Blar i Department of Clinical Science på tittel
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Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation
(Journal article; Peer reviewed, 2021)Background and Aims: Altered bile acid (BA) homeostasis is an intrinsic facet of cholestatic liver diseases, but clinical usefulness of plasma BA assessment in primary sclerosing cholangitis (PSC) remains understudied. We ... -
Bimodal expression of potential drug target CLL-1 (CLEC12A) on CD34+ blasts of AML patients
(Journal article; Peer reviewed, 2021)Objectives This study aims to retrospectively assess C-lectin-like molecule 1 (CLL-1) bimodal expression on CD34+ blasts in acute myeloid leukemia (AML) patients (total N = 306) and explore potential CLL-1 bimodal ... -
Bioactive fatty acids and coronary heart disease. Mechanisms and clinical effects of dietary fatty acids
(Doctoral thesis, 2013-06-26)Background: A high intake of omega-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFAs), which are potential peroxisome proliferator-activated receptor (PPAR) agonists, has been associated with proposed favourable ... -
Bioactive peptides from microalgae: Focus on anti-cancer and immunomodulating activity
(Journal article; Peer reviewed, 2021)In addition to the rapidly expanding field of using microalgae for food and feed, microalgae represent a tremendous potential for new bioactive compounds with health-promoting effects. One field where new therapeutics is ... -
Biofilm and planktonic lifestyles of Porphyromonas gingivalis and Fusobacterium nucleatum. Proteomic analysis of bacteria grown as planktonic cells, mono- and dual species biofilm, and characterization of the biofilm extracellular polymeric matrix’
(Doctoral thesis, 2018-04-06)Periodontitis is one of the most prevalent infectious diseases affecting humans. Periodontitis leads to the destruction of the dental support tissues, which in the terminal stage causes loss of teeth. Periodontitis is ... -
Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation
(Journal article; Peer reviewed, 2020)Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular ... -
Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes
(Peer reviewed; Journal article, 2011-07-12)One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation. OCM dysfunction has been associated with increased risk for various diseases, including cancer and neural ... -
The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
(Journal article; Peer reviewed, 2020)High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. ... -
Biological mechanisms for chronic fatigue in primary Sjøgren`s syndrome
(Doctoral thesis, 2012-06-15)Background: Primary Sjøgren`s syndrome (pSS) is a chronic autoimmune disease, characterised by lymphocytic infiltration of exocrine glands and autoantibody production. Fatigue is a frequent phenomenon in pSS, associated ... -
Biological variation of cardiac myosin-binding protein C in healthy individuals
(Journal article; Peer reviewed, 2021)Objectives Cardiac myosin-binding protein C (cMyC) is a novel biomarker of myocardial injury, with a promising role in the triage and risk stratification of patients presenting with acute cardiac disease. In this study, ... -
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis
(Journal article, 2021)Background Secretoneurin is a novel prognostic biomarker that may predict mortality in heart failure and the occurrence of ventricular arrhythmias. This study reports the within subject variation (CVI), between subject ... -
Biomarker changes as surrogate endpoints in early-phase trials in heart failure with reduced ejection fraction
(Journal article; Peer reviewed, 2022)Aims No biomarker has achieved widespread acceptance as a surrogate endpoint for early-phase heart failure (HF) trials. We assessed whether changes over time in a panel of plasma biomarkers were associated with subsequent ... -
Biomarker signature and pathophysiological pathways in patients with chronic heart failure and metabolic syndrome
(Journal article; Peer reviewed, 2023)Aim The comorbidities that collectively define metabolic syndrome are common in patients with heart failure. However, the role of metabolic syndrome in the pathophysiology of heart failure is not well understood. We ... -
Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency
(Peer reviewed; Journal article, 2016-06-27)Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM). Deficiency of Cbl, whether ... -
Biomarkers and echocardiographic predictors of myocardial dysfunction in patients with hypertension
(Peer reviewed; Journal article, 2015-03-09)The study aimed to identify early echocardiographic and circulating biomarkers of heart failure (HF) in hypertensive patients with normal resting echocardiography. Echocardiography at rest and during exercise, and selected ... -
Biomarkers for Diabetes Mellitus in advanced Peripheral Arterial Disease. Diagnostic performance and outcome prediction of HbA1c, fasting plasma glucose and the oral glucose tolerance test
(Doctoral thesis, 2019-05-14)Background: At present, the diagnosis of diabetes mellitus (DM) is based on the result from either of three tests; HbA1c, fasting plasma glucose (FPG) or 2-hour post glucose-load value following an oral glucose tolerance ... -
Biomarkers of inflammation and left ventricular remodelling in psoriasis patients treated with infliximab
(Journal article; Peer reviewed, 2022)Objective: Psoriasis is an immune mediated disorder associated with T cell activation and cardiovascular disease (CVD). We explored the association of inflammation with left ventricular (LV) remodelling in psoriasis patients ... -
Biomarkers of one-carbon metabolism and B-vitamin status : Targeted metabolomics in rats and humans exploring the effects of PPARα-activation and dietary composition
(Doctoral thesis, 2019-10-04)BACKGROUND: One-carbon metabolism is an overarching term describing central metabolic pathways involved in the transfer of one-carbon units. These include the methionine-homocysteine and folate cycles, as well as the choline ... -
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
(Journal article; Peer reviewed, 2021)Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) ... -
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
(Peer reviewed; Journal article, 2019-06-03)Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. Here we introduce a statistical tool, ...