Blar i Department of Clinical Science på tittel
Viser treff 1380-1399 av 2310
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MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer
(Peer reviewed; Journal article, 2016-09-14)Two functional SNPs (SNP285G > C; rs117039649 and SNP309T > G; rs2279744) have previously been reported to modulate Sp1 transcription factor binding to the promoter of the proto-oncogene MDM2, and to influence cancer risk. ... -
MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung- and prostate cancer risk.
(Peer reviewed; Journal article, 2015-10-16)The MDM4 protein plays an important part in the negative regulation of the tumor suppressor p53 through its interaction with MDM2. In line with this, MDM4 amplification has been observed in several tumor forms. A polymorphism ... -
Meal patterns associated with energy intake in people with obesity
(Journal article; Peer reviewed, 2022)It is widely assumed that people with obesity have several common eating patterns, including breakfast-skipping (1), eating during the night (2) and high fast-food consumption (3). However, differences in individual meal ... -
Measurement of left ventricular deformation using 3D echocardiography
(Doctoral thesis, 2023-06-05)Bakgrunn: 3D speckle tracking ekkokardiografi (STE) er en hjerteultralydmetode som gir mulighet for måling av deformasjonsparametere, som strain, rotasjon, tvist og torsjon. Den største begrensningen for 3D STE er lav tids- ... -
Measures of symmetry in gait. Methodological principles and clinical choices
(Doctoral thesis, 2012-02-24)The aim of this thesis is to evaluate measures of gait symmetry in subjects with disease or injury related to one-sided affection. This thesis also aims to relate objective measures of gait quality (gait symmetry) to other ... -
Measuring discharge care quality in hospitalised elderly: Development and validation of an instrument based on patients’ experiences
(Doctoral thesis, 2020-03-20)Background: Elderly patients account for a majority of hospital admissions. Their wellbeing and safety are at risk in the discharge process due to quality deficiencies, thus, accurate and vigorous instruments to monitor ... -
Measuring discharge quality based on elderly patients’ experiences with discharge conversation: a cross-sectional study
(Peer reviewed; Journal article, 2019)Background: Discharge conversation is an essential part of preparing patients for the period after hospitalisation. Successful communication during such conversations is associated with improved health outcomes for patients. ... -
Mechanical assist in cardiac arrest: Optimising circulatory support. Experimental studies.
(Doctoral thesis, 2022-03-30)Introduction: Mechanical circulatory support (MCS) may be useful in cardiac arrest (CA), both in- and out- of hospital. However, efficacy and survival benefit has been difficult to evaluate compared to standard cardiopulmonary ... -
Mechanical behavior and collagen structure of degenerative mitral valve leaflets and a finite element model of primary mitral regurgitation
(Journal article; Peer reviewed, 2023)Degenerative mitral valve disease is the main cause of primary mitral regurgitation with two phenotypes: fibroelastic deficiency (FED) often with localized myxomatous degeneration and diffuse myxomatous degeneration or ... -
Medikamentbruk blant ungdommer i Sogn og Fjordane. En samling av tversnittstudier fra 97-09
(Master thesis, 2013-05-21)Ungdomstiden er en periode i livet preget av mye usikkerhet og tilpasning i forhold til endringene som puberteten medfører. Denne overgangsfasen fra barn til voksen gjør i seg selv ungdommer sårbare, og dersom de i tillegg ... -
Menopause as a predictor of new-onset asthma
(Peer reviewed; Journal article, 2015-01)Background: There is limited and conflicting evidence on the effect of menopause on asthma. Objectives: We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal ... -
Mesenchymal stem cells support survival and proliferation of primary human acute myeloid leukemia cells through heterogeneous molecular mechanisms
(Peer reviewed; Journal article, 2017-02-09)Acute myeloid leukemia (AML) is a bone marrow malignancy, and various bone marrow stromal cells seem to support leukemogenesis, including osteoblasts and endothelial cells. We have investigated how normal bone marrow ... -
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1
(Peer reviewed; Journal article, 2015-12-01)High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using ... -
Metabolic and Epigenetic Regulation by Estrogen in Adipocytes
(Journal article; Peer reviewed, 2022-02-22)Sex hormones contribute to differences between males and females in body fat distribution and associated disease risk. Higher concentrations of estrogens are associated with a more gynoid body shape and with more fat storage ... -
Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders
(Peer reviewed; Journal article, 2020)Background: We aimed at exploring potential pathophysiological processes across psychotic disorders, applying metabolomics in a large and well-characterized sample of patients and healthy controls. Methods: Patients with ... -
Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics
(Peer reviewed; Journal article, 2015-12)Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, but ... -
Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers
(Peer reviewed; Journal article, 2012-07-30)It is important to identify patients with Maturity-onset diabetes of the young (MODY) as a molecular diagnosis determines both treatment and prognosis. Genetic testing is currently expensive and many patients are therefore ... -
Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease
(Journal article; Peer reviewed, 2023)Background: The valine (branched-chain amino acid) metabolite 3-hydroxyisobutyrate (3-HIB), produced by 3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH), is associated with insulin resistance and type 2 diabetes, but implicated ... -
Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome
(Peer reviewed; Journal article, 2015-12)Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant ... -
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
(Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ...