Wang, Xiaojing; Li, Nan; Wei, Chaochun (Peer reviewed; Journal article, 2015-07-09)
      Biological and biomedical research relies on comprehensive understanding of protein-coding transcripts. However, the total number of human proteins is still unknown due to the prevalence of alternative splicing. In this ...

    • Review of Clinical Questions Submitted to Norwegian Drug Information Centres Concerning Administration and Dosage to Older Patients of Relevance to Patient-Centric Care 

      Schjøtt, Jan; Andreassen, Lillan Mo; Dale, Gro Helen; Stokes, Charlotte L. (Journal article; Peer reviewed, 2021)
      Patient-centric care entails optimising healthcare provision to patients based on their perspective and opinion. It involves appropriate treatment at a reasonable cost and a focus on patient characteristics in the ...

    • Revisiting the prognostic role of FLT3 mutations in acute myelogenous leukemia 

      Reikvam, Håkon (Journal article; Peer reviewed, 2023)
      Introduction: Approximately one-third of patients with acute myelogenous leukemia (AML) harbor mutations in the fms-like tyrosine kinase 3 (FLT3) gene. The features regarding prognostic impact of FLT3 mutated AML have been ...

    • The Rho GTPase RND3 regulates adipocyte lipolysis 

      Dankel, Simon N; Røst, Therese Halvorsen; Kulyté, Agné; Fandalyuk, Zinayida; Skurk, Thomas; Hauner, Hans; Sagen, Jørn V.; Rydén, Mikael; Arner, Peter; Mellgren, Gunnar (Peer reviewed; Journal article, 2019)
      Background: Adipose tissue plays a crucial role in diet- and obesity-related insulin resistance, with implications for several metabolic diseases. Identification of novel target genes and mechanisms that regulate adipocyte ...

    • Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency 

      Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Peer reviewed; Journal article, 2019-01-17)
      Common variable immunodefciency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic infammation and ten “key” bacteria ...

    • Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial 

      Awoyemi, Ayodeji Olawale; Mayerhofer, Cristiane; Felix, Alex S.; Hov, Johannes Espolin Roksund; Moscavitch, Samuel D.; Lappegård, Knut Tore; Hovland, Anders; Halvorsen, Sigrun; Halvorsen, Bente; Gregersen, Ida; Svardal, Asbjørn M.; Berge, Rolf Kristian; Hansen, Simen Hyll; Götz, Alexandra; Holm, Kristian; Aukrust, Pål; Åkra, Sissel; Seljeflot, Ingebjørg; Solheim, Svein; Lorenzo, Andrea; Gullestad, Lars; Trøseid, Marius; Broch, Kaspar (Journal article; Peer reviewed, 2021)
      Background The gut microbiota represents a potential treatment target in heart failure (HF) through microbial metabolites such as trimethylamine N-oxide (TMAO) and systemic inflammation. Treatment with the probiotic yeast ...