Blar i Department of Clinical Science på tittel
Viser treff 427-446 av 2294
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Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients
(Peer reviewed; Journal article, 2019-05-09)Background: Immunotherapy for patients with microsatellite-instable (MSI-H) tumors or BRAF-inhibitors combination treatment for BRAF-mutated (mutBRAF) tumors in metastatic colorectal cancer (mCRC) is promising, but the ... -
Consequences of refining biological networks through detailed pathway information : From genes to proteoforms
(Doctoral thesis, 2022-11-28)Biologiske nettverk kan brukes til å modellere molekylære prosesser, forstå sykdomsprogresjon og finne nye behandlingsstrategier. Denne avhandlingen har undersøkt hvordan utformingen av slike nettverk påvirker deres struktur, ... -
Conservation of Distinct Genetically-Mediated Human Cortical Pattern
(Peer reviewed; Journal article, 2016-07-26)The many subcomponents of the human cortex are known to follow an anatomical pattern and functional relationship that appears to be highly conserved between individuals. This suggests that this pattern and the relationship ... -
Conserved metabolic enzymes as vaccine antigens for giardiasis
(Journal article; Peer reviewed, 2022-04-25)Giardia lamblia is a leading protozoal cause of diarrheal disease worldwide. Infection is associated with abdominal pain, malabsorption and weight loss, and protracted post-infectious syndromes. A human vaccine is not ... -
Consistent biofilm formation by Streptococcus pyogenes emm 1 isolated from patients with necrotizing soft tissue infections
(Journal article; Peer reviewed, 2022-02-18)Objectives: Biofilm formation has been demonstrated in muscle and soft tissue samples from patients with necrotizing soft tissue infection (NSTI) caused by Streptococcus pyogenes, but the clinical importance of this ... -
Constitutional BRCA1 methylation and risk of incident triple-negative breast cancer and high-grade serous ovarian cancer
(Journal article; Peer reviewed, 2022)Importance About 25% of all triple-negative breast cancers (TNBCs) and 10% to 20% of high-grade serous ovarian cancers (HGSOCs) harbor BRCA1 promoter methylation. While constitutional BRCA1 promoter methylation has been ... -
The Constitutive Extracellular Protein Release by Acute Myeloid Leukemia Cells—A Proteomic Study of Patient Heterogeneity and Its Modulation by Mesenchymal Stromal Cells
(Journal article; Peer reviewed, 2021)Extracellular protein release is important both for the formation of extracellular matrix and for communication between cells. We investigated the extracellular protein release by in vitro cultured normal mesenchymal stem ... -
Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes
(Peer reviewed; Journal article, 2016-07-04)Background Expression of the androgen receptor (AR) is associated with androgen-dependent proliferation arrest and terminal differentiation of normal prostate epithelial cells. Additionally, activation of the AR is required ... -
Context-related biomarkers in endometrial cancer. A study with focus on obesity and genomic alterations
(Doctoral thesis, 2017-06-09)Background: Endometrial cancer is the most common female pelvic gynaecologic malignancy in industrialised countries, and incidence has been increasing over the past decades. This has partly been ascribed to the increasing ... -
Contextual factors influencing medicines-related interventions to support safe transitions for care home residents post hospital discharge: a systematic review and meta-ethnographic synthesis
(Journal article; Peer reviewed, 2022)Background Residents of care or nursing homes are at a higher risk of medication-related harm, especially during care transitions. No medicines-related intervention has been identified that supports the safe transition ... -
Continuation of fluoropyrimidine treatment with S-1 after cardiotoxicity on capecitabine- or 5-fluorouracil-based therapy in patients with solid tumours: a multicentre retrospective observational cohort study
(Journal article; Peer reviewed, 2022)Background Capecitabine- or 5-fluorouracil (5-FU)-based chemotherapy is widely used in many solid tumours, but is associated with cardiotoxicity. S-1 is a fluoropyrimidine with low rates of cardiotoxicity, but evidence ... -
Continuity of care after percutaneous coronary intervention: The patient's perspective across secondary and primary care settings
(Peer reviewed; Journal article, 2017)Background: Although patients may experience a quick recovery followed by rapid discharge after percutaneous coronary interventions (PCIs), continuity of care from hospital to home can be particularly challenging. Despite ... -
Continuity of care and its associations with self-reported health, clinical characteristics and follow-up services after percutaneous coronary intervention
(Journal article; Peer reviewed, 2020)Aims Complexity of care in patients with coronary artery disease is increasing, due to ageing, improved treatment, and more specialised care. Patients receive care from various healthcare providers in many settings. Still, ... -
Continuous positive airway pressure for bronchiolitis in a general paediatric ward; a feasibility study
(Peer reviewed; Journal article, 2014-05-12)Background: Continuous positive airway pressure (CPAP) is commonly used to relieve respiratory distress in infants with bronchiolitis, but has mostly been studied in an intensive care setting. Our prime aim was to evaluate ... -
Continuous Subcutaneous Hydrocortisone Infusion versus Oral Hydrocortisone Replacement for Treatment of Addison’s Disease: A Randomized Clinical Trial
(Peer reviewed; Journal article, 2014)Context: Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison’s disease. Objective: The objective ... -
Contrast stress echocardiography in hypertensive heart disease
(Peer reviewed; Journal article, 2011-11-18)Hypertension is associated with atherosclerosis and cardiac and vascular structural and functional changes. Myocardial ischemia may arise in hypertension independent of coronary artery disease through an interaction between ... -
The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations
(Journal article; Peer reviewed, 2023)Aims/hypothesis: We examined the contribution of rare HNF1A variants to type 2 diabetes risk and age of diagnosis, and the extent to which their impact is affected by overall genetic susceptibility, across three ancestry ... -
Conundrums in the breathless athlete; exercise-induced laryngeal obstruction or asthma?
(Journal article; Peer reviewed, 2022)Purpose: Exercise-induced bronchoconstriction (EIB) and exercise-induced laryngeal obstruction (EILO) are the two disorders commonly considered when athletes complain of exertional dyspnea. They are highly different but ... -
Convergence of virulence and MDR in a single plasmid vector in MDR Klebsiella pneumoniae ST15
(Peer reviewed; Journal article, 2019)Background: MDR and hypervirulence (hv) are typically observed in separate Klebsiella pneumoniae populations. However, convergent strains with both properties have been documented and potentially pose a high risk to public ... -
Coordination of Metabolism and Virulence Factors Expression of Extraintestinal Pathogenic Escherichia coli Purified from Blood Cultures of Patients with Sepsis
(Peer reviewed; Journal article, 2016-09)One of the trademarks of extraintestinal pathogenic Escherichia coli is adaptation of metabolism and basic physiology to diverse host sites. However, little is known how this common human pathogen adapts to permit survival ...