Blar i Department of Clinical Science på tittel
Viser treff 1862-1881 av 2310
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Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth
(Peer reviewed; Journal article, 2016-05-10)The estrogen receptor alpha (ERα) is highly expressed in both endometrial and breast cancers, and represents the most prevalent therapeutic target in breast cancer. However, anti-estrogen therapy has not been shown to be ... -
Reduced delays in diagnostic pathways for non-small cell lung cancer after local and National initiatives
(Journal article; Peer reviewed, 2020)Objectives Patients with non-small cell lung cancer (NSCLC) may experience progression and stage shift due to delays in a complex and time-consuming diagnostic work-up. We have analyzed the impact of both a local and ... -
Reduced Endothelial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome–Results From Open-Label Cyclophosphamide Intervention Study
(Journal article; Peer reviewed, 2021)Introduction: Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) present with a range of symptoms including post-exertional malaise (PEM), orthostatic intolerance, and autonomic dysfunction. Dysfunction ... -
Reduced expression of innate immunity-related genes in lymph node metastases of luminal breast cancer patients
(Journal article; Peer reviewed, 2021)Immune system plays a dual role in cancer by either targeting or supporting neoplastic cells at various stages of disease, including metastasis. Yet, the exact immune-related transcriptome profiles of primary tumours (PT) ... -
Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes: the PROLONG study
(Journal article; Peer reviewed, 2021)Type 1 diabetes is a chronic autoimmune disease requiring insulin treatment for survival. Prolonged duration of type 1 diabetes is associated with increased risk of microvascular complications. Although chronic hyperglycemia ... -
Reduced lung function and cause-specific mortality: A population-based study of Norwegian men followed for 26 years
(Journal article; Peer reviewed, 2023)Background and aim Reduced lung function is associated with increased mortality, but it is unclear how different spirometric patterns are related to specific deaths. Aim of this study was to investigate these associations ... -
Reduced Plasma Guanylin Levels Following Enterotoxigenic Escherichia coli-Induced Diarrhea
(Journal article; Peer reviewed, 2023)The intestinal peptide hormones guanylin (GN) and uroguanylin (UGN) interact with the epithelial cell receptor guanylate cyclase C to regulate fluid homeostasis. Some enterotoxigenic Escherichia coli (ETEC) produce heat-stable ... -
Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia
(Peer reviewed; Journal article, 2015-03-13)Background: Hemodynamic control was compared in patients with mild cognitive impairment (MCI) or mild Alzheimer's dementia (AD) as well as in healthy elderly subjects. Methods: Noninvasive, continuous hemodynamic recordings ... -
Reference curves for pediatric endocrinology: leveraging biomarker z-scores for clinical classifications
(Journal article; Peer reviewed, 2022)Context Hormone reference intervals in pediatric endocrinology are traditionally partitioned by age and lack the framework for benchmarking individual blood test results as normalized z-scores and plotting sequential ... -
Reference data for testicular volume measured with ultrasound and pubic hair in Norwegian boys are comparable with Northern European populations
(Peer reviewed; Journal article, 2020)Aim: To estimate references for testicular volume measured with ultrasound and Tanner stages of pubic hair in Norwegian boys, and to compare the timing of puberty with data from similar populations. Methods: Testicular ... -
Reference ranges for head circumference in ethiopian children 0-2 years of age
(Peer reviewed; Journal article, 2015-12)BACKGROUND: Head circumference (HC) charts are important for early detection of hydrocephalus during childhood. In low-income countries where populationbased HC charts are rarely available, hydrocephalus occurs more commonly ... -
Reference ranges of fetal superior vena cava blood flow velocities and pulsatility index in the second half of pregnancy: a longitudinal study
(Journal article; Peer reviewed, 2021)Background Fetal superior vena cava (SVC) is essentially the single vessel returning blood from the upper body to the heart. With approximately 80-85% of SVC blood flow representing cerebral venous return, its interrogation ... -
References for ultrasound staging of breast maturation, tanner breast staging, pubic hair, and menarche in Norwegian girls
(Journal article; Peer reviewed, 2020)Context: Discriminating adipose and glandular tissue is challenging when clinically assessing breast development. Ultrasound facilitates staging of pubertal breast maturation (US B), but has not been systematically compared ... -
Regionale forskjeller i bruk av protonpumpehemmere hos barn
(Journal article; Peer reviewed, 2023)Bakgrunn: Fysiologisk gastroøsofageal refluks i spedbarnsalder er vanskelig å skille fra reflukssykdom. Internasjonale retningslinjer anbefaler restriktiv bruk av syrehemmende behandling til spedbarn på grunn av mangel på ... -
Regular consumption of cod liver oil is associated with reduced basal and exercise-induced C-reactive protein levels; a prospective observational trial: A NEEDED (The North Sea Race Endurance Exercise Study) 2014 sub-study
(Journal article; Peer reviewed, 2021)Background Dietary supplement use among recreational athletes is common, with the intention of reducing inflammation and improving recovery. We aimed to describe the relationship between omega-3 fatty acid supplement use ... -
Regulation of adipogenesis and fat storage by IRX3 and IRX5
(Doctoral thesis, 2020-04-24)Obesity is a highly prevalent disease underlying several chronic diseases including Type 2 diabetes (T2D) and cardiovascular diseases (CVDs). Thus, increasing levels of obesity is associated with a series of co-morbidities ... -
A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density
(Journal article; Peer reviewed, 2021)Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied Genome-wide association studies (GWASs) ... -
Rekonvalesensplasma mot covid-19 fremstilt fra norske blodgivere
(Journal article; Peer reviewed, 2023)BAKGRUNN Ved pandemiens start tok Helsedirektoratet og norske blodbanker initiativ til produksjon av covid-19-rekonvalesensplasma innenfor rammen av kliniske studier. Her beskriver vi blodgiverne som deltok. MATERIALE ... -
Relation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison’s disease
(Journal article; Peer reviewed, 2023)Objective Autoantibodies against the adrenal enzyme 21-hydroxylase is a hallmark manifestation in autoimmune Addison's disease (AAD). Steroid 21-hydroxylase is encoded by CYP21A2, which is located in the human leucocyte ... -
The relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection
(Journal article; Peer reviewed, 2020)Background and objectives The hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations ...