Browsing Department of Clinical Science by Title

Now showing items 2186-2205 of 2310

    • Total Bilirubin Yields Prognostic Information Following a Myocardial Infarction in the Elderly 

      Nilsen, Dennis WT; Myhre, Peder Langeland; Solheim, Svein; Tveit, Sjur Hansen; Kalstad, Are; Laake, Kristian; Tveit, Arnljot; Seljeflot, Ingebjørg (Journal article; Peer reviewed, 2023)
      Total bilirubin consists of an unconjugated form, solubilized by its binding to albumin, and a conjugated form representing a minor part of the circulating bilirubin. As total bilirubin in physiological concentrations is ...

    • Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy 

      Hamfjord, Julian; Guren, Tormod Kyrre; Dajani, Olav; Johansen, Julia Sidenius; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per; Lingjærde, Ole Christian; Tveit, Magne Kjell; Kure, Elin Wenche Hegland; Pallisgaard, Niels; Spindler, Karen-Lise Garm (Peer reviewed; Journal article, 2019-05-02)
      Background: Metastatic colorectal cancer (mCRC) is a heterogeneous disease where prognosis is dependent both on tumor biology and host factors. Total circulating cell-free DNA (cfDNA) has shown to harbor prognostic information ...

    • Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease 

      Eskerud, Ingeborg; Gerdts, Eva; Larsen, Terje Hjalmar; Simon, Judit; Maurovich-Horvat, Pál; Lønnebakken, Mai Tone (Journal article; Peer reviewed, 2021)
      Aim Whether the total coronary atherosclerotic plaque burden is independently associated with myocardial ischemia in non-obstructive coronary artery disease (CAD) is not well established. We aimed to test the association ...

    • Towards stratification of patients with Sjögren’s syndrome : Single cell analyses and immune profiling 

      Sarkar, Irene (Doctoral thesis, 2020-11-06)
      Primary Sjögren’s syndrome (pSS) is a systemic, chronic autoimmune disorder that is characterized by progressive lymphocytic infiltration in the exocrine glands i.e., the salivary and lacrimal glands, leading to immune-mediated ...

    • TP53 status predicts long-term survival in locally advanced breast cancer after primary chemotherapy 

      Eikesdal, Hans Petter; Knappskog, Stian; Aas, Turid; Lønning, Per Eystein (Peer reviewed; Journal article, 2014-10)
      Background: Before the advent of neoadjuvant chemotherapy, radiotherapy and surgery alone were associated with a high risk of uncontrolled locoregional relapses in locally advanced breast cancer (LABC). Material and methods: ...

    • Tracking of lung function from 10 to 35 years after being born extremely preterm or with extremely low birth weight 

      Bårdsen, Tonje; Røksund, Ola Drange; Benestad, Merete; Hufthammer, Karl Ove; Clemm, Hege Synnøve Havstad; Mikalsen, Ingvild Bruun; Øymar, Knut Asbjørn Alexander; Markestad, Trond Jacob; Halvorsen, Thomas; Vollsæter, Maria (Journal article; Peer reviewed, 2022)
      Background Lifelong pulmonary consequences of being born extremely preterm or with extremely low birth weight remain unknown. We aimed to describe lung function trajectories from 10 to 35 years of age for individuals ...

    • Training of medical students in the use of emergency whole blood collection and transfusion in the framework of a civilian walking blood 

      Apelseth, Torunn Oveland; Kristoffersen, Einar Klæboe; Strandenes, Geir; Hervig, Tor Audun (Journal article; Peer reviewed, 2023)
      Introduction: In this report, we describe a training program in emergency whole blood collection and transfusion for medical students at the University of Bergen. The overall aim of the program is to improve the availability ...

    • A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity 

      Bradfield, Jonathan P.; Vogelezang, Suzanne; Felix, Janine F.; Chesi, Alessandra; Helgeland, Øyvind; Horikoshi, Momoko; Karhunen, Ville; Lowry, Estelle; Cousminer, Diana L.; Ahluwalia, Tarunveer S.; Thiering, Elisabeth; Boh, Eileen Tai-Hui; Zafarmand, Mohammad H.; Vilor-Tejedor, Natalia; Wang, Carol A.; Joro, Raimo; Chen, Zhanghua; Gauderman, William J.; Pitkänen, Niina; Parra, Esteban J.; Fernandez-Rhodes, Lindsay; Alyass, Akram; Monnereau, Claire; Curtin, John A.; Have, Christian T.; McCormack, Shana E.; Hollensted, Mette; Frithioff-Bøjsøe, Christine; Valladares-Salgado, Adan; Peralta-Romero, Jesus; Teo, Yik-Ying; Standl, Marie; Leinonen, Jaakko T.; Holm, Jens-Christian; Peters, Triinu; Vioque, Jesus; Vrijheid, Martine; Simpson, Angela; Custovic, Adnan; Vaudel, Marc; Canouil, Mickaël; Lindi, Virpi; Atalay, Mustafa; Kahonen, Mika; Raitakari, Olli T.; van Schaik, Barbera D.C.; Berkowitz, Robert I.; Cole, Shelley A.; Voruganti, V. Saroja; Wang, Yujie; Highland, Heather M.; Comuzzie, Anthony G.; Butte, Nancy F.; Justice, Anne E.; Gahagan, Sheila; Blanco, Estela; Lehtimäki, Terho; Lakka, Timo A.; Hebebrand, Johannes; Bonnefond, Amélie; Grarup, Niels; Froguel, Philippe; Lyytikäinen, Leo-Pekka; Cruz, Miguel; Kobes, Sayuko; Hanson, Robert L.; Zemel, Babette S.; Hinney, Anke; Teo, Koon K.; Meyre, David; North, Kari E.; Gilliland, Frank D.; Bisgaard, Hans; Bustamante, Mariona; Bønnelykke, Klaus; Pennell, Craig E.; Rivadeneira, Fernando; Uitterlinden, André G.; Baier, Leslie J.; Vrijkotte, Tanja G.M.; Heinrich, Joachim; Sørensen, Thorkild I.A.; Saw, Seang-Mei; Pedersen, Oluf; Hansen, Torben; Eriksson, Johan; Widén, Elisabeth; McCarthy, Mark I.; Njølstad, Pål Rasmus; Power, Christine; Hyppönen, Elina; Sebert, Sylvain; Brown, Christopher D.; Järvelin, Marjo-Riitta; Timpson, Nicholas J.; Johansson, Stefan; Hakonarson, Hakon; Jaddoe, Vincent W.V. (Peer reviewed; Journal article, 2019)
      Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted ...

    • Transcapillary fluid balance in children. Methodology and new clinical studies. To the interstitial space - and back again 

      Guthe, Hans Jørgen Timm (Doctoral thesis, 2016-04-29)
      Objective: The capillaries represent a semipermeable barrier between the blood and the interstitium, where there is a continuous exchange of fluid and solutes. Numerous factors affect the tight regulation of this movement ...

    • Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study 

      Guthe, Hans Jørgen Timm; Nedrebø, Torbjørn; Damås, Jan Kristian; Wiig, Helge; Berg, Ansgar (Peer reviewed; Journal article, 2018-02-23)
      Background: Therapeutic hypothermia is neuroprotective in asphyxiated neonates by counteracting mechanisms contributing to brain injury. Although an initial increased permeability is part of an inflammatory reaction and ...

    • Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids 

      Osete, Jordi Requena; Akkouh, Ibrahim Ahmed; Levglevskyi, Oleksandr; Vandenberghe, Matthieu; Reis de Assis, Denis; Ueland, Thor; Kondratskaya, Elena; Holen, Børge; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2023)
      Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a ...

    • Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing 

      Berger, Amund Holte; Bratland, Eirik; Sjøgren, Thea; Heimli, Marte; Tyssedal, Torgeir; Bruserud, Øyvind; Johansson, Stefan; Husebye, Eystein Sverre; Oftedal, Bergithe Eikeland; Wolff, Anette Susanne Bøe (Journal article; Peer reviewed, 2021)
      Autoimmune polyendocrine syndrome type I (APS-1) is a monogenic model disorder of organ-specific autoimmunity caused by mutations in the Autoimmune regulator (AIRE) gene. AIRE facilitates the expression of organ-specific ...

    • Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue's extracellular milieu precede immune responses in Sjögren's syndrome 

      Delaleu, Nicolas Hervé; Nguyen, Cuong Q.; Tekle, Kidane Mebrahtu; Jonsson, Roland; Peck, Ammon B. (Peer reviewed; Journal article, 2013-10-31)
      Introduction: Our understanding of autoimmunity is skewed considerably towards the late stages of overt disease and chronic inflammation. Defining the targeted organ’s role during emergence of autoimmune diseases is, ...

    • Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia 

      Akkouh, Ibrahim; Hughes, Timothy; Steen, Vidar Martin; Glover, Joel; Andreassen, Ole Andreas; Djurovic, Srdjan; Szabo, Attila (Journal article; Peer reviewed, 2021)
      Despite the high heritability of schizophrenia (SCZ), details of its pathophysiology and etiology are still unknown. Recent findings suggest that aberrant inflammatory regulation and microRNAs (miRNAs) are involved. Here ...

    • Transcriptomic landscape of blood platelets in healthy donors 

      Supernat, Anna; Popęda, Marta; Pastuszak, Krzysztof; Best, Myron G.; Grešner, Peter; Veld, Sjors In ’t; Siek, Bartłomiej; Bednarz-Knoll, Natalia; Rondina, Matthew T.; Stokowy, Tomasz; Würdinger, Thomas; Jassem, Jacek; Żaczek, Anna J. (Journal article; Peer reviewed, 2021)
      Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy ...

    • Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1 

      Qu, Heshuang; Heinbäck, Rebecka; Salo, Henna; Ewing, Ewoud; Espinosa, Alexander; Aulin, Cecilia; Harris, Anna Helena Erlandsson (Journal article; Peer reviewed, 2022-06-02)
      Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group ...

    • Transsulfuration metabolites and the association with incident atrial fibrillation – An observational cohort study among Norwegian patients with stable angina pectoris 

      Svenningsson, Mads Malm; Svingen, Gard Frodahl Tveitevåg; Lysne, Vegard; Ueland, Per Magne; Tell, Grethe S.; Pedersen, Eva Ringdal; Dhar, Indu; Nilsen, Dennis W.T.; Nygård, Ottar (Journal article; Peer reviewed, 2020)
      Background/aim Plasma total homocysteine (tHcy) is elevated in patients with persistent vs. paroxysmal atrial fibrillation (AF), and has been related to increased risk of new-onset AF. Homocysteine is degraded to cystathionine ...

    • Treadmill walking with body weight support 

      Aaslund, Mona Kristin (Doctoral thesis, 2012-04-27)
      Background: Rehabilitating walking in patients post-stroke with safe, task-specific, intensive training of sufficient duration, can be challenging. Body weight supported treadmill training (BWSTT) has been proposed as an ...

    • Treatment completion for latent tuberculosis infection in Norway: a prospective cohort study 

      Schein, Yvette Louise; Madebo, Tesfaye; Andersen, Hilde Elise; Arnesen, Trude Margrete; Dyrhol-Riise, Anne Ma; Tveiten, Hallgeir; White, Richard Aubrey; Winje, Brita Askeland (Peer reviewed; Journal article, 2018-11-19)
      Background: Successful treatment of latent tuberculosis infection (LTBI) is essential to reduce tuberculosis (TB) incidence rates in low-burden countries. This study measures treatment completion and determinants of ...

    • Treatment of Exercise-induced Laryngeal Obstruction : Exploring modalities in short and long term 

      Sandnes, Astrid (Doctoral thesis, 2021-05-07)
      Background: Exercise-induced laryngeal obstruction (EILO) is an umbrella term describing inappropriate and transient closure of laryngeal structures during exercise, causing breathlessness and/or noisy respiration (stridor). ...