Blar i Department of Clinical Science på tittel
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Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III
(Peer reviewed; Journal article, 2019)Introduction: The fractional exhaled nitric oxide (FENO ) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors ... -
Determinants of interindividual variation in exercise-induced cardiac troponin I levels
(Journal article; Peer reviewed, 2021)Background: Postexercise cardiac troponin levels show considerable interindividual variations. This study aimed to identify the major determinants of this postexercise variation in cardiac troponin I (cTnI) following 3 ... -
Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes
(Journal article; Peer reviewed, 2021)Hundreds of thousands of genetic variants have been reported to cause severe monogenic diseases, but the probability that a variant carrier develops the disease (termed penetrance) is unknown for virtually all of them. ... -
Determination of conformations adopted by CXCR4 and CCR5 at the cell surface
(Master thesis, 2010-05-20)The chemokines and their receptors constitute many important physiological functions in the human body. The chemokine receptors belong to the family of G-protein coupled receptors, characterized by 7 α-helices penetrating ... -
Determination of lower cut-off levels of adalimumab associated with biochemical remission in Crohn's disease
(Peer reviewed; Journal article, 2020)Background and Aim: Adalimumab is administered and dosed using a standardized treatment regimen. Although therapeutic drug monitoring (TDM) may help optimize treatment efficacy, the lower cut‐off concentration of adalimumab ... -
Developing a core outcome set for hospital deprescribing trials for older people under the care of a geriatrician
(Journal article; Peer reviewed, 2022)Background Half of older people are prescribed unnecessary/inappropriate medications that are not routinely deprescribed in hospital hence there is a need for deprescribing trials. We aimed to develop a Core Outcome Set ... -
Developing a flow cytometric method to characterize human T cell responses against the enteric protozoan parasite Giardia lamblia
(Master thesis, 2014-06-03)Giardia lamblia is an enteric protozoan parasite, which causes infection in humans worldwide. The impact of the infection varies from asymptomatic carriers to severe disease such as malabsorption syndrome. Evidence for ... -
Development and external validation of prognostic models to predict sudden and pump-failure death in patients with HFrEF from PARADIGM-HF and ATMOSPHERE
(Journal article; Peer reviewed, 2021)Background: Sudden death (SD) and pump failure death (PFD) are the two leading causes of death in patients with heart failure and reduced ejection fraction (HFrEF). Objective: Identifying patients at higher risk for ... -
Development of a bioluminescent nitroreductase probe for preclinical imaging
(Peer reviewed; Journal article, 2015-06-25)Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In ... -
Development of a Disease-Specific Quality of Life Questionnaire in Addison’s Disease
(Peer reviewed; Journal article, 2010-02)Context: Patients with Addison’s disease reproducibly self-report impairment in specific dimensions of general well-being questionnaires, suggesting particular deficiencies in health-related quality-of-life (HRQoL). ... -
Development of a Framework and the Content for a Psychoeducational Internet-Delivered Intervention for Women after Treatment for Gynecological Cancer
(Journal article; Peer reviewed, 2021)The number of women treated for gynecological cancer is increasing. At the same time, the duration of in-patient hospitalization has decreased, and follow-up with its primary focus on early recognition of recurrence does ... -
Development of a novel, high-affinity ssDNA trypsin inhibitor
(Peer reviewed; Journal article, 2019)Inhibitors of serine proteases are not only extremely useful in the basic research but are also applied extensively in clinical settings. Using Systematic Evolution of Ligands by Exponential Enrichment (SELEX) approach we ... -
Development of functional gastrointestinal disorders after Giardia lamblia infection
(Peer reviewed; Journal article, 2009-04-21)Background: Functional gastrointestinal disorders (FGID) may occur following acute gastroenteritis. This long-term complication has previously not been described after infection with the non-invasive protozoan Giardia ... -
Development of liposomal nanoencapsulation of lumefantrine with phosphatidylcholine/Tweens system
(Master thesis, 2021-05-20) -
Development of lung diffusion to adulthood following extremely preterm birth
(Journal article; Peer reviewed, 2022)Background: Gas exchange in extremely preterm (EP) infants must take place in fetal lungs. Childhood lung diffusing capacity of the lung for carbon monoxide (DLCO) is reduced; however, longitudinal development has not been ... -
Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma
(Journal article; Peer reviewed, 2020-02-10)Background In endometrioid endometrial cancer (EEC), current clinical algorithms do not accurately predict patients with lymph node metastasis (LNM), leading to both under- and over-treatment. We aimed to develop models ... -
Development of UHPLC-MS/MS methods to quantify 25 antihypertensive drugs in serum in a cohort of patients treated for hypertension
(Journal article; Peer reviewed, 2022)We developed three ultra-high pressure liquid chromatography coupled to mass spectrometry detection (UHPLC-MS/MS) methods to quantify 25 antihypertensive drugs in serum samples. Patient-reported drug lists were collected, ... -
DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance
(Journal article; Peer reviewed, 2021)Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer ... -
Diabetes mellitus impact on fetal liver circulation, and new diagnostic options
(Journal article; Peer reviewed, 2023)While biometry and Doppler have proved useful in the management of fetal growth restriction, the same battery has been of less help in diabetic pregnancies. It is not surprising since the underlying pathophysiology is ... -
Diabetes mellitus type 2; The incretin effect and interaction with the autonomic nervous system
(Doctoral thesis, 2023-09-22)Bakgrunn: Inkretineffekten er kroppens evne til økt insulinsekresjon når glukose inntas peroralt sammenliknet med administrert intravenøst, utløst av spesifikke hormoner fra tarmen. En redusert inkretineffekt leder til ...