Blar i Department of Clinical Science på tittel
Viser treff 2163-2182 av 2313
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Therapeutic and prognostic implications of metabolism in acute myeloid leukemia
(Doctoral thesis, 2020-03-06)Acute myeloid leukemia (AML) is a highly aggressive form of blood cancer, characterized by an interruption in the differentiation process and by rapid proliferation of immature myeloid leukemia cells leading to bone marrow ... -
Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid Leukemia - The possibility to target several kinases through inhibition of the various CDC25 isoforms
(Peer reviewed; Journal article, 2014-11-12)The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C. These three molecules are important regulators of several steps in the cell cycle, including the activation of various cyclin-dependent ... -
Therapeutic use of valproic acid and all-trans retinoic acid in acute myeloid leukemia—literature review and discussion of possible use in relapse after allogeneic stem cell transplantation
(Journal article; Peer reviewed, 2021)Even though allogeneic stem cell transplantation is the most intensive treatment for acute myeloid leukemia (AML), chemo-resistant leukemia relapse is still one of the most common causes of death for these patients, as is ... -
Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis
(Journal article; Peer reviewed, 2021)Adrenal insufficiency (AI) is a life-threatening condition requiring life-long glucocorticoid (GC) substitution therapy, as well as stress adaptation to prevent adrenal crises. The number of individuals with primary and ... -
“This path I must walk alone”. Challenges experienced by older patients while recovering from severe COVID-19 – a qualitative study
(Journal article; Peer reviewed, 2022)Background In March 2020, the COVID-19 pandemic challenged both the Norwegian population and healthcare system. In this study we explored how older men and women experienced rehabilitation and recovery after hospitalisation ... -
Three differently generated salmon protein hydrolysates reveal opposite effects on hepatic lipid metabolism in mice fed a high-fat diet
(Peer reviewed; Journal article, 2015-03-17)This study investigates the effects of salmon peptide fractions, generated using different enzymatic hydrolyzation methods, on hepatic lipid metabolism. Four groups of mice were fed a high-fat diet with 20% casein (control ... -
Thrombectomy in large vessel occlusion stroke—Does age matter?
(Journal article; Peer reviewed, 2022)Objectives Endovascular treatment (EVT) is the gold standard treatment for emergent large vessel occlusion (LVO). The benefit of EVT for emergent LVO in elderly patients (>80 years old) is still debated as they have been ... -
Thrombocytopaenia in the critically ill
(Journal article; Peer reviewed, 2021) -
Thrombosis and thrombocytopenia after HPV vaccination
(Journal article; Peer reviewed, 2021)Background Vaccine-induced immune thrombotic thrombocytopenia (VITT) has so far only been reported after adenovirus vector severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. Objective We report ... -
Thrombus characteristics evaluated by acute optical coherence tomography in ST elevation myocardial Infarction
(Journal article; Peer reviewed, 2022)Aims ST elevation myocardial infarction (STEMI) is caused by an occlusive thrombosis of a coronary artery. We wanted to assess if the thrombus can be characterized according to erythrocyte content and age using intravascular ... -
Tick-borne infections in Sogn og Fjordane, western Norway. Seroprevalence, risk factors and subjective health complaints in blood donors
(Doctoral thesis, 2017-09-15)Background: The tick Ixodes ricinus is involved in the transmission of a large variety of pathogens of medical and veterinary importance in Norway. The most prevalent human tickborne disease in the country is Lyme borreliosis, ... -
Tidal breathing parameters in extremely premature infants. Feasibility and clinical utility of electromagnetic inductance plethysmography
(Doctoral thesis, 2018-09-06)Background: Extremely preterm (EP) birth is associated with adverse lung growth, due to disturbance of programmed and fine-tuned sequences of normal intrauterine development, as well as the trauma inflicted by life-saving ... -
Tidal Expiratory Flow Limitation. A new method for evaluating pulmonary function in elderly and patients with Chronic Obstructive Pulmonary Disease
(Doctoral thesis, 2018-01-18)Background: Lung function declines with old age and is further accelerated by exposure to noxious particles. As our society ages, expected lifespan increases, and prevalence of chronic obstructive pulmonary disease (COPD) ... -
Tidal volumes and pressures delivered by the NeoPuff T-piece resuscitator during resuscitation of term newborns
(Journal article; Peer reviewed, 2022)Aim: T-piece resuscitators are commonly used for respiratory support during newborn resuscitation. This study aimed to describe delivered pressures and tidal volumes when resuscitating term newborns immediately after birth, ... -
Tidal volumes and pressures delivered by the NeoPuff T-piece resuscitator during resuscitation of term newborns
(Journal article; Peer reviewed, 2022)Aim: T-piece resuscitators are commonly used for respiratory support during newborn resuscitation. This study aimed to describe delivered pressures and tidal volumes when resuscitating term newborns immediately after birth, ... -
Tigecycline attenuates polymorphonuclear leukocyte (PMN) receptors but not functions
(Peer reviewed; Journal article, 2011)Tigecycline achieves high intracellular concentrations in polymorphonuclear leukocytes (PMNs). To evaluate the effects of tigecycline on human PMNs, PMNs were incubated with tigecycline dilutions (0.1 to 100 mg L–¹). ... -
Time-Resolved Concentrations of Serum Amino Acids, One-carbon Metabolites, and B-vitamin Biomarkers during the Postprandial and Fasting State: The Postprandial Metabolism in Healthy Young Adults (PoMet) study
(Journal article; Peer reviewed, 2023)Metabolomics has been utilised in epidemiological studies to investigate biomarkers of nutritional status and metabolism in relation to non-communicable diseases. However, little is known about the effect of prandial status ... -
Timing of menarche in Norwegian girls: Associations with body mass index, waist circumference and skinfold thickness
(Peer reviewed; Journal article, 2017-06-06)Background: Research studies show conflicting results regarding the association between menarche and body weight. The purpose of the present study was to investigate if anthropometric indicators of body composition, body ... -
Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer
(Peer reviewed; Journal article, 2016-09-13)Hypoxia is frequent in solid tumors and linked to aggressive phenotypes and therapy resistance. We explored expression patterns of the proposed hypoxia marker HIF-1α in endometrial cancer (EC) and investigate whether ... -
Tissue characterisation by ultrasound strain imaging. Methodological aspects and gastroenterological applications
(Doctoral thesis, 2012-10-11)Real-Time Elastography (RTE) is a new imaging modality that monitors tissue strain during applied stress. The aim of this thesis was to validate if RTE was a reliable modality to reflect pathologically induced differences ...