Blar i Department of Clinical Science på tittel
Viser treff 63-82 av 2396
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Amniotic fluid arginine from gestational weeks 13 to 15 is a predictor of birth weight, length, and head circumference
(Peer reviewed; Journal article, 2017-12-14)Arginine is a constituent of proteins and a precursor for polyamines and nitric oxide, and is essential for placentation, angiogenesis, and growth. Maternal plasma arginine concentrations are found to be lower in pregnancies ... -
AMPK som regulator av mitokondriell biogenese i en ny reporter-cellemodell
(Master thesis, 2011-08-31)I dette prosjektet studerte vi rollen til den cellulære energisensoren Adenosine Monophosphate Aktivert Protein Kinase (AMPK) ved mitokondriell biogenese i en ny reportercellemodell, HelaNRF1mitoGFP. To kjente AMPK agonister, ... -
Analyses of Increased Mortality in New and Known Diabetes in Patients with Coronary Disease Enrolled in the NORSTENT Randomized Study
(Journal article; Peer reviewed, 2021)Background: NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention with drug-eluting stents (DES) or bare-metal stents (BMS) with a 5-year follow-up. Among the patients, 5,512 had measured either ... -
Analysing microbiome intervention design studies: Comparison of alternative multivariate statistical methods
(Journal article; Peer reviewed, 2021)The diet plays a major role in shaping gut microbiome composition and function in both humans and animals, and dietary intervention trials are often used to investigate and understand these effects. A plethora of statistical ... -
Analysis of cellular and humoral immune responses against cytomegalovirus in patients with autoimmune Addison’s disease
(Peer reviewed; Journal article, 2016-03-09)Background. Autoimmune Addison’s disease (AAD) is caused by multiple genetic and environmental factors. Variants of genes encoding immunologically important proteins such as the HLA molecules are strongly associated with ... -
Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
(Peer reviewed; Journal article, 2018-12-11)Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern ... -
Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
(Journal article; Peer reviewed, 2022)Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ... -
Analytical considerations in deriving 99th percentile upper reference limits for high-sensitivity cardiac troponin assays: Educational recommendations from the IFCC committee on clinical application of cardiac bio-markers
(Journal article; Peer reviewed, 2022)The International Federation of Clinical Chemistry Committee on Clinical Application of Cardiac Bio-Markers provides evidence-based educational documents to facilitate uniform interpretation and utilization of cardiac ... -
Analytical performance of cardiac troponin assays – Current status and future needs
(Journal article; Peer reviewed, 2020)Concurrent with the introduction of cardiac troponin measurements into the diagnostic definition of myocardial infarction (MI), clinicians and laboratory professionals signaled a clear clinical need for improved analytical ... -
Anatomy and evolution of database search engines — a central component of mass spectrometry based proteomic workflows
(Peer reviewed; Journal article, 2017-09-13)Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass ... -
Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans
(Journal article; Peer reviewed, 2020-04)HOTAIR was proposed to regulate either HoxD cluster genes in trans or HoxC cluster genes in cis, a mechanism that remains unclear. We have identified a 32-nucleotide conserved noncoding element (CNE) as HOTAIR ancient ... -
Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival
(Peer reviewed; Journal article, 2017)Aneuploidy is a widely studied prognostic marker in endometrial cancer (EC), however, not implemented in clinical decision-making. It lacks validation in large prospective patient cohorts adjusted for currently standard ... -
Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome
(Journal article; Peer reviewed, 2021)Background Plasma levels of angiopoietin-2 (ANGPT2) and angiopoietin-like 4 protein (ANGPTL4) reflect different pathophysiological aspects of cardiovascular disease. We evaluated their association with outcome in a ... -
Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero
(Journal article; Peer reviewed, 2023)Introduction: Fetal growth may be affected by both maternal polycystic ovary syndrome (PCOS) and metformin therapy. Here, we explore the effect of intrauterine metformin exposure on birth anthropometrics of infants born ... -
Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn’s disease
(Journal article; Peer reviewed, 2021)Fatigue is common in all chronic inflammatory and autoimmune diseases. A conceptual model for understanding the biological basis of fatigue describes it as being a part of the sickness behaviour response generated by ... -
Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
(Peer reviewed; Journal article, 2006-06-13)Background The autoimmune regulator (AIRE) gene influences thymic self-tolerance induction. In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM 240300), recessive AIRE mutations lead to autoimmunity targetting ... -
Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia
(Peer reviewed; Journal article, 2016-12-01)Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome ... -
Antibiotic use at a tertiary hospital in Tanzania: findings from a point prevalence survey
(Journal article; Peer reviewed, 2023)Background In Tanzania, data on antibiotic use at the patient level is scarce, and intervention measures to optimize antibiotic use and reduce antimicrobial resistance are rarely performed. Objectives To describe ... -
Antibiotic Use in a Cohort of Norwegian Children and Neonates Before, During and After Hospitalisation : Exploring focus areas for antibiotic stewardship
(Doctoral thesis, 2022-11-22)Bakgrunn: Rasjonell antibiotikabruk blant barn er essensielt for å unngå økende antibiotikaresistens samt forstyrrelser i deres normale bakterieflora. Formål: Hensikten med dette prosjektet var å tilegne oss en bedre ... -
Antibiotic use in children before, during and after hospitalisation
(Journal article; Peer reviewed, 2022)Purpose: To investigate ambulatory antibiotic use in children during 1 year before and 1 year after in-hospital antibiotic exposure compared to children from the general population that had not received antibiotics ...