Blar i Department of Clinical Science på tittel
Viser treff 1590-1609 av 2295
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Pathophysiological pathways in patients with heart failure and atrial fibrillation
(Journal article; Peer reviewed, 2022)Aims Atrial fibrillation (AF) and heart failure (HF) are two growing epidemics that frequently co-exist. We aimed to gain insights into the underlying pathophysiological pathways in HF patients with AF by comparing ... -
Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure
(Journal article; Peer reviewed, 2022)Aims Elevated concentrations of growth differentiation factor 15 (GDF-15) in patients with heart failure (HF) have been consistently associated with worse clinical outcomes, but what disease mechanisms high GDF-15 ... -
PathwayMatcher: proteoform-centric network construction enables fine-granularity multi-omics pathway mapping
(Peer reviewed; Journal article, 2019-07-30)Background Mapping biomedical data to functional knowledge is an essential task in bioinformatics and can be achieved by querying identifiers (e.g., gene sets) in pathway knowledge bases. However, the isoform and ... -
Pathway‑level mutation analysis in primary high‑grade serous ovarian cancer and matched brain metastases
(Journal article; Peer reviewed, 2022)Brain metastases (BMs) in ovarian cancer (OC) are a rare event. BMs occur most frequently in high-grade serous (HGS) OC. The molecular features of BMs in HGSOC are poorly understood. We performed a whole-exome sequencing ... -
Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells
(Journal article; Peer reviewed, 2021)Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy, and non-leukemic stromal cells (including mesenchymal stem cells, MSCs) are involved in leukemogenesis and show AML-supporting effects. We investigated ... -
Patient safety in surgical environments: Cross-countries comparison of psychometric properties and results of the Norwegian version of the Hospital Survey on Patient Safety
(Peer reviewed; Journal article, 2010-09-22)Background: How hospital health care personnel perceive safety climate has been assessed in several countries by using the Hospital Survey on Patient Safety (HSOPS). Few studies have examined safety climate factors in ... -
Patient-derived organoids reflect the genetic profile of endometrial tumors and predict patient prognosis
(Journal article; Peer reviewed, 2021)Background: A major hurdle in translational endometrial cancer (EC) research is the lack of robust preclinical models that capture both inter- and intra-tumor heterogeneity. This has hampered the development of new treatment ... -
Patient-reported outcomes and associations with pleural effusion in outpatients with heart failure: an observational cohort study
(Peer reviewed; Journal article, 2017)Objectives: We aimed to study whether patient-reported outcomes, measured by quality of life (QoL) and functional class, are sensitive to pleural effusion (PLE) in patients with heart failure (HF), and to study changes in ... -
Patients with Bacterial Sepsis Are Heterogeneous with Regard to Their Systemic Lipidomic Profiles
(Journal article; Peer reviewed, 2023)Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In the present study, we investigated the systemic/serum lipidomic profile at the time of hospital admission for ... -
Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes
(Journal article; Peer reviewed, 2023)Schizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic susceptibility, and immune alterations. We aimed to identify differential transcriptional patterns in peripheral blood cells of patients ... -
Patients with treatment-requiring chronic graft versus host disease after allogeneic stem cell transplantation have altered metabolic profiles due to the disease and immunosuppressive therapy: Potential implication for biomarkers
(Journal article; Peer reviewed, 2018)Chronic graft versus host disease (cGVHD) is a common long-term complication after allogeneic hematopoietic stem cell transplantation. The objective of our study was to compare the metabolic profiles for allotransplant ... -
Patients' knowledge and attitudes regarding living with implantable electronic devices: Results of a multicentre, multinational patient survey conducted by the European Heart Rhythm Association
(Peer reviewed; Journal article, 2018-02)The purpose of this patient survey was to analyse the knowledge, experiences, and attitudes regarding cardiac implantable electronic devices (CIED) in patients with pacemakers, implantable cardioverter-defibrillators (ICDs), ... -
Patterns of genomic evolution in advanced melanoma
(Peer reviewed; Journal article, 2018-07-10)Genomic alterations occurring during melanoma progression and the resulting genomic heterogeneity between metastatic deposits remain incompletely understood. Analyzing 86 metastatic melanoma deposits from 53 patients with ... -
Påvirkning av stabilisator i phytantriol-baserte kubosomer og dens potensielle anvendelse som intravenøs levering av lumefantrin
(Master thesis, 2023-06-05)Malaria er en parasittsykdom som tar livet av nesten av en halv million mennesker hvert år. Malariabyrden har gått betraktelig ned på verdensbasis, men for 84 land gjenstår det å utrydde sykdommen. Lumefantrin (LUM) i ... -
Påvising av aminoglykosidresistens ved hjelp av massespektrometri. Utvikling av metode for deteksjon, stabilitet av aminoglykosid og molekylær karakterisering av teststammer
(Master thesis, 2014-05-20)Aminoglykosid er potente antibiotika som vert brukt til behandling av alvorlege infeksjonar med aerobe bakteriar. Dei er baktericide og verkar ved å binda til ribosoma i bakteriane og på denne måten forstyrra den normale ... -
PCR based Malaria diagnostics : – Method development and application
(Doctoral thesis, 2019-11-12)Background Almost half of the world’s population is at risk of malaria. Malaria is a parasitic vector borne disease spread by infected female Anopheles mosquitos. The protozoan parasite belongs to the genus Plasmodium ... -
PCR targeting Plasmodium mitochondrial genome of DNA extracted from dried blood on filter paper compared to whole blood
(Peer reviewed; Journal article, 2014-04-07)Background: Monitoring mortality and morbidity attributable to malaria is paramount to achieve elimination of malaria. Diagnosis of malaria is challenging and PCR is a reliable method for identifying malaria with high ... -
Peak oxygen uptake and breathing pattern in COPD patients – a four-year longitudinal study
(Peer reviewed; Journal article, 2015-08-19)Background: Activities of daily living in patients with chronic obstructive pulmonary disease (COPD) are limited by exertional dyspnea and reduced exercise capacity. The aims of the study were to examine longitudinal changes ... -
Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size
(Journal article; Peer reviewed, 2020)Background: The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic ... -
Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: A multicenter cohort study
(Peer reviewed; Journal article, 2019)Peptide receptor radionuclide therapy (PRRT) is an established treatment of metastatic neuroendocrine tumors grade 1–2 (G1–G2). However, its possible benefit in high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms ...