Browsing Faculty of Medicine by Title
Now showing items 645-664 of 8821
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Awareness and prevalence of acute mountain sickness and prevalence of obstructive airflow limitation among Nepalese porters: A cross-sectional study in Khumbu Valley, Nepal
(Master thesis, 2009-06-26)Background: Acute mountain sickness is a major public health problem in high altitudes. Similarly, anecdotal evidence suggests that there is high prevalence of tobacco smoking among this group though prevalence of obstructive ... -
Axes of alienation: applying an intersectional lens on the social contract during the pandemic response to protect sexual and reproductive rights and health
(Journal article; Peer reviewed, 2020)While economic inequalities have been a key focus of attention through the COVID 19 pandemic, gendered relations of power at every level have undermined health rights of women, girls and gender diverse individuals. Sexual ... -
AXL is a driver of stemness in normal mammary gland and breast cancer
(Journal article; Peer reviewed, 2020)The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of ... -
AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells
(Journal article; Peer reviewed, 2020)Introduction Acquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell survival and immune evasion. AXL receptor tyrosine ... -
AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model
(Journal article; Peer reviewed, 2021)AXL tyrosine kinase activation enhances cancer cell survival, migration, invasiveness, and promotes drug resistance. AXL overexpression is typically detected in a high percentage of renal cell carcinomas (RCCs) and is ... -
AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction
(Peer reviewed; Journal article, 2019)The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial-tomesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL ... -
AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells
(Journal article; Peer reviewed, 2022)Mutations in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB), and introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas ... -
Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model
(Journal article; Peer reviewed, 2021)Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase ... -
"Å leve med visshet om Huntingtons sykdom" : En kvalitativ studie om erfaringer med å ha testet positivt på presymptomatisk test for Huntingtons sykdom
(Master thesis, 2010-05-16)Huntington's disease is a severe, dominantly inherited disease in which there is no curative treatment for. A person at risk can take a pre-symptomatic test that provides a safe answer if the person has inherited the ... -
B cell specificity and pattern in primary Sjögren’s syndrome - Studies in humans and a murine model
(Doctoral thesis, 2014-04-30)Sjögren’s syndrome (SS) is a chronic autoimmune disease characterised by focal inflammation of exocrine glands, particularly salivary and lacrimal glands. Here, mononuclear cells, including B cells, infiltrate the glands, ... -
B cells and autoantibodies in AIRE deficiency
(Journal article; Peer reviewed, 2021)Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare but severe monogenetic autoimmune endocrine disease caused by failure of the Autoimmune Regulator (AIRE). AIRE regulates the negative selection of T cells in the ... -
B vitamin and iron status during infancy
(Doctoral thesis, 2015-01-30)Adequate nutrition during infancy is essential to ensure normal growth and development. Since 2001, World Health Organization (WHO) has recommended exclusive breast-feeding for the first 6 months of life, which puts great ... -
B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris
(Peer reviewed; Journal article, 2016-06)Background: Methylenetetrahydrofolate dehydrogenase (MTHFD1) catalyzes three sequential reactions that metabolize derivatives of tetrahydrofolate (THF) in folate-dependent one-carbon metabolism. Impaired MTHFD1 flux has ... -
The B-lymphocyte chemokine CXCL13 in the cerebrospinal fluid of children with Lyme neuroborreliosis: associations with clinical and laboratory variables
(Peer reviewed; Journal article, 2019)Background: The B-lymphocyte chemokine CXCL13 is increasingly considered as a useful early phase diagnostic marker of Lyme neuroborreliosis (LNB). However, the large variation in level of CXCL13 in the cerebrospinal fluid ... -
B-type natriuretic peptide and high sensitive C-reactive protein predict 2-year all cause mortality in chest pain patients: a prospective observational study from Salta, Argentina
(Peer reviewed; Journal article, 2011-09-29)Background: Several mechanisms are involved in the pathophysiology of the Acute Coronary Syndrome (ACS). We have addressed whether B-type natriuretic peptide (BNP) and high-sensitive C-reactive protein (hsCRP) in admission ... -
B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion
(Peer reviewed; Journal article, 2015-04)Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ... -
B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study
(Journal article; Peer reviewed, 2023)Background Calcium channel blockers (CCBs) are used for the treatment of cardiovascular disease (CVD), including angina pectoris, and hypertension; however, the effect on survival remains uncertain. CCBs impair fibrinolysis ... -
“Back to Eden”: An explorative qualitative study on traditional medicine use during pregnancy among selected women in Lusaka Province, Zambia
(Journal article; Peer reviewed, 2020)Background and purpose: No qualitative study on traditional medicine use among Zambian pregnant women has ever been conducted. Accordingly, this study was performed to explore the perceptions, motivations and experiences ... -
Bacteraemia among severely malnourished children infected and uninfected with the human immunodeficiency virus-1 in Kampala, Uganda
(Peer reviewed; Journal article, 2006-11-07)Background: To establish the magnitude of bacteraemia in severely malnourished children, and describe the types of bacteria and antimicrobial sensitivity by HIV status. Method: Isolates were recovered from 76 blood specimens. ... -
Bacteraemia, Malaria, and Case Fatality Among Children Hospitalized With Fever in Dar es Salaam, Tanzania
(Journal article; Peer reviewed, 2020)Background: Febrile illness is the commonest cause of hospitalization in children <5 years in sub-Saharan Africa, and bacterial bloodstream infections and malaria are major causes of death. Methods: From March 2017 to ...