Browsing Faculty of Medicine by Title
Now showing items 4680-4699 of 8819
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Investigation of the apoptotic pathway in glioblastoma in the context of suicide gene therapy
(Master thesis, 2023-06-01)Glioblastoma is a highly malignant, aggressive and most common primary brain tumor in adults. Tremendous research efforts have been conducted in the field of GBM treatment discovery and succcess has only been achieved at ... -
Investigation of the Role of BCR/ABL1 in Neutrophil Extracellular Trap (NET) Formation in Chronic Myeloid Leukemia (CML)
(Master thesis, 2022-06-01)Neutrophil extracellular traps (NETs) represent a rather newly discovered antimicrobial mechanism first described by Brinkmann and co-workers in 2004. NETs are extracellular structures composed of decondensed chromatin ... -
Investigations of the cancer therapeutic and protective effects of warfarin-mediated inhibition of the receptor tyrosine kinase AXL
(Doctoral thesis, 2017-11-17)Cancer is a major health issue all over the world. Cancer related deaths are one of the major causes of deaths, and are in > 90 % of the cases related to metastatic development, and spread of the cancer outside the primary ... -
Involvement in emergency situations by primary care doctors on-call in Norway - a prospective population-based observational study
(Peer reviewed; Journal article, 2010-03-06)Background: Primary care doctors on-call in the emergency primary health care services in Norway are, together with the ambulances, the primary resources for handling emergencies outside hospitals. There is a lack of ... -
Involvement of the 14-3-3 Gene Family in Autism Spectrum Disorder and Schizophrenia: Genetics, Transcriptomics and Functional Analyses
(Journal article; Peer reviewed, 2020)The 14-3-3 protein family are molecular chaperones involved in several biological functions and neurological diseases. We previously pinpointed YWHAZ (encoding 14-3-3ζ) as a candidate gene for autism spectrum disorder (ASD) ... -
Involvement of the Private Retail Pharmacies in Pakistan Tuberculosis Control
(Master thesis, 2015-11-29)Tuberculosis is the second leading cause of death globally from a contagious disease. Pakistan is at 4th position among the twenty two high TB burden countries. National tuberculosis control programme (NTP) Pakistan has ... -
Involving people with diabetes and the wider community in diabetes research: a realist review protocol
(Peer reviewed; Journal article, 2015-11-04)Background: Patient and public involvement in diabetes research is now actively encouraged in different countries because it is believed that involving people with experience of the condition will improve the quality and ... -
Iodine concentration in breastmilk and urine among lactating women of Bhaktapur, Nepal
(Peer reviewed; Journal article, 2016-04-28)Adequate iodine concentration in breastmilk (BMIC) is essential for optimal neonatal thyroid hormone synthesis and neurological development in breastfed infants. For many decades, iodine deficiency has been a public health ... -
Iodine content of dietary supplements available on the Norwegian market
(Master thesis, 2021-05-18)Background: Insufficient iodine intake has been reported in groups of the Norwegian population. This is of concern, as iodine is an essential nutrient required throughout life. With few dietary sources of iodine, supplementation ... -
Iodine deficiency in a study population of Norwegian pregnant women - results from the Little in Norway study (LiN)
(Peer reviewed; Journal article, 2018-04-20)Iodine sufficiency is particularly important in pregnancy, where median urinary iodine concentration (UIC) in the range of 150–250 µg/L indicates adequate iodine status. The aims of this study were to determine UIC and ... -
Iodine Nutrition and Iodine Supplement Initiation in Association with Thyroid Function in Mildly-to-Moderately Iodine-Deficient Pregnant and Postpartum Women
(Journal article; Peer reviewed, 2021)Background: Whereas the adverse effects of severe iodine deficiency during pregnancy are well documented, the effects of mild-to-moderate deficiency are not well established. Objectives: We aimed to explore whether ... -
Iodine Nutrition and Thyroid Function in Habitual Seaweed Consumers at Baseline and after a 6-week Cessation of Seaweed Intake
(Master thesis, 2023-05-15)Bakgrunn/introduksjon: Tang og tare, eller makroalger, har blitt mer og mer populært i vesten de siste årene. Makroalger kan være kilder til jod, men inter- og intraartsvariabilitet i jodnivåer kan også føre til overflødige ... -
Iodine Nutrition in Children ≤2 years of Age in Norway
(Journal article; Peer reviewed, 2023)Background As a component of the thyroid hormones (THs), iodine is vital for normal neurodevelopment during early life. However, both deficient and excess iodine may affect TH production, and data on iodine status in ... -
Iodine status and thyroid function in a group of seaweed consumers in Norway
(Journal article; Peer reviewed, 2020)Seaweeds, or macroalgae, may be a good dietary iodine source but also a source of excessive iodine intake. The main aim in this study was to describe the iodine status and thyroid function in a group of macroalgae consumers. ... -
Iodine status in Norwegian preschool children and associations with dietary iodine sources: the FINS-KIDS study
(Peer reviewed; Journal article, 2018)Purpose. Iodine is an essential trace element necessary for thyroid hormone synthesis. Iodine deficiency is a continuing public health problem despite international efforts to eliminate it. Studies on iodine status in ... -
Iodine status in Norwegian preschool children and significance of dietary sources of iodine and parental socio-economic factors - A cross-sectional study
(Master thesis, 2016-05-15)Iodine is an essential trace element with important physiological effects in the human body. Iodine is necessary for thyroid hormone synthesis. The hormones are needed for tissue development in the central nervous system, ... -
Iodine status in women attending Mnazi Mmoja Hospital in Zanzibar: a matched case-control study
(Journal article; Peer reviewed, 2021)Background Iodine deficiency can have adverse health effects in all age groups affecting growth, development and cognitive functions as well as the incidence of goitre. Worldwide, the most important dietary source of ... -
Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells
(Peer reviewed; Journal article, 2013-01-30)Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a ... -
Ionic strength and calcium regulate membrane interactions of myelin basic protein and the cytoplasmic domain of myelin protein zero
(Peer reviewed; Journal article, 2019)The formation of a mature myelin sheath in the vertebrate nervous system requires specific protein-membrane interactions. Several myelin-specific proteins are involved in stacking lipid membranes into multilayered structures ...