Blar i Department of Clinical Science på tittel
Viser treff 2203-2222 av 2318
-
Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
(Journal article; Peer reviewed, 2023)Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a ... -
Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing
(Journal article; Peer reviewed, 2021)Autoimmune polyendocrine syndrome type I (APS-1) is a monogenic model disorder of organ-specific autoimmunity caused by mutations in the Autoimmune regulator (AIRE) gene. AIRE facilitates the expression of organ-specific ... -
Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue's extracellular milieu precede immune responses in Sjögren's syndrome
(Peer reviewed; Journal article, 2013-10-31)Introduction: Our understanding of autoimmunity is skewed considerably towards the late stages of overt disease and chronic inflammation. Defining the targeted organ’s role during emergence of autoimmune diseases is, ... -
Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia
(Journal article; Peer reviewed, 2021)Despite the high heritability of schizophrenia (SCZ), details of its pathophysiology and etiology are still unknown. Recent findings suggest that aberrant inflammatory regulation and microRNAs (miRNAs) are involved. Here ... -
Transcriptomic landscape of blood platelets in healthy donors
(Journal article; Peer reviewed, 2021)Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy ... -
Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1
(Journal article; Peer reviewed, 2022-06-02)Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group ... -
Transsulfuration metabolites and the association with incident atrial fibrillation – An observational cohort study among Norwegian patients with stable angina pectoris
(Journal article; Peer reviewed, 2020)Background/aim Plasma total homocysteine (tHcy) is elevated in patients with persistent vs. paroxysmal atrial fibrillation (AF), and has been related to increased risk of new-onset AF. Homocysteine is degraded to cystathionine ... -
Treadmill walking with body weight support
(Doctoral thesis, 2012-04-27)Background: Rehabilitating walking in patients post-stroke with safe, task-specific, intensive training of sufficient duration, can be challenging. Body weight supported treadmill training (BWSTT) has been proposed as an ... -
Treatment completion for latent tuberculosis infection in Norway: a prospective cohort study
(Peer reviewed; Journal article, 2018-11-19)Background: Successful treatment of latent tuberculosis infection (LTBI) is essential to reduce tuberculosis (TB) incidence rates in low-burden countries. This study measures treatment completion and determinants of ... -
Treatment of Exercise-induced Laryngeal Obstruction : Exploring modalities in short and long term
(Doctoral thesis, 2021-05-07)Background: Exercise-induced laryngeal obstruction (EILO) is an umbrella term describing inappropriate and transient closure of laryngeal structures during exercise, causing breathlessness and/or noisy respiration (stridor). ... -
Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients
(Peer reviewed; Journal article, 2012-10-03)Background: The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, ... -
Trends in antimicrobial resistance and empiric antibiotic therapy of bloodstream infections at a general hospital in Mid-Norway: A prospective observational study
(Peer reviewed; Journal article, 2017-02-02)Background: The occurrence of bloodstream infection (BSI) and antimicrobial resistance have been increasing in many countries. We studied trends in antimicrobial resistance and empiric antibiotic therapy at a medium-sized ... -
Trends in maternal use of snus and smoking tobacco in pregnancy. A register study in southern Norway
(Peer reviewed; Journal article, 2019-12-16)Background: The use of tobacco products including Swedish snus (moist snuff) in pregnancy may cause adverse health outcomes. While smoking prevalence has decreased among fertile women in Norway, snus use has increased ... -
Trends in the occurrence of ischaemic heart disease over time in rheumatoid arthritis: 1821 patients from 1972 to 2017
(Journal article; Peer reviewed, 2022)Objective To evaluate trends of acute myocardial infarction (AMI) and ischaemic heart disease (IHD) in rheumatoid arthritis (RA) patients compared with the general population over time. Method We performed a retrospective ... -
Trimethyllysine predicts all-cause and cardiovascular mortality in community-dwelling adults and patients with coronary heart disease
(Journal article; Peer reviewed, 2021)Aims Trimethyllysine (TML) is involved in carnitine synthesis, serves as a precursor of trimethylamine N-oxide (TMAO) and is associated with cardiovascular events in patients with established coronary heart disease (CHD). ... -
Truncating and zinc-finger variants in GLI2 are associated with hypopituitarism
(Journal article; Peer reviewed, 2022)Variants in transcription factor GLI2 have been associated with hypopituitarism and structural brain abnormalities, occasionally including holoprosencephaly (HPE). Substantial phenotypic variability and nonpenetrance have ... -
The Truth behind the Zeros: A New Approach to Principal Component Analysis of the Neuropsychiatric Inventory
(Journal article; Peer reviewed, 2021)Psychiatric syndromes in dementia are often derived from the Neuropsychiatric Inventory (NPI) using principal component analysis (PCA). The validity of this statistical approach can be questioned, since the excessive ... -
Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients
(Journal article; Peer reviewed, 2020)Background Vitamin B-6 status is routinely measured as pyridoxal 5′-phosphate (PLP) in plasma. Low concentrations of PLP are associated with rheumatic, cardiovascular, and neoplastic diseases. We have previously shown ... -
The tuberculin skin test in school going adolescents in South India: associations of socio-demographic and clinical characteristics with TST positivity and non-response
(Peer reviewed; Journal article, 2014-11-18)Background. India has generally used 1 TU purified protein derivative (PPD) as opposed to 2 TU PPD globally, limiting comparisons. It is important to assess latent TB infection in adolescents given that they may be a target ... -
The tuberculin skin test in school going adolescents in South India: associations of socio-demographic and clinical characteristics with TST positivity and non-response
(Peer reviewed; Journal article, 2014-11-18)Background: India has generally used 1 TU purified protein derivative (PPD) as opposed to 2 TU PPD globally, limiting comparisons. It is important to assess latent TB infection in adolescents given that they may be a target ...