Blar i Department of Clinical Science på tittel

Viser treff 1044-1063 av 2295

    • Identifikasjon av fettsyrer i omega-3 produkter ved hjelp av gasskromatografi med massespektrometrisk deteksjon 

      Wasta, Ziar Miran (Master thesis, 2012-08-24)
      The purpose of this study was to identify fatty acids in omega-3 products that are sold in the market in different countries and build databases of mass spectra and chromatographic retention indices. These databases can ...

    • Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics 

      Lam, Max; Chen, Chia-Yen; Ge, Tian; Xia, Yan; Hill, David W.; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail; Stahl, Eli A.; Huckins, Laura; Liewald, David C.; Djurovic, Srdjan; Melle, Ingrid; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri J.; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widen, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Hartmann, Annette M.; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Koltai, Deborah; Need, AC; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson B.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Hellard, Stephanie Francoise Claire Le; Keller, Matthew C.; Andreassen, Ole; Deary, Ian J.; Glahn, David C.; Huang, Hailiang; Liu, Chunyu; Malhotra, Anil K.; Lencz, Todd (Journal article; Peer reviewed, 2021)
      Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, and these impairments are inadequately addressed by current medications. While novel drug targets for ...

    • Identifying target areas of medicines information efforts to pregnant and breastfeeding women by reviewing questions to SafeMotherMedicine: A Norwegian web-based public medicines information service 

      Bakkebø, Tina; Heitmann, Kristine; Vågsvoll, Kamilla; Erdal, Hilde; Schjøtt, Jan Didrik (Journal article; Peer reviewed, 2022)
      Background Online information about safety of medications during pregnancy and breastfeeding is shown to be conflicting, resulting in anxiety and abstaining from use. The aim of this study was to characterize questions ...

    • Identifying targets for antibiotic stewardship interventions through analysis of the antibiotic prescribing process in hospitals - a multicentre observational cohort study 

      Wathne, Jannicke Slettli; Skodvin, Brita; Charani, Esmita; Harthug, Stig; Blix, Hege Salvesen; Nilsen, Roy Miodini; Kleppe, Lars Kåre Selland; Vukovic, Marta; Smith, Ingrid (Journal article; Peer reviewed, 2020)
      Background: In order to change antibiotic prescribing behaviour, we need to understand the prescribing process. The aim of this study was to identify targets for antibiotic stewardship interventions in hospitals through ...

    • IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia 

      Huuhtanen, Jani; Ilander, Mette; Yadav, Bhagwan; Dufva, Olli M.J.; Lähteenmäki, Hanna; Kasanen, Tiina; Klievink, Jay; Olsson-Strömberg, Ulla; Stentoft, Jesper; Richter, Johan; Koskenvesa, Perttu; Höglund, Martin; Söderlund, Stina; Dreimane, Arta; Porkka, Kimmo; Gedde-Dahl, Tobias; Gjertsen, Bjørn Tore; Stenke, Leif; Myhr-Eriksson, Kristina; Markevärn, Berit; Lübking, Anna; Dimitrijevic, Andreja; Udby, Lene; Bjerrum, Ole Weis; Hjorth-Hansen, Henrik; Mustjoki, Satu (Journal article; Peer reviewed, 2022)
      In chronic myeloid leukemia (CML), combination therapies with tyrosine kinase inhibitors (TKIs) aim to improve the achievement of deep molecular remission that would allow therapy discontinuation. IFN-α is one promising ...

    • Ikke stikk fingrene i stikkontakten 

      Brudvik, Christina Elisabeth (Journal article, 2022)

    • IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria 

      Otterdal, Kari; Berg, Åse; Michelsen, Annika Elisabet; Yndestad, Arne; Patel, Sam; Gregersen, Ida; Halvorsen, Bente; Ueland, Thor; Langeland, Nina; Aukrust, Pål (Journal article; Peer reviewed, 2021)
      Background: Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes. In clinical falciparum malaria, with and without ...

    • IL-6 Responsiveness of CD4+ and CD8+ T Cells after Allogeneic Stem Cell Transplantation Differs between Patients and Is Associated with Previous Acute Graft versus Host Disease and Pretransplant Antithymocyte Globulin Therapy 

      Tvedt, Tor Henrik Anderson; Rose-John, Stefan; Tsykunova, Galina; Ahmed, Aymen B; Gedde-Dahl, Tobias; Ersvær, Elisabeth; Bruserud, Øystein (Journal article; Peer reviewed, 2022)
      Graft-versus-host disease (GVHD), one of the most common and serious complications after allogeneic stem cell transplantation, is mediated by allocative T cells. IL-6 mediates both pro- and anti-inflammatory effects and ...

    • ILD-­specific health-­related quality of life in systemic sclerosis-­associated ILD compared with IPF 

      Durheim, Michael; Hoffmann-Vold, Anna-Maria; Eagan, Tomas Mikal; Hovden, Arnt-Ove; Samersaw-Lund, May Brit; Bjerke, Gisle; Birring, Surinder S.; Jonassen, Trygve Müller; Johansen, Odd Erik; Sjåheim, Tone Bjørg (Journal article; Peer reviewed, 2020)
      Abstract Introduction Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) are fibrotic ILDs with divergent disease populations. Little is known about health-related ...

    • Illicit substances detected through high-resolution MS analysis in urine samples are associated with greater symptom burden in patients with psychosis 

      Skrede, Silje; Berg, Jon Andsnes; Fossan, Kjell Ove; Bartz-Johannessen, Christoffer; Løberg, Else-Marie; Kroken, Rune Andreas; Johnsen, Erik (Journal article, 2021)
      Background The prevalence of new psychoactive substances (NPS) in acute psychotic patients has not been investigated systematically. We applied a highly sensitive and specific mass spectrometry method for detection of NPS ...

    • Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe 

      Malicki, Stanisław; Pucelik, Barbara; Żyła, Edyta; Benedyk-Machaczka, Małgorzata; Gałan, Wojciech; Golda, Anna; Sochaj-Gregorczyk, Alicja; Kaminska, Marta; Encarnação, João Crispim; Chruścicka, Barbara; Marti, Hans Peter; Chen, Tony Jialiang; Magiera-Mularz, Katarzyna; Zięba, Bartosz; Holak, Tad A.; Dabrowski, Janusz M.; Czarna, Anna; Kozieł, Joanna; Mydel, Piotr Mateusz; Dubin, Grzegorz (Journal article; Peer reviewed, 2022-06-01)
      Immune checkpoint targeting immunotherapy has revolutionized the treatment of certain cancers in the recent years. Determination of the status of immune checkpoint expression in particular cancers may assist decision making. ...

    • Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial 

      Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil; Kvale, Dag (Peer reviewed; Journal article, 2017-05-02)
      Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. ...

    • Immune cells and soluble immune markers in different stages of tuberculosis. Potential biomarkers for diagnosis and treatment efficacy 

      Wergeland, Ida (Doctoral thesis, 2017-03-30)
      Tuberculosis (TB) is a major global health problem, especially in the developing world. In order to end the TB epidemic, reliable and rapid diagnostic tools that can identify and discriminate between latent and active TB ...

    • Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis 

      Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica Bettina E. Greenwood; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)
      Several lines of evidence implicate immune abnormalities in the pathophysiology of severe mental disorders (SMD) and comorbid mental disorders. Here, we use the data from genome-wide association studies (GWAS) of autoimmune ...

    • Immune regulatory mechanisms in endocrine autoimmune disorders 

      Sjøgren, Thea (Doctoral thesis, 2023-09-15)
      Ulike mekanismer eksisterer for at immunforsvaret skal lære å skille det som er eget fra det som er fremmed, også kjent som immunologisk toleranse. I noen tilfeller brytes denne toleransen, noe som kan føre til at enkelte ...

    • Immune response to influenza after vaccination and infection 

      Mohn, Kristin Greve-Isdahl (Doctoral thesis, 2016-09-23)
      Influenza causes great human morbidity and mortality from annual epidemics and pandemics occurring at irregular intervals. The socioeconomic impact of influenza is significant with 5% of adults and 20% of children infected, ...

    • Immune Responses in Acute and Convalescent Patients with Mild, Moderate and Severe Disease during the 2009 Influenza Pandemic in Norway 

      Mohn, Kristin Greve-Isdahl; Cox, Rebecca Jane; Tunheim, Gro; Berdal, Jan Erik; Hauge, Anna G; Jul-Larsen, Åsne; Peters, Bjørn; Oftung, Fredrik; Jonassen, Christine M; Mjaaland, Siri (Peer reviewed; Journal article, 2015-11-25)
      Increased understanding of immune responses influencing clinical severity during pandemic influenza infection is important for improved treatment and vaccine development. In this study we recruited 46 adult patients during ...

    • The immunogenicity of intranasal adjuvanted pandemic avian influenza vaccine in murine model 

      Pham, Nam Cong (Master thesis, 2009-07-02)
      Influenza vaccination remains the primary method for the prevention of influenza and the severe complications related to the disease. Development of an intranasal vaccination strategy will not only prevent the disease but ...

    • Immunoglobulin-storing histiocytosis: A case based systemic review 

      Wiese-Hansen, Hanne; Leh, Friedemann; Hemsing, Anette Lodvir; Reikvam, Håkon (Journal article; Peer reviewed, 2021)
      Crystal-storing histiocytosis (CSH) is a rare event in disorders associated with monoclonal gammopathy and is mostly associated with the accumulation of immunoglobulins (Igs) in the cytoplasm of histiocytes. In this article, ...

    • Immunohistochemical biomarkers are prognostic relevant in addition to the ESMO-ESGO-ESTRO risk classification in endometrial cancer 

      Vrede, S.W.; van Weelden, Willem Jan; Visser, Nicole C.M.; Bulten, Johan; Van Der Putten, Louis J.M.; Van De Vijver, Koen; Santacana, Maria; Colas, Eva; Gil-Moreno, Antonio; Moiola, Cristian P.; Mancebo, Gemma; Krakstad, C.; Trovik, J.; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Bednarikova, M.; Hausnerova, Jitka; van der Wurff, der; Matias-Guiu, Xavier; Amant, Frédéric; Snijders, Marc P.L.M.; Küsters-Vandevelde, Heidi V.N.; Reijnen, Casper; Pijnenborg, Johanna M.A. (Journal article; Peer reviewed, 2021)
      Objective: Pre-operative immunohistochemical (IHC) biomarkers are not incorporated in endometrial cancer (EC) risk classification. We aim to investigate the added prognostic relevance of IHC biomarkers to the ESMO-ESGO-ESTRO ...