Blar i Department of Clinical Science på tittel
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Tamoxifen in the treatment of luminal breast cancer. Implications of active metabolites on gene expression, side effects and clinical outcome
(Doctoral thesis, 2019-02-21)Estrogen is a driver for the development and progression of luminal breast cancer, and up to 80% of all breast cancers diagnosed belong to the luminal subtype. The estrogenic effect on breast tumors can be reduced by the ... -
Teaching geriatric medicine through gamification: a tool for enhancing postgraduate education in geriatric medicine
(Journal article; Peer reviewed, 2022)Background Polypharmacy is becoming increasingly common and all doctors must be prepared to manage it competently. Aims The aim of this project is to evaluate the feasibility and use of a novel gamification-based ... -
Temporal trends of β-haemolytic streptococcal osteoarticular infections in western Norway
(Peer reviewed; Journal article, 2016-10-04)Background: Beta-haemolytic streptococci are important contributors to the global burden of osteoarticular infections (OAI). Knowledge on the disease traits specific for streptococcal OAI, however, remains scarce. We wished ... -
Tentative longterm effects of a noradrenergic antidepressant; affecting the number of glucose transporters
(Master thesis, 2008-06-01)Major depressive disorder is an affective disorder affecting millions of people worldwide. Only in Europe at least 21 million are thought to be affected. Several theories have been developed during the years trying to ... -
Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty
(Peer reviewed; Journal article, 2020)Context: Testicular growth represents the best clinical variable to evaluate male puberty, but current pediatric hormone references are based on chronological age and subjective assessments of discrete puberty development ... -
Tetradecylthioacetic Acid Increases Hepatic Mitochondrial b-Oxidation and Alters Fatty Acid Composition in a Mouse Model of Chronic Inflammation
(Peer reviewed; Journal article, 2011-04-09)The administration of tetradecylthioacetic acid (TTA), a hypolipidemic and anti-inflammatory modified bioactive fatty acid, has in several experiments based on high fat diets been shown to improve lipid transport and ... -
Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells - gene expression profiling implies endoplasmic reticulum stress
(Peer reviewed; Journal article, 2011-10-25)Background: Previous reports have shown an antiproliferative effect of the synthetic, 3-thia fatty acid tetradecylthioacetic acid (TTA) on different cancer cells in vitro and in vivo. The mechanisms behind the observed ... -
Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice
(Peer reviewed; Journal article, 2016-02-05)Background: Hepatic mitochondrial dysfunction plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Methyl donor supplementation has been shown to alleviate NAFLD, connecting the condition ... -
Thawing plateau time indicating the duration of phase transition from ice to water is the strongest predictor for long-term durable pulmonary vein isolation after cryoballoon ablation for atrial fibrillation—Data from the index and repeat procedures
(Journal article; Peer reviewed, 2023)Introduction: This study aimed to clarify the relationship between the durability of pulmonary vein (PV) isolation and the time of phase transition from ice to water indicated by thawing plateau time in a cryoballoon ... -
The effect of phytosubstances and plant-derived synthetic analogs on acute myeloid leukemia cells
(Master thesis, 2021-05-20) -
The regulation of tyrosine hydroxylase by dopamine and selected binding partners
(Master thesis, 2022-05-20)Tyrosine hydroxylase (TH) catalyses the rate limiting step in the metabolic pathway of dopamine (DA) synthesis and is therefore important in physiological functions such as motor control, cognitive function, and the brain ... -
A theory-informed systematic review of barriers and enablers to implementing multi-drug pharmacogenomic testing
(Journal article; Peer reviewed, 2022)PGx testing requires a complex set of activities undertaken by practitioners and patients, resulting in varying implementation success. This systematic review aimed (PROSPERO: CRD42019150940) to identify barriers and ... -
Therapeutic and prognostic implications of metabolism in acute myeloid leukemia
(Doctoral thesis, 2020-03-06)Acute myeloid leukemia (AML) is a highly aggressive form of blood cancer, characterized by an interruption in the differentiation process and by rapid proliferation of immature myeloid leukemia cells leading to bone marrow ... -
Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid Leukemia - The possibility to target several kinases through inhibition of the various CDC25 isoforms
(Peer reviewed; Journal article, 2014-11-12)The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C. These three molecules are important regulators of several steps in the cell cycle, including the activation of various cyclin-dependent ... -
Therapeutic use of valproic acid and all-trans retinoic acid in acute myeloid leukemia—literature review and discussion of possible use in relapse after allogeneic stem cell transplantation
(Journal article; Peer reviewed, 2021)Even though allogeneic stem cell transplantation is the most intensive treatment for acute myeloid leukemia (AML), chemo-resistant leukemia relapse is still one of the most common causes of death for these patients, as is ... -
Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis
(Journal article; Peer reviewed, 2021)Adrenal insufficiency (AI) is a life-threatening condition requiring life-long glucocorticoid (GC) substitution therapy, as well as stress adaptation to prevent adrenal crises. The number of individuals with primary and ... -
“This path I must walk alone”. Challenges experienced by older patients while recovering from severe COVID-19 – a qualitative study
(Journal article; Peer reviewed, 2022)Background In March 2020, the COVID-19 pandemic challenged both the Norwegian population and healthcare system. In this study we explored how older men and women experienced rehabilitation and recovery after hospitalisation ... -
Three differently generated salmon protein hydrolysates reveal opposite effects on hepatic lipid metabolism in mice fed a high-fat diet
(Peer reviewed; Journal article, 2015-03-17)This study investigates the effects of salmon peptide fractions, generated using different enzymatic hydrolyzation methods, on hepatic lipid metabolism. Four groups of mice were fed a high-fat diet with 20% casein (control ... -
Thrombectomy in large vessel occlusion stroke—Does age matter?
(Journal article; Peer reviewed, 2022)Objectives Endovascular treatment (EVT) is the gold standard treatment for emergent large vessel occlusion (LVO). The benefit of EVT for emergent LVO in elderly patients (>80 years old) is still debated as they have been ... -
Thrombocytopaenia in the critically ill
(Journal article; Peer reviewed, 2021)