Blar i Department of Clinical Science på tittel

Viser treff 1898-1917 av 2317

    • Reliability of maximum oxygen uptake in cardiopulmonary exercise testing with continuous laryngoscopy 

      Engan, Mette; Jansrud, Ida; Bekken, Marianne; Halvorsen, Thomas; Fretheim-Kelly, Zoe Louise; Vollsæter, Maria; Bovim, Lars Peder Vatshelle; Røksund, Ola Drange; Clemm, Hege Havstad (Journal article; Peer reviewed, 2020)
      Aims: A cardiopulmonary exercise test (CPET) is the gold standard to evaluate symptom-limiting exercise intolerance, while continuous laryngoscopy performed during exercise (CLE) is required to diagnose exercise-induced ...

    • Reliability of translaryngeal airway resistance measurements during maximal exercise 

      Fretheim-Kelly, Zoe; Engan, Mette; Clemm, Hege Synnøve Havstad; Andersen, Tiina Maarit; Heimdal, John-Helge; Strand, Eric; Halvorsen, Thomas; Røksund, Ola Drange; Vollsæter, Maria (Journal article; Peer reviewed, 2022)
      Objective Exercise-induced laryngeal obstruction is an important cause of exertional dyspnoea. The diagnosis rests on visual judgement of relative changes of the laryngeal inlet during continuous laryngoscopy exercise (CLE) ...

    • Remote magnetic versus manual catheters: evaluation of ablation effect in atrial fibrillation by myocardial marker levels 

      Solheim, Eivind; Off, Morten Kristian; Hoff, Per Ivar; De Bortoli, Alessandro; Schuster, Peter; Ohm, Ole-Jørgen; Chen, Jian (Peer reviewed; Journal article, 2011-04-08)
      Background A remote magnetic navigation (MN) system is available for radiofrequency ablation of atrial fibrillation (AF), challenging the conventional manual ablation technique. The myocardial markers were measured to ...

    • Renal function, sex and age influence purines and pyrimidines in urine and could lead to diagnostic misinterpretation 

      Salvador, Cathrin Lytomt; Flemmen, Per Tryggve Kjelland; Tøndel, Camilla; Bliksrud, Yngve Thomas; Tsui, Ellen Fun Fong; Brun, Atle; Bjerre, Anna Kristina; Mørkrid, Lars (Journal article; Peer reviewed, 2023)
      Glomerular filtration rate (GFR) is commonly used in clinical practice for the diagnosis and follow-up of chronic kidney disease. Screening for inborn errors of metabolism (IEM) is based on analysis of biomarkers in urine, ...

    • Repeated bronchoscopy in health and obstructive lung disease: is the airway microbiome stable? 

      Nielsen, Rune; Xue, Yaxin; Jonassen, Inge; Haaland, Ingvild; Kommedal, Øyvind; Wiker, Harald Gotten; Drengenes, Christine; Bakke, Per S.; Eagan, Tomas Mikal Lind (Journal article; Peer reviewed, 2021)
      Objective Little is known concerning the stability of the lower airway microbiome. We have compared the microbiota identified by repeated bronchoscopy in healthy subjects and patients with ostructive lung diseaseases ...

    • Repeated Influenza Vaccination Boosts and Maintains H1N1pdm09 Neuraminidase Antibody Titers 

      Hansen, Lena; Zhou, Fan; Amdam, Håkon; Trieu, Mai Chi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Antibodies to influenza surface protein neuraminidase (NA) have been found to reduce disease severity and may be an independent correlate of protection. Despite this, current influenza vaccines have no regulatory requirements ...

    • Reperfusion Therapy with Low-Dose Insulin or Insulin-Like Growth Factor 2; Myocardial Function and Infarct Size in a Porcine Model of Ischaemia and Reperfusion 

      Salminen, Pirjo-Riitta; Dahle, Geir Olav; Moen, Christian Arvei; Wergeland, Anita; Jonassen, Anne Kristin; Haaverstad, Rune; Matre, Knut; Grong, Ketil (Peer reviewed; Journal article, 2014-05-19)
      In an open-chest porcine model, we examined whether myocardial pharmacological conditioning at the time of reperfusion with low-dose insulin or insulin-like growth factor 2 (IGF2), not affecting serum glucose levels, could ...

    • Repetitive use of levosimendan for treatment of chronic advanced heart failure: Clinical evidence, practical considerations, and perspectives: An expert panel consensus 

      Nieminen, Markku Sakari; Altenberger, Johann; Ben-Gal, Tuvia; Böhmer, Armin; Comin-Colet, Josep; Dickstein, Kenneth; Édes, István Ferenc; Fedele, Francesco; Fonseca, Cândida; García-González, Martín J.; Giannakoulas, Georgios A.; Iakobishvili, Zaza; Jääskeläinen, Pertti; Karavidas, Apostolos I.; Kettner, Jiří; Kivikko, Matti; Lund, Lars H.; Matskeplishvili, Simon T.; Metra, Marco; Morandi, Fabrizio; Oliva, Fabrízio A.; Parkhomenko, Alexander; Parissis, John T.; Pollesello, Piero; Pölzl, Gerhard; Schwinger, Robert H.G.; Segovia, Javier; Seidel, Monika; Vrtovec, Bojan; Wikström, Gerhard (Peer reviewed; Journal article, 2014-06-15)
      Background The intravenous inodilator levosimendan was developed for the treatment of patients with acutely decompensated heart failure. In the last decade scientific and clinical interest has arisen for its repetitive or ...

    • Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study 

      Slieker, Roderick C.; Donnelly, Louise A.; Fitipaldi, Hugo; Bouland, Gerard A.; Giordano, Giuseppe N.; Åkerlund, Mikael; Gerl, Mathias J.; Ahlqvist, Emma; Ali, Ashfaq; Dragan, Iulian; Festa, Andreas; Hansen, Michael K.; Mansour Aly, Dina; Kim, Min; Kuznetsov, Dmitry; Mehl, Florence; Klose, Christian; Simons, Kai; Pavo, Imre; Pullen, Timothy J.; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter; Lyssenko, Valeriya; Legido-Quigley, Cristina; Groop, L; Thorens, Bernard; Franks, Paul W; Ibberson, Mark; Rutter, Guy A.; Beulens, Joline W.J.; ‘t Hart, Leen M.; Pearson, Ewan R. (Journal article; Peer reviewed, 2021)
      Aims/hypothesis: Five clusters based on clinical characteristics have been suggested as diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes. In the current study we replicate and cross-validate these ...

    • Reprogrammed Cells Display Distinct Proteomic SignaturesAssociated with Colony Morphology Variability 

      Bjørlykke, Yngvild; Søviknes, Anne Mette; Hoareau, Laurence; Vethe, Heidrun; Mathisen, Andreas; Chera, Simona; Vaudel, Marc; Ghila, Luiza; Ræder, Helge (Peer reviewed; Journal article, 2019-11-18)
      Human induced pluripotent stem cells (hiPSCs) are of high interest because they can be differentiated into a vast range of different cell types. Ideally, reprogrammed cells should sustain long-term culturing in an ...

    • Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy 

      Ruiz de Garibay, Gorka; García de Jalón, Elvira; Stigen, Endre; Lund, Kjetil B.; Popa, Mihaela-Lucia; Davidson, Ben; Mayoral Safont, Mireia; Rygh, Cecilie Brekke; Espedal, Heidi; Barrett, Torill; Haug, Bengt Erik; McCormack, Emmet (Journal article; Peer reviewed, 2021)
      Nitroreductases (NTR) are a family of bacterial enzymes used in gene directed enzyme prodrug therapy (GDEPT) that selectively activate prodrugs containing aromatic nitro groups to exert cytotoxic effects following gene ...

    • Repurposing chlorpromazine for anti-leukaemic therapy by nanoparticle encapsulation 

      Gundersen, Edvin Tang; Førde, Jan-Lukas; Tislevoll, Benedicte Sjo; Leitch, Calum; Barratt, Gillian; Gjertsen, Bjørn Tore; Herfindal, Lars (Journal article; Peer reviewed, 2022)
      Treatment of acute myeloid leukaemia (AML) relies on decades-old drugs, and while recent years have seen some breakthroughs, AML is still characterised by poor prognosis and survival rate. Drug repurposing can expedite the ...

    • A Research and Development (R&D) roadmap for influenza vaccines: Looking toward the future 

      Moore, Kristine A.; Ostrowsky, Julia T.; Kraigsley, Alison M.; Mehr, Angela J.; Bresee, Joseph S.; Friede, Martin H.; Gellin, Bruce G.; Golding, Josephine P.; Hart, Peter J.; Moen, Ann; Weller, Charlotte L.; Osterholm, Michael T.; Ampofo, William; Barclay, Wendy; Cavaleri, Marco; Cohen, Cheryl; Cowling, Benjamin; Cox, Rebecca Jane; Gust, Ian; Innis, Bruce; Kang, Gagandeep; Katz, Jacqueline M.; Krammer, Florian; Pitisuttithum, Punnee; Post, Diane; Rudenko, Larisa; Siqueira, Marilda M.; Weir, Jerry P. (Journal article; Peer reviewed, 2021)
      Improved influenza vaccines are urgently needed to reduce the burden of seasonal influenza and to ensure a rapid and effective public-health response to future influenza pandemics. The Influenza Vaccines Research and ...

    • Residential greenspace and lung function decline over 20 years in a prospective cohort: The ECRHS study 

      Markevych, Iana; Zhao, Tianyu; Fuertes, Elaine; Marcon, Alessandro; Dadvand, Payam; Vienneau, Danielle; Garcia Aymerich, Judith; Nowak, Dennis; de Hoogh, Kees; Jarvis, Deborah; Abramson, Michael J.; Accordini, Simone; Amaral, Andre FS; Bentouhami, Hayat; Bertelsen, Randi Jacobsen; Boudier, Anne; Bono, Roberto; Bowatte, Gayan; Casas, Lidia; Dharmage, Shyamali C; Forsberg, Bertil; Gislason, Thorarinn; Gnesi, Marco; Holm, Mathias; Jacquemin, Benedicte; Janson, Christer; Jogi, Rain; Johannessen, Ane; Keidel, Dirk; Leynaert, Benedicte; Maldonado Perez, José Antonio; Marchetti, Pierpaolo; Migliore, Enrica; Martínez-Moratalla, Jesús; Orru, Hans; Pin, Isabelle; Potts, James; Probst-Hensch, Nicole; Ranzi, Andrea; Sánchez-Ramos, José Luis; Siroux, Valerie; Soussan, David; Sunyer, Jordi; Urrutia Landa, Isabel; Villani, Simona; Heinrich, Joachim (Journal article; Peer reviewed, 2023)
      Background: The few studies that have examined associations between greenspace and lung function in adulthood have yielded conflicting results and none have examined whether the rate of lung function decline is ...

    • Residential surrounding greenspace and age at menopause: A 20-year European study (ECRHS) 

      Triebner, Kai; Markevych, Iana; Hustad, Simon Steinar; Benediktsdóttir, Bryndís; Forsberg, Bertil; Franklin, Karl A.; Gullón Blanco, José Antonio; Holm, Mathias; Jaquemin, Bénédicte; Jarvis, Debbie; Jõgi, Rain; Leynaert, Bénédicte; Lindberg, Eva; Martínez-Moratalla, Jesús; Muniozguren Agirre, Nerea; Pin, Isabelle; Sánchez-Ramos, José Luis; Heinrich, Joachim; Gomez Real, Francisco; Dadvand, Payam (Peer reviewed; Journal article, 2019-08-19)
      Background Menopause is associated with a number of adverse health effects and its timing has been reported to be influenced by several lifestyle factors. Whether greenspace exposure is associated with age at menopause has ...

    • Residual Corticosteroid Production in Autoimmune Addison Disease 

      Sævik, Åse Bjorvatn; Åkerman, Anna-Karin; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Høybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Valland, Susanna Fonneland; Wahlberg, Jeanette; Holte, Synnøve Emblem; Simunkova, Katerina; Kämpe, Olle; Husebye, Eystein Sverre; Bensing, Sophie; Øksnes, Marianne (Journal article; Peer reviewed, 2020)
      Design: Two-staged, cross-sectional clinical study in 17 centers (Norway, Sweden, and Germany). Residual glucocorticoid (GC) production was defined as quantifiable serum cortisol and 11-deoxycortisol and residual ...

    • Resistance to Chemotherapy in Breast Cancer: Potential role of p21B, p27 and the p53 apoptotic pathway 

      Chrisanthar, Ranjan (Doctoral thesis, 2009-03-13)

    • Resistance to the antiproliferative in vitro effect of PI3K-Akt-mTOR inhibition in primary human acute myeloid leukemia cells is associated with altered cell metabolism 

      Nepstad, Ina; Reikvam, Håkon; Brenner, Annette; Bruserud, Øystein; Hatfield, Kimberley Joanne (Peer reviewed; Journal article, 2018-01-27)
      Constitutive signaling through the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin (PI3K-Akt-mTOR) pathway is present in acute myeloid leukemia (AML) cells. However, AML is a heterogeneous disease, and ...

    • Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? 

      Svanes, Øistein; Skorge, Trude Duelien; Johannessen, Ane; Bertelsen, Randi Jacobsen; Bråtveit, Magne; Forsberg, Bertil; Gislason, Thorarin; Holm, Mathias; Janson, Christer; Jögi, Rain; Macsali, Ferenc; Norbäck, Dan; Omenaas, Ernst; Gomez Real, Francisco; Schlünssen, Vivi; Sigsgaard, Torben; Wieslander, Gunilla; Zock, Jan-Paul; Aasen, Tor Olav Brøvig; Dratva, Julia; Svanes, Cecilie (Journal article; Peer reviewed, 2015)
      Rationale There is some evidence that maternal smoking increases susceptibility to personal smoking’s detrimental effects. One might question whether early life disadvantage might influence susceptibility to occupational ...

    • Respiratory symptoms and cardiovascular causes of deaths: A population-based study with 45 years of follow-up 

      Stavem, Knut; Schirmer, Henrik; Gulsvik, Amund (Journal article; Peer reviewed, 2022)
      This study determined the association between respiratory symptoms and death from cardiovascular (CV) diseases during 45 years in a pooled sample of four cohorts of random samples of the Norwegian population with 95,704 ...