Browsing Faculty of Medicine by Title
Now showing items 4866-4885 of 8871
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Kvetiapinmisbruk - myte eller realitet?
(Journal article; Peer reviewed, 2020) -
Kvinners erfaringer med abortnemnder
(Research report, 2023)Denne rapporten presenterer resultatene fra en amfunnsvitenskapelig studie om kvinners erfaringer med abortnemnder. Rapporten bygger på 13 dybdeintervju med kvinner som hadde erfaring med å søke om og gjennomleve ... -
Kvite frakkar og kvite rom. Eit kvalitativt studie av kreftpasientar sine erfaringar av natur og arkitektur i sjukehusmiljø
(Master thesis, 2012-02-06)Bakgrunn: To bygg i Helse Bergen HF, Sentralblokka (1983) og Parkbygget (2008) gir konteksten i studiet. Sentralblokka står for ein arkitektur som sikrar rasjonelle driftsøkonomiske hensyn, der funksjonsanalyser blei brukt. ... -
The kynurenine pathway in cognition, dementia, and aging
(Doctoral thesis, 2021-06-16)Background: Experimental studies implicate the kynurenine pathway in cognitive function, dementia, aging, and longevity. Comparatively, clinical studies are few and most lack comprehensive targeted metabolomic profiling ... -
The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics
(Journal article; Peer reviewed, 2021)Scope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway. This ... -
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
(Journal article; Peer reviewed, 2022)The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine ... -
Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia
(Journal article; Peer reviewed, 2019)Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in ... -
Label-free impedance flow cytometry for nanotoxicity screening
(Peer reviewed; Journal article, 2020)The development of reliable and cost-efficient methods to assess the toxicity of nanomaterials (NMs) is critical for the proper identification of their impact on human health and for ensuring a safe progress of nanotechnology. ... -
Label-free monitoring of uptake and toxicity of endoprosthetic wear particles in human cell cultures
(Peer reviewed; Journal article, 2018)The evaluation of the biological effects of endoprosthetic wear particles on cells in vitro relies on a variety of test assays. However, most of these methods are susceptible to particle-induced interferences; therefore, ... -
Label-free quantitative proteomic analysis of the oral bacteria Fusobacterium nucleatum and Porphyromonas gingivalis to identify protein features relevant in biofilm formation
(Journal article; Peer reviewed, 2021)Background The opportunistic pathogens Fusobacterium nucleatum and Porphyromonas gingivalis are Gram-negative bacteria associated with oral biofilm and periodontal disease. This study investigated interactions between F. ... -
Labor epidural analgesia and subsequent risk of offspring autism spectrum disorder and attention-deficit/hyperactivity disorder: A cross-national cohort study of over 4.5 million individuals and their siblings in Finland, Norway, and Sweden
(Journal article; Peer reviewed, 2023)Background A recent study has suggested that labor epidural analgesia may be associated with increased rates of offspring autism spectrum disorder. Subsequent replication attempts have lacked sufficient power to confidently ... -
Laboratory contamination in airway microbiome studies
(Peer reviewed; Journal article, 2019-08-14)Background The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We have ... -
Laboratory tests in out-of-hours services in Norway. Studies with special emphasis on use and consequences of C-reactive protein test in children
(Doctoral thesis, 2017-05-31)Background: Children with infections and respiratory symptoms have the highest contact rate with Norwegian out-of-hours (OOH) services, especially in the youngest age group, and during the winter season. Many contacts are ... -
Labour onset and early labour. An exploration of first-time mothers’ and midwives’ experiences
(Doctoral thesis, 2011-10-28)This dissertation is about how women experience waiting for the onset of labour, and how first-time mothers and midwives communicate during the early phases of labour. Most women in Norway give birth in public hospitals, ... -
Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson’s Disease Cohorts
(Journal article; Peer reviewed, 2021)Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson’s disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on ... -
Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis
(Journal article; Peer reviewed, 2020)Liver and adipose tissues play important roles in the regulation of systemic glucose and lipid metabolism. Extracellular matrix synthesis and remodelling are significantly altered in these tissues in obesity and type 2 ... -
Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma
(Peer reviewed; Journal article, 2017)Neo-angiogenesis represents an important factor for the delivery of oxygen and nutrients to a growing tumour, and is considered to be one of the main pathodiagnostic features of glioblastomas (GBM). Anti-angiogenic therapy ... -
Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis
(Journal article; Peer reviewed, 2022)Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, ... -
Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients
(Journal article; Peer reviewed, 2021)Purpose: Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who have ... -
The laminin response in inflammatory bowel disease: Protection or malignancy?
(Peer reviewed; Journal article, 2014-10-27)Laminins (LM), basement membrane molecules and mediators of epithelial-stromal communication, are crucial in tissue homeostasis. Inflammatory Bowel Diseases (IBD) are multifactorial pathologies where the microenvironment ...