Browsing Department of Clinical Science by Title
Now showing items 1174-1193 of 2377
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In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins
(Peer reviewed; Journal article, 2017)Spinocerebellar ataxia, autosomal recessive 16 (SCAR16) is caused by biallelic mutations in the STIP1 homology and U-box containing protein 1 (STUB1) gene encoding the ubiquitin E3 ligase and dimeric co-chaperone C-terminus ... -
In Vitro Characterization of Valproic Acid, ATRA, and Cytarabine Used for Disease-Stabilization in Human Acute Myeloid Leukemia: Antiproliferative Effects of Drugs on Endothelial and Osteoblastic Cells and Altered Release of Angioregulatory Mediators by Endothelial Cells.
(Peer reviewed; Journal article, 2014-01-08)The combined use of the histone deacetylase inhibitor valproic acid (VPA), the retinoic acid receptor-α agonist all-trans retinoic acid (ATRA), and the deoxyribonucleic acid polymerase-α inhibitor cytarabine (Ara-C) is now ... -
In vitro cytotoksisk effekt av venom fra vestlig honningbie (Apis mellifera) hos glioblastoma cellelinjer av typen U251 og C6.
(Master thesis, 2008-06-01)Flere in vitro-metoder kan benyttes til å evaluere både generell og organspesifikk toksisitet. Disse metodene kan kombineres med bioprospektering for å screene mulige legemidler for cytotoksisk effekt, og samtidig begrense ... -
In vitro quality of cold and delayed cold-stored platelet concentrates from interim platelet units during storage for 21 days
(Journal article; Peer reviewed, 2023)Background and Objectives: Based on previous success using apheresis platelets, we wanted to investigate the in vitro quality and platelet function in continuously cold-stored and delayed cold-stored platelet concentrates ... -
In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome
(Peer reviewed; Journal article, 2013-09-09)Introduction: Therapeutic vaccination with antigen-specific tolerogenic dendritic cells (tolDC) might become a future option of individualized therapy for patients with autoimmune diseases. In this study, we tested the ... -
In vivo biodistribution of fluorescent nanocolloids intended for drug delivery - Evaluation of PEGylation state and fluorophore incorporation approach.
(Master thesis, 2012-05-31)To move the use of PLGA nanocolloids from laboratories towards the use in humans require careful investigations around pharmacokinetics and biodistributions. The biodistributions of the nanocolloids can be traced through ... -
In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism
(Journal article; Peer reviewed, 2020)Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating ... -
In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress
(Peer reviewed; Journal article, 2020)Aim: The loss of insulin‐secreting β‐cells, ultimately characterizing most diabetes forms, demands the development of cell replacement therapies. The common endpoint for all ex vivo strategies is transplantation into ... -
Incidence and Prognostic Significance of the Segond Fracture in Patients Undergoing Anterior Cruciate Ligament Reconstruction
(Journal article; Peer reviewed, 2020)Background: The Segond fracture is an avulsion of the anterolateral tibia that can be found in patients with an anterior cruciate ligament (ACL) tear. It is currently unclear if the Segond fracture needs treatment or if ... -
Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT)
(Journal article; Peer reviewed, 2021)Introduction Bleeding is a concern after percutaneous coronary intervention (PCI) and subsequent dual antiplatelet therapy (DAPT). We herein report the incidence and risk factors for major bleeding in the Norwegian ... -
Incidence of newborn resuscitative interventions at birth and short-term outcomes: A regional population-based study
(Peer reviewed; Journal article, 2019)Objectives: To determine the incidence and characteristics of resuscitative interventions at different gestational ages and short-term outcomes after resuscitation. Design, setting and patients: A prospective observational ... -
Incidence of thrombotic complications in hospitalised and non-hospitalised patients after COVID-19 diagnosis
(Journal article; Peer reviewed, 2021)Infection with coronavirus disease-2019 (COVID-19) may predispose for venous thromboembolism (VTE). There is wide variation in reported incidence rates of VTE in COVID-19, ranging from 3% to 85%. Therefore, the true incidence ... -
Incidence of tuberculosis among school-going adolescents in South India
(Peer reviewed; Journal article, 2016-07-26)Background: Tuberculosis (TB) incidence data in vaccine target populations, particularly adolescents, are important for designing and powering vaccine clinical trials. Little is known about the incidence of tuberculosis ... -
Incidence of tuberculosis and the influence of surveillance strategy on tuberculosis case-finding and all-cause mortality: A cluster randomised trial in Indian neonates vaccinated with BCG
(Peer reviewed; Journal article, 2019)Introduction: Accurate tuberculosis (TB) incidence and optimal surveillance strategies are pertinent to TB vaccine trial design. Infants are a targeted population for new TB vaccines, but data from India, with the highest ... -
Incidence of utilization- and symptom-defined COPD exacerbations in hospital- and population-recruited patients
(Peer reviewed; Journal article, 2016-09)Objectives: The objectives of this study were to estimate the impact of recruitment source and outcome definition on the incidence of acute exacerbations of COPD (AECOPD) and explore possible predictors of AECOPD. Patients ... -
Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis
(Peer reviewed; Journal article, 2017-07)Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug ... -
Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe
(Peer reviewed; Journal article, 2014-07-21)Background: One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data ... -
Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation
(Journal article; Peer reviewed, 2022)Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ... -
Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity
(Peer reviewed; Journal article, 2016-08-02)Background: To examine whether delirium in hip fracture patients was associated with changes in the levels of amino acids and/or monoamine metabolites in cerebrospinal fluid (CSF) and serum. Methods: In this prospective ...