Blar i Department of Clinical Science på tittel
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Diet and effects of diet management on symptoms and quality of life in patients with irritable bowel syndrome
(Master thesis, 2011-05-16)Background: Irritable bowel syndrome (IBS) is a gastrointestinal disorder manifested by abdominal discomfort or pain, bloating and abdominal distension, and changes in the defecation pattern between diarrhoea and constipation. ... -
Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study
(Peer reviewed; Journal article, 2013-10-08)Background: A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence ... -
Dietary linoleic acid induces obesity through excessive endocannabinoid activity
(Doctoral thesis, 2012-03-23)Background: Dietary intakes of the n-6 fatty acid linoleic acid (LA, 18:2n-6) have increased dramatically during the 20th century. Replacing fish oil (FO) with vegetable oil (VO) in feed for farmed fish introduces LA and ... -
Dietary predictors of bone mineral density, hip fractures, mobility and muscle strength - in community-dwelling older persons
(Doctoral thesis, 2018-10-23)Background: The aging process involves decline of both muscle and bone mass. The loss of muscle mass is associated with decreased muscle strength and mobility, while loss of bone mass leads to osteoporosis and increased ... -
Dietary RNA (s. Cerevisiae) stimulated cytokine secretion in human immune cells: involvement of p38 MAPK, and co-stimulation with LPS or PHA
(Master thesis, 2009-07-01)Dietary nucleotides and nucleic acids are known to affect immune functions in animals and humans, both in vitro and in vivo. In this thesis I wanted to investigate the effect of dietary RNA from baker’s yeast on cytokine ... -
Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC)
(Journal article; Peer reviewed, 2022)Background & aims: Visceral adipose tissue (VAT) volume is associated with common lifestyle diseases. Dietary quality, including food matrix and degree of carbohydrate cellularity, as well as the carbohydrate/fat ratio, ... -
Differences in lung function, bronchial hyperresponsiveness and respiratory health between elite athletes competing in different sports
(Journal article; Peer reviewed, 2022)The aim of this study was to examine lung function, bronchial hyperresponsiveness (BHR) and exercise-induced respiratory symptoms in elite athletes performing different sports. Norwegian national-team athletes (30 swimmers, ... -
Differences in metastatic patterns in relation to time between primary surgery and first relapse from breast cancer suggest synchronized growth of dormant micrometastases
(Peer reviewed; Journal article, 2014-08)A significant variation in the metastatic pattern among breast cancer patients exists. Clinical observations suggest that these differences are related to time to recurrence (TTR), thus suggesting a common systemic growth ... -
Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day
(Journal article; Peer reviewed, 2023)Cases with schizophrenia (SCZ) and healthy controls show differences in white blood cell (WBC) counts and blood inflammation markers. Here, we investigate whether time of blood draw and treatment with psychiatric medications ... -
Different adipose tissue development in mice pair fed fish oil and different carbohydrates
(Master thesis, 2011-05-16)Obesity causes several health problems, including insulin resistance, Type 2 diabetes, heart diseases, disrupted energy metabolism and low-grade inflammation. Being obese increases the risk of getting metabolic syndrome. ... -
Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)alpha agonist fenofibrate and the PPAR gamma agonist pioglitazone
(Peer reviewed; Journal article, 2009-03-30)Background: All the peroxisome proliferator activated receptors (PPARs) are found to be expressed in bone cells. The PPARγ agonist rosiglitazone has been shown to decrease bone mass in mice and thiazolidinediones (TZDs) ... -
Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation
(Journal article; Peer reviewed, 2020)Background Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes myeloid cells with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood of ... -
Differential sensitivity of the 2020 revised comprehensive diagnostic criteria and the 2019 ACR/EULAR classification criteria across IgG4-related disease phenotypes: results from a Norwegian cohort
(Journal article; Peer reviewed, 2023)Background We investigated sensitivity of the 2020 Revised Comprehensive Diagnostic Criteria (RCD) and the 2019 ACR/EULAR classification criteria across the four identified IgG4-related disease (IgG4-RD) phenotypes: ... -
Diffusing capacity of the lung for carbon monoxide. Variability and longitudinal changes over nine years
(Doctoral thesis, 2019-03-13)Pulmonary gas exchange oxygenates our blood and facilitates transfer of carbon dioxide produced out of the body. Measurement of pulmonary gas exchange by diffusing capacity of the lung for carbon monoxide (DLCO) shows a ... -
Diffusion tension imaging is a good tool for assessing patients with dementia and behavioral problems and discriminating them from other dementia patients
(Journal article; Peer reviewed, 2021)Background Dementia is one of the leading public health concerns as the world’s population ages. Although Alzheimer’s disease (AD) is the most common dementia diagnosis among older patients, some patients have additional ... -
Diflubenzuron in Atlantic Cod (Gadus morhua) - Multiple Dose Pharmacokinetic Study
(Master thesis, 2012-05-21)Diflubenzuron, a chitin synthesis inhibitor, is used as a parasiticide against sea lice in farmed salmonids. It is administered orally via medicated feed pellets. Due to low bioavailability and biliary secretion of the ... -
Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure
(Journal article; Peer reviewed, 2021)Aims Recently, dipeptidyl peptidase 3 (DPP3) has been discovered as the peptidase responsible for cleavage of angiotensin (1–7) [Ang (1–7)]. Ang (1–7) is part of the angiotensin-converting enzyme–Ang (1–7)–Mas pathway ... -
Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey
(Peer reviewed; Journal article, 2019)Background: The Discharge Care Experiences Survey (DICARES) was previously developed to measure quality of discharge care in elderly patients (≥ 65 years). The objective of this study was to test the factorial validity of ... -
Discovery and characterization of novel STAT3 and androgen receptor inhibitors in prostate cancer cells
(Doctoral thesis, 2020-05-04)Prostate cancer (PCa) recurs and leads to incurable castration-resistant prostate cancer (CRPC) after the failure of androgen deprivation therapies (ADT). CRPC development relies on androgen receptor (AR) signalling. The ... -
Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy
(Peer reviewed; Journal article, 2015)Owing to their integral involvement in cell cycle regulation, the Polo-like kinase (Plk) family, particularly Plk1, has emerged as an attractive therapeutic target in oncology. In recent years, several Plk1 inhibitors have ...