Browsing Department of Clinical Science by Title
Now showing items 50-69 of 2316
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Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis
(Journal article; Peer reviewed, 2022)Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can lead to cirrhosis and hepatic decompensation. However, predicting future outcomes in patients with PSC is challenging. Our ... -
All-Optical Electrophysiology in hiPSC-Derived Neurons With Synthetic Voltage Sensors
(Journal article; Peer reviewed, 2021)Voltage imaging and “all-optical electrophysiology” in human induced pluripotent stem cell (hiPSC)-derived neurons have opened unprecedented opportunities for high-throughput phenotyping of activity in neurons possessing ... -
Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients
(Peer reviewed; Journal article, 1992-11)We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot ... -
Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations
(Peer reviewed; Journal article, 2019-02)Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of ... -
Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study
(Journal article; Peer reviewed, 2023)Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood. Design: Cross-sectional study. Methods: We compared serum ... -
Altered development of fetal liver perfusion in pregnancies with pregestational diabetes
(Peer reviewed; Journal article, 2019-03-13)Background: Pregestational diabetes is associated with fetal macrosomia, and umbilical perfusion of the fetal liver has a role in regulating fetal growth. We therefore hypothesized that pregestational diabetes alters fetal ... -
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
(Journal article; Peer reviewed, 2021)Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ... -
Altered immune activation and IL-23 signaling in response to Candida albicans in autoimmune polyendocrine syndrome type 1
(Peer reviewed; Journal article, 2017-09-01)Objective: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare, childhood onset disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis (CMC) is one of the three major ... -
Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome
(Peer reviewed; Journal article, 2014-08-11)Introduction: Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system, involved in both initiating immune responses and maintaining tolerance. Dysfunctional and via toll-like receptor (TLR) ... -
Alveolar function following extremely preterm birth
(Doctoral thesis, 2022-12-16)Bakgrunn: Ekstremt prematur (EP) fødsel skjer før normal lungeutvikling er fullført, og forstyrrer vekst og differensiering av alveolene. Mindre areal og tykkere membraner i alveolene gjør at lungenes evne til å drive ... -
Amniotic fluid arginine from gestational weeks 13 to 15 is a predictor of birth weight, length, and head circumference
(Peer reviewed; Journal article, 2017-12-14)Arginine is a constituent of proteins and a precursor for polyamines and nitric oxide, and is essential for placentation, angiogenesis, and growth. Maternal plasma arginine concentrations are found to be lower in pregnancies ... -
AMPK som regulator av mitokondriell biogenese i en ny reporter-cellemodell
(Master thesis, 2011-08-31)I dette prosjektet studerte vi rollen til den cellulære energisensoren Adenosine Monophosphate Aktivert Protein Kinase (AMPK) ved mitokondriell biogenese i en ny reportercellemodell, HelaNRF1mitoGFP. To kjente AMPK agonister, ... -
Analyses of Increased Mortality in New and Known Diabetes in Patients with Coronary Disease Enrolled in the NORSTENT Randomized Study
(Journal article; Peer reviewed, 2021)Background: NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention with drug-eluting stents (DES) or bare-metal stents (BMS) with a 5-year follow-up. Among the patients, 5,512 had measured either ... -
Analysing microbiome intervention design studies: Comparison of alternative multivariate statistical methods
(Journal article; Peer reviewed, 2021)The diet plays a major role in shaping gut microbiome composition and function in both humans and animals, and dietary intervention trials are often used to investigate and understand these effects. A plethora of statistical ... -
Analysis of cellular and humoral immune responses against cytomegalovirus in patients with autoimmune Addison’s disease
(Peer reviewed; Journal article, 2016-03-09)Background. Autoimmune Addison’s disease (AAD) is caused by multiple genetic and environmental factors. Variants of genes encoding immunologically important proteins such as the HLA molecules are strongly associated with ... -
Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
(Peer reviewed; Journal article, 2018-12-11)Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern ... -
Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
(Journal article; Peer reviewed, 2022)Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ... -
Analytical considerations in deriving 99th percentile upper reference limits for high-sensitivity cardiac troponin assays: Educational recommendations from the IFCC committee on clinical application of cardiac bio-markers
(Journal article; Peer reviewed, 2022)The International Federation of Clinical Chemistry Committee on Clinical Application of Cardiac Bio-Markers provides evidence-based educational documents to facilitate uniform interpretation and utilization of cardiac ... -
Analytical performance of cardiac troponin assays – Current status and future needs
(Journal article; Peer reviewed, 2020)Concurrent with the introduction of cardiac troponin measurements into the diagnostic definition of myocardial infarction (MI), clinicians and laboratory professionals signaled a clear clinical need for improved analytical ... -
Anatomy and evolution of database search engines — a central component of mass spectrometry based proteomic workflows
(Peer reviewed; Journal article, 2017-09-13)Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass ...