Browsing Department of Clinical Science by Title
Now showing items 1475-1494 of 2295
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A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001–15: introduction and spread of ESBLs facilitated by clonal groups CG15 and CG307
(Journal article; Peer reviewed, 2022)Objectives To use the nationwide Norwegian surveillance programme on resistant microbes in humans (NORM) to address longitudinal changes in the population structure of Klebsiella pneumoniae isolates from 2001–15, focusing ... -
A nationwide school fruit and vegetable policy and childhood and adolescent overweight: A quasi-natural experimental study
(Journal article; Peer reviewed, 2022)Background School free fruit and vegetable (FFV) policies are used to promote healthy dietary habits and tackle obesity; however, our understanding of their effects on weight outcomes is limited. We assess the effect of ... -
The natural history of 21-hydroxylase autoantibodies in autoimmune Addison’s disease
(Journal article; Peer reviewed, 2021)Background: The most common cause of primary adrenal failure (Addison’s disease) in the Western world is autoimmunity characterized by autoantibodies against the steroidogenic enzyme 21-hydroxylase (CYP21A2, 21OH). Detection ... -
Nausea and vomiting of pregnancy and hyperemesis gravidarum
(Peer reviewed; Journal article, 2019)Nausea and vomiting of pregnancy (NVP) is a common condition that affects as many as 70% of pregnant women. Although no consensus definition is available for hyperemesis gravidarum (HG), it is typically viewed as the severe ... -
Nausea Predicts Bacteremia in Immunocompetent Patients with Pneumococcal Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort
(Journal article; Peer reviewed, 2023)Background: In pneumococcal community-acquired pneumonia (CAP), bacteremia is associated with increased mortality, but initial clinical severity scores frequently fail to identify bacteremic patients at risk. We have ... -
Near-Infrared Fluorescent Imaging for Monitoring of Treatment Response in Endometrial Carcinoma Patient-Derived Xenograft Models.
(Journal article; Peer reviewed, 2020)Imaging of clinically relevant preclinical animal models is critical to the development of personalized therapeutic strategies for endometrial carcinoma. Although orthotopic patient-derived xenografts (PDXs) reflecting ... -
Need of education for dry powder inhaler storage and retention – a patient-reported survey
(Peer reviewed; Journal article, 2016-06-08)Background Dry powder inhalers (DPIs) are the most commonly used devices in asthma treatment in the Nordic countries. As new DPIs become available, patients are likely to be exposed to more than one type of device, with ... -
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
(Journal article; Peer reviewed, 2016)Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial ... -
Neonatal outcomes associated with time from a high fetal blood lactate concentration to operative delivery
(Journal article; Peer reviewed, 2023)Introduction: Adjunctive technologies to cardiotocography intend to increase the specificity of the diagnosis of fetal hypoxia. If correctly diagnosed, time to delivery could affect neonatal outcome. In the present study, ... -
Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren’s syndrome
(Journal article; Peer reviewed, 2020)Background To test the hypothesis that neurofilament light (NfL) in CSF is a biomarker of CNS involvement in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS), we measured NfL in CSF ... -
Neuroinflammation Associated With Inborn Errors of Immunity
(Journal article; Peer reviewed, 2022)The advent of high-throughput sequencing has facilitated genotype-phenotype correlations in congenital diseases. This has provided molecular diagnosis and benefited patient management but has also revealed substantial ... -
Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes
(Journal article; Peer reviewed, 2022-05-05)Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are ... -
Neuropsychiatric symptoms in dementia: long-term course and neuropathology
(Doctoral thesis, 2019-06-14)Aim: Neuropsychiatric symptoms (NPS) such as anxiety, apathy, and psychosis are important manifestations of dementia that have a major impact on the patient’s quality of life, carer burden, and risk of institutionalisation. ... -
The neutral amino acid transporter SLC7A10 in adipose tissue, obesity and insulin resistance
(Journal article; Peer reviewed, 2022)Obesity, insulin resistance and type 2 diabetes represent major global health challenges, and a better mechanistic understanding of the altered metabolism in these conditions may give improved treatment strategies. SLC7A10, ... -
The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab
(Peer reviewed; Journal article, 2014-10-04)Background: The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ... -
The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab
(Peer reviewed; Journal article, 2014-10-04)Background. The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ... -
Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes
(Journal article; Peer reviewed, 2023)Background Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information ... -
Neutrophil-to-lymphocyte ratio and outcomes in patients with new-onset or worsening heart failure with reduced and preserved ejection fraction
(Journal article; Peer reviewed, 2021)Aims Inflammation is thought to play a role in heart failure (HF) pathophysiology. Neutrophil-to-lymphocyte ratio (NLR) is a simple, routinely available measure of inflammation. Its relationship with other inflammatory ... -
New biomarkers in patients with chronic kidney disease, after kidney transplantation, in kidney donors and in acute myocardial infarction
(Doctoral thesis, 2024-01-12)Nye markører på nyreskade hos nyretransplanterte, nyre donorer, hos pasienter med nyresvikt og hos pasienter med akutt hjerteinfarkt Bakgrunn: Kronisk nyresvikt affiserer mange mennesker. Både insidens og prevalens ... -
New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation
(Journal article; Peer reviewed, 2020)Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of ...