Blar i Department of Clinical Science på tittel
Viser treff 477-496 av 2317
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Cryptosporidiosis in low-resource healthcare settings : Near-patient diagnostics, risk factors, and parasite shedding dynamics in young Ethiopian children
(Doctoral thesis, 2023-04-28)Bakgrunn: Tarmparasitten Cryptosporidium er en ledende årsak til diaré og dødsfall hos småbarn i lavinntektsland. Målretta behandling trengs, men forutsetter presise diagnostiske tester som er egna for ressursfattige ... -
Cryptosporidium Infections in Africa—How Important Is Zoonotic Transmission? A Review of the Evidence
(Journal article; Peer reviewed, 2020)Cryptosporidium, a protozoan parasite in the phylum Apicomplexa, is the etiological agent of cryptosporidiosis, an intestinal infection characterized by profuse watery diarrhea. Over 30 species of Cryptosporidium are ... -
CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test
(Journal article; Peer reviewed, 2021)Background Emphysema and exercise induced desaturation (EID) are both related to poorer COPD prognosis. More knowledge of associations between emphysema and desaturation is needed for more efficient disease management. ... -
ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab
(Peer reviewed; Journal article, 2019)Bevacizumab is included in an increasing number of clinical trials. To find biomarkers to predict and monitor treatment response, cancer and angiogenesis relevant mutations in tumour and circulating tumour DNA (ctDNA) were ... -
CTLA-4 as a genetic determinant in autoimmune Addison's disease
(Peer reviewed; Journal article, 2015)In common with several other autoimmune diseases, autoimmune Addison’s disease (AAD) is thought to be caused by a combination of deleterious susceptibility polymorphisms in several genes, together with undefined environmental ... -
Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials
(Journal article; Peer reviewed, 2021)Background Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest ... -
Current transfusion practice and need for new blood products to ensure blood supply for patients with major hemorrhage in Europe
(Journal article; Peer reviewed, 2023)Background: New blood products are considered for treatment of patients with major hemorrhage. The aim of this report is to describe the current transfusion practices in Europe for patients with major hemorrhage and explore ... -
The curse of the uncultured fungus
(Journal article; Peer reviewed, 2022)The international DNA sequence databases abound in fungal sequences not annotated beyond the kingdom level, typically bearing names such as “uncultured fungus”. These sequences beget low-resolution mycological results and ... -
CytoCy5S™, a compound of many structures. in vitro and in vivo evaluation of four near-infrared fluorescent substrates of nitroreductase (NTR)
(Journal article; Peer reviewed, 2021)CytoCy5S™, a quenched, red-shifted fluorescent probe, has been used to exploit the imaging potential of the nitroreductase (NTR) reporter gene platform. Its use has been reported in a number of publications, however there ... -
Cytokine concentrations in plasma from children with severe and non-severe community acquired pneumonia
(Journal article; Peer reviewed, 2015-09-25)Background: Children in low and middle-income countries have a high burden of pneumonia. Measuring the cytokine responses may be useful to identify novel markers for diagnosing, monitoring, and treating pneumonia. Objective: ... -
Cytokine network in adults with falciparum malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity
(Peer reviewed; Journal article, 2014-12-11)Background Co-infection with malaria and HIV increases the severity and mortality of both diseases, but the cytokine responses related to this co-infection are only partially characterised. The aim of this study was to ... -
Cytokine profiles in inflammation
(Doctoral thesis, 2017-06-16)Inflammation is a complex tissue response to harmful stimuli such as microorganisms, damaged or dead cells, or irritants. The inflammatory process can be initiated by many different diseases, including thromboses, neoplastic ... -
Cytokine release syndrome in the immunotherapy of hematological malignancies: The biology behind and possible clinical consequences
(Journal article; Peer reviewed, 2021)Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, ... -
The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells
(Peer reviewed; Journal article, 2015-11)Interactions between acute myeloid leukemia (AML) blasts and neighboring stromal cells are important for disease development and chemosensitivity. However, the molecular mechanisms involved in the cytokine-mediated crosstalk ... -
Cytokines, adhesion molecules, and matrix metalloproteases as predisposing, diagnostic, and prognostic factors in venous thrombosis
(Peer reviewed; Journal article, 2018-05-22)The inflammatory response is a well-established part of, and a prerequisite for, venous thrombosis. To better understand the pathophysiology of venous thrombosis and to identify improved diagnostic biomarkers, further ... -
Daily intake of protein from cod residual material lowers serum concentrations of nonesterified fatty acids in overweight healthy adults: A randomized double-blind pilot study
(Peer reviewed; Journal article, 2018-06-05)Improved process technologies have allowed fishing vessels to utilize residuals from cod fillet production (head, backbone, skin, cuttings, and entrails) and convert this to high-quality protein powders for human consumption. ... -
Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: Clinical results from a randomised phase-2 study (NordCML006)
(Peer reviewed; Journal article, 2014-09-13)We randomised 46 newly diagnosed patients with chronic myeloid leukaemia (median age 56) to receive dasatinib 100 mg QD or imatinib 400 mg QD and report outcome as an intention-to-treat analysis with 36 months follow-up. ... -
Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies
(Journal article; Peer reviewed, 2021-01-20)Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ... -
Deciphering rare imprinting disorders within the Beckwith-Wiedemann spectrum
(Doctoral thesis, 2022-10-28)Beckwith-Wiedemann syndrom (BWS) er den hyppigste og mest komplekse tilstanden blant imprintingssykdommene. Avhandlingen presenterer tre ulike BWS spektrum familier, hvor vi utvider forståelsen av arvemønsteret ved BWS, ... -
Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections
(Journal article; Peer reviewed, 2022)Introduction: Necrotizing Soft Tissue Infections (NSTI) are severe infections with high mortality affecting a heterogeneous patient population. There is a need for a clinical decision support system which predicts outcomes ...