Blar i Department of Clinical Science på tittel

Viser treff 1314-1333 av 2318

    • Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature 

      Rafaelsen, Silje Hjorth; Johansson, Stefan; Ræder, Helge; Bjerknes, Robert (Peer reviewed; Journal article, 2014-09-24)
      Background: Hyperphosphatemic Familial Tumoral Calcinosis (HFTC) and Hyperphosphatemic Hyperostosis Syndrome (HHS) are associated with autosomal recessive mutations in three different genes, FGF23, GALNT3 and KL, leading ...

    • Long-term effect of cognitive–behavioural therapy in patients with Hypochondriacal Disorder 

      Veddegjærde, Kari-Elise Frøystad; Sivertsen, Børge; Skogen, Jens Christoffer; Smith, Otto Robert Frans; Wilhelmsen, Ingvard (Journal article; Peer reviewed, 2020)
      Background Cognitive–behavioural therapy (CBT) is an effective treatment for Hypochondriacal Disorder, but the long-term effect has not been examined extensively. Aims To investigate the long-term effect of CBT on ...

    • Long-Term Effectiveness and Safety of Childhood Growth Hormone Treatment in Noonan Syndrome 

      Rohrer, Tilman R.; Abuzzahab, Jennifer; Backeljauw, Philippe; Birkegård, Anna Camilla; Blair, Joanna; Dahlgren, Jovanna; Juliusson, Petur Benedikt; Ostrow, Vlady; Pietropoli, Alberto; Polak, Michel; Romanov, Alicia; Ross, Judith; Sävendahl, Lars; Miller, Bradley S. (Journal article; Peer reviewed, 2021)
      Introduction: Few data exist on long-term growth hormone (GH) treatment in patients with Noonan syndrome (NS). Objective: To evaluate the effectiveness and safety of GH treatment in NS in clinical practice. Methods: Height ...

    • Long-term follow-up after surgery for atrial fibrillation with concomitant open heart surgery 

      Andersen, Knut Sverre; Grong, Ketil; Hoff, Per-Ivar; Waba, Alexander (Journal article; Peer reviewed, 2021)
      BACKGROUND Patients with atrial fibrillation and atrial flutter scheduled to undergo open heart surgery can receive ablation treatment of arrhythmogenic foci during the same intervention. Sinus rhythm is restored in the ...

    • Long-term impact of gastropexy on use of acid-reducing medication, second operations for gastroesophageal reflux and subjective reflux symptoms after sleeve gastrectomy 

      Flølo, Tone Nygaard; Fosså, Alexander; Nedkvitne, Jonas Ingolf Petersson; Waage, Jo Erling Riise; Rekdal, Magne; Dankel, Simon N; Fernø, Johan; Mellgren, Gunnar; Nedrebø, Bjørn Gunnar (Journal article; Peer reviewed, 2023)
      We investigated whether adding gastropexy to sleeve gastrectomy (SG) reduced gastroesophageal reflux disease (GERD) in patients operated for severe obesity, assessed mainly by use of anti-reflux medication (ARM) and second ...

    • Long-Term Outcomes of Invasive vs Conservative Strategies for Older Patients With Non–ST-Segment Elevation Acute Coronary Syndromes 

      Berg, Erlend; Tegn, Nicolai Kloumann; Abdelnoor, Michael; Ryalen, Pål Christie; Røysland, Kjetil; Aaberge, Lars; Eek, Christian; Øie, Erik Harald; Juliebø, Vibeke; Gjertsen, Erik; Ranhoff, Anette Hylen; Gullestad, Lars; Nordstrand, Njord; Bendz, Bjørn (Journal article; Peer reviewed, 2023)
      Background Non–ST-segment elevation acute coronary syndrome (NSTE-ACS) is a frequent cause of hospital admission in older people, but clinical trials targeting this population are scarce. Objectives The After Eighty ...

    • Long-term prognosis in chronic primary glomerulonephritides 

      Bjørneklett, Rune Oskar (Doctoral thesis, 2012-03-15)
      Chronic primary glomerulonephritides (CPGN) is a group of diseases characterised by leakage of proteins and/or erythrocytes into the urine with or without decreased glomerular filtration rate (GFR), hypertension, oedema, ...

    • Long-term Respiratory Outcomes of Extreme Preterm Birth. A regional cohort study 

      Vollsæter, Maria (Doctoral thesis, 2016-04-22)
      Background: Survival after extremely preterm (EP) birth has increased considerably during the last three decades. The lifetime respiratory prospects for survivors are unknown. Aim: To study long-term respiratory health ...

    • Long-term temporal trends in incidence rate and case fatality of sepsis and COVID-19-related sepsis in Norwegian hospitals, 2008-2021: a nationwide registry study 

      Skei, Nina Vibeche; Nilsen, Tom Ivar Lund; Knoop, Siri Tandberg; Prescott, Hallie; Lydersen, Stian; Mohus, Randi Marie; Brkic, Alen; Liyanarachi, Kristin Vardheim; Solligård, Erik; Damås, Jan Kristian; Gustad, Lise Tuset (Journal article; Peer reviewed, 2023)
      Objectives: To estimate temporal trends in incidence rate (IR) and case fatality during a 14-year period from 2008 to 2021, and to assess possible shifts in these trends during the COVID-19 pandemic. Setting: All Norwegian ...

    • Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat 

      Strand, Elin; Bjørndal, Bodil; Nygård, Ottar; Burri, Lena; Berge, Christ; Bohov, Pavol; Christensen, Bjørn Jostein; Berge, Kjetil; Wergedahl, Hege; Viste, Asgaut; Berge, Rolf Kristian (Peer reviewed; Journal article, 2012-06-27)
      Background: Excess peroxisome proliferator-activated receptor (PPAR) stimulation has been associated with detrimental health effects including impaired myocardial function. Recently, supplementation with n-3 polyunsaturated ...

    • A longitudinal follow-up of autoimmune polyendocrine syndrome type 1 

      Bruserud, Øyvind; Oftedal, Bergithe Eikeland; Landegren, Nils; Erichsen, Martina Moter; Bratland, Eirik; Lima, Kari; Jørgensen, Anders Palmstrøm; Myhre, Anne Grethe; Svartberg, Johan; Fougner, Kristian J; Bakke, Åsne; Nedrebø, Bjørn Gunnar; Mella, Bjarne; Breivik, Lars Ertesvåg; Viken, Marte K; Knappskog, Per; Cuida Marthinussen, Ileana Mihaela; Løvås, Kristian; Kämpe, Olle; Wolff, Anette Susanne Bøe; Husebye, Eystein Sverre (Peer reviewed; Journal article, 2016-08)
      Context: Autoimmune polyendocrine syndrome type 1 (APS1) is a childhood-onset monogenic disease defined by the presence of two of the three major components: hypoparathyroidism, primary adrenocortical insufficiency, and ...

    • A longitudinal study of the pulmonary mycobiome in subjects with and without chronic obstructive pulmonary disease 

      Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal Lind; Wiker, Harald Gotten; Leiten, Elise Orvedal; Husebø, Gunnar Reksten; Knudsen, Kristel Svalland; Tangedal, Solveig; Sanseverino, Walter; Paytuví-Gallart, Andreu; Nielsen, Rune (Journal article; Peer reviewed, 2022-05-12)
      Background: Few studies have examined the stability of the pulmonary mycobiome. We report longitudinal changes in the oral and pulmonary mycobiome of participants with and without COPD in a large-scale bronchoscopy study ...

    • Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for Schizophrenia 

      Akkouh, Ibrahim Ahmed; Ueland, Thor; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Andreassen, Ole; Requena Osete, Jordi; Djurovic, Srdjan (Journal article; Peer reviewed, 2024)
      Background Schizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate ...

    • Longterm follow-up in European respiratory health studies - patterns and implications 

      Johannessen, Ane; Verlato, Guiseppe; Benediktsdottir, Bryndis; Forsberg, Bertil; Franklin, Karl; Gíslason, Thorainn; Holm, Mathias; Janson, Christer; Jögi, Rain; Lindberg, Eva; Macsali, Ferenc; Omenaas, Ernst; Gomez Real, Francisco; Saure, Eirunn Waatevik; Schlünssen, Vivi; Sigsgaard, Torben; Skorge, Trude Duelien; Svanes, Cecilie; Torén, Kjell; Waatevik, Marie Johanne; Nilsen, Roy Miodini; de Marco, Roberto (Peer reviewed; Journal article, 2014-04-16)
      Background: Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection ...

    • Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway 

      Wang, Shan; Rhijn, Jon-Ruben van; Akkouh, Ibrahim Ahmed; Kogo, Naoki; Maas, Nadine; Bleeck, Anna; Ortiz, Irene Santisteban; Lewerissa, Elly; Wu, Ka Man; Schoenmaker, Chantal; Djurovic, Srdjan; van Bokhoven, Hans; Kleefstra, Tjitske; Nadif Kasri, Nael; Schubert, Dirk (Journal article; Peer reviewed, 2022)
      Heterozygous loss-of-function (LoF) mutations in SETD1A, which encodes a subunit of histone H3 lysine 4 methyltransferase, cause a neurodevelopmental syndrome and increase the risk for schizophrenia. Using CRISPR-Cas9, we ...

    • Low BMI, but not high BMI, influences the timing of puberty in boys 

      Oehme, Ninnie Helen Bakken; Roelants, Mathieu; Bruserud, Ingvild Særvold; Madsen, Andre; Bjerknes, Robert; Rosendahl, Karen; Juliusson, Pétur Benedikt (Journal article; Peer reviewed, 2021)
      Background Previous studies investigating the association between weight status and onset of puberty in boys have been equivocal. It is currently unclear to what extent weight class influences puberty onset and ...

    • Low expression levels of ATM may substitute for CHEK2 / TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer 

      Knappskog, Stian; Chrisanthar, Ranjan; Løkkevik, Erik; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Risberg, Terje; Mjaaland, Ingvil; Leirvaag, Beryl; Miletic, Hrvoje; Lønning, Per Eystein (Peer reviewed; Journal article, 2012-03-15)
      Introduction: Mutations affecting p53 or its upstream activator Chk2 are associated with resistance to DNAdamaging chemotherapy in breast cancer. ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 and ...

    • Low fibre intake is associated with gut microbiota alterations in chronic heart failure 

      Mayerhofer, Cristiane C.K.; Kummen, Martin; Holm, Kristian; Broch, Kaspar; Awoyemi, Ayodeji Olawale; Vestad, Beate; Larsen, Christopher Storm; Seljeflot, Ingebjørg; Ueland, Thor; Bohov, Pavol; Berge, Rolf Kristian; Svardal, Asbjørn M.; Gullestad, Lars; Yndestad, Arne; Aukrust, Pål; Hov, Johannes Espolin Roksund; Trøseid, Marius (Journal article; Peer reviewed, 2020)
      Aims Recent reports have suggested that patients with heart failure (HF) have an altered gut microbiota composition; however, associations with diet remain largely uninvestigated. We aimed to explore differences in the ...

    • Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids 

      Yasinska, Valentyna; Gómez, Cristina; Kolmert, Johan; Ericsson, Magnus; Pohanka, Anton; James, Anna; Andersson, Lars I.; Sparreman-Mikus, Maria; Sousa, Ana R.; Riley, John H.; Bates, Stewart; Bakke, Per S.; Kermani, Nazanin Zounemat; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J.; Geiser, Thomas; Howarth, Peter H.; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Behndig, Annelie; Shaw, Dominick E.; Knowles, Richard G.; Dahlén, Barbro; van der Zee, Anke-Hilse Maitland; Sterk, Peter J.; Djukanovic, Ratko; Adcock, Ian M.; Chung, Kian Fan; Wheelock, Craig E.; Dahlén, Sven-Erik; Jonsson, Eva Wikström (Journal article; Peer reviewed, 2023)
      Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) ...

    • Low Levels of the Omega-3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase 

      Aarsetøy, Hildegunn; Aarsetøy, Reidun; Lindner, Thomas Werner; Staines, Harry; Harris, William S.; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2011-01-14)
      In previous studies, low blood levels of n-3 fatty acids (FA) have been associated with increased risk of cardiac death, and the omega-3 index (red blood cell (RBC) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) ...