Browsing Department of Clinical Science by Title

Now showing items 586-605 of 2310

    • DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients 

      Olsen, Maria Belland; Huse, Camilla; Sousa, Mirta; Murphy, Sarah Louise Mikalsen; Sarno, Antonio; Obermann, Tobias Sebastian; Yang, Kuan; Holter, Jan Cato; Jørgensen, Marthe Jøntvedt; Christensen, Erik Egeland; Wang, Wei; Ji, Ping; Heggelund, Lars; Hoel, Hedda; Dyrhol-Riise, Anne Ma; Gregersen, Ida; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente; Dahl, Tuva Børresdatter (Journal article; Peer reviewed, 2022)
      Purpose: Reactive oxygen species (ROS) are an important part of the inflammatory response during infection but can also promote DNA damage. Due to the sustained inflammation in severe Covid-19, we hypothesized that ...

    • DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells 

      Jacobsen, Rhian Gaenor; Gavgani, Fatemeh Mazloumi; Mellgren, Gunnar; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2016-07-09)
      DNA topoisomerases (Topo) are multifunctional enzymes resolving DNA topological problems such as those arising during DNA replication, transcription and mitosis. Mammalian cells express 2 class II isoforms, Topoisomerases ...

    • A DNA vaccine that targets hemagglutinin to antigen-presenting cells protects mice against H7 influenza 

      Andersen, Tor Kristian; Zhou, Fan; Cox, Rebecca Jane; Bogen, Bjarne; Grødeland, Gunnveig (Peer reviewed; Journal article, 2017-12)
      Zoonotic influenza H7 viral infections have a case fatality rate of about 40%. Currently, no or limited human to human spread has occurred, but we may be facing a severe pandemic threat if the virus acquires the ability ...

    • DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease 

      Lee, Jin H.; McDonald, Merry-Lynn N.; Cho, Michael H.; Wan, Emily S.; Castaldi, Peter J.; Hunninghake, Gary M.; Marchetti, Nathaniel; Lynch, David A.; Crapo, James D.; Lomas, David A.; Coxson, Harvey O.; Bakke, Per; Silverman, Edwin K.; Hersh, Craig P. (Peer reviewed; Journal article, 2014-08-20)
      Background: Chronic obstructive pulmonary disease (COPD) is characterized by expiratory flow limitation, causing air trapping and lung hyperinflation. Hyperinflation leads to reduced exercise tolerance and poor quality of ...

    • Do differences in diagnostic criteria for late fetal growth restriction matter? 

      Mylrea-Foley, Bronacha; Napolitano, Raffaele; Gordijn, Sanne; Wolf, Hans; Lees, Christoph C.; Stampalija, Tamara; Arabin, B.; Berger, A.; Bergman, E.; Bhide, A; Bilardo, C.M.; Breeze, A.C.; Brodszki, J.; Calda, P.; Cesari, E.; Cetin, I.; Derks, J.; Ebbing, Cathrine; Ferrazzi, E.; Frusca, T.; Ganzevoort, W.; Gyselaers, W.; Hecher, K.; Klaritsch, P.; Krofta, L.; Lindgren, P.; Lobmaier, S.M.; Marlow, N.; Maruotti, G.M.; Mecacci, F.; Myklestad, Kirsti; Prefumo, F.; Raio, L.; Richter, J.; Sande, Ragnar; Valensise, H.; Visser, G.H.A.; Wee, L. (Journal article; Peer reviewed, 2023)
      BACKGROUND Criteria for diagnosis of fetal growth restriction differ widely according to national and international guidelines, and further heterogeneity arises from the use of different biometric and Doppler reference ...

    • Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood? 

      Jami, Eshim S.; Hammerschlag, Anke R.; Sallis, Hannah M.; Qiao, Zhen; Andreassen, Ole A.; Magnus, Per Minor; Njølstad, Pål Rasmus; Havdahl, Alexandra; Pingault, Jean-Baptiste; Evans, David M.; Munafò, Marcus R.; Ystrom, Eivind; Bartels, Meike; Middeldorp, Christel (Journal article; Peer reviewed, 2023)
      Parental genes may indirectly influence offspring psychiatric outcomes through the environment that parents create for their children. These indirect genetic effects, also known as genetic nurture, could explain individual ...

    • Do reduced numbers of plasmacytoid dendritic cells contribute to the aggressive clinical course of COVID-19 in chronic lymphocytic leukaemia? 

      Smith, Carl Inge Edvard; Zain, Rula; Österborg, Anders; Palma, Marzia; Buggert, Marcus; Bergman, Peter; Bryceson, Yenan (Journal article; Peer reviewed, 2022)
      Infections with SARS-CoV-2 have been unduly severe in patients with haematological malignancies, in particular in those with chronic lymphocytic leukaemia (CLL). Based on a series of observations, we propose that an ...

    • Does a history of migraine affect the rate of thrombolysis in young stroke patients? 

      Øygarden, Halvor; Kvistad, Christopher Elnan; Thomassen, Lars; Waje-Andreassen, Ulrike; Næss, Halvor (Peer reviewed; Journal article, 2013)
      Background. Migraine is prevalent in young patients and a frequent stroke mimic. To distinguish stroke mimics from true stroke can be difficult, and there is a possibility of misdiagnosing a stroke as a migrainous attack ...

    • Does Current Diabetes Technology Improve Metabolic Control? A Cross-Sectional Study on the Use of Insulin Pumps and Continuous Glucose Monitoring Devices in a Nationwide Pediatric Population 

      Bratke, Heiko; Margeirsdottir, Hanna D.; Assmus, Jörg; Njølstad, Pål Rasmus; Skrivarhaug, Torild (Journal article; Peer reviewed, 2021)
      Objective To examine the use of multiple daily injections (MDI), insulin pumps, self-measured blood glucose (SMBG), and continuous glucose monitoring (CGM) systems, and their association with glycated hemoglobin (HbA1c), ...

    • Does sarcopenia predict change in mobility after hip fracture? A multicenter observational study with one-year follow-up 

      Steihaug, Ole Martin; Ranhoff, Anette Hylen; Gjesdal, Clara Gram; Bogen, Bård Erik; Lien, Gunhild; Kristoffersen, Målfrid Holen; Hufthammer, Karl Ove (Peer reviewed; Journal article, 2018-03-05)
      Background: Patients with hip fracture frequently have sarcopenia and are at great risk of loss of mobility. We have investigated if sarcopenia predicts change in mobility after hip fracture. Methods: This is a prospective, ...

    • Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes 

      Oftedal, Bergithe Eikeland; Assing, Kristian; Baris, Safa; Safgren, Stephanie L.; Johansen, Isik S.; Jakobsen, Marianne Antonius; Babovic-Vuksanovic, Dusica; Agre, Katherine; Klee, Eric W.; Majcic, Emina; Ferré, Elise M.N.; Schmitt, Monica M.; DiMaggio, Tom; Rosen, Lindsey B.; Rahman, Muhammad; Chrysis, Dionisios; Giannakopoulos, Aristeidis; Garcia, Maria Tallon; González-Granado, Luis Ignacio; Stanley, Katherine; Galant-Swafford, Jessica; Suwannarat, Pim; Meyts, Isabelle; Lionakis, Michail S.; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2023)
      Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive disease characterized by severe and childhood onset organ-specific autoimmunity caused by mutations in the autoimmune regulator (AIRE) gene. More ...

    • Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort 

      Krull, Florian; Akkouh, Ibrahim Ahmed; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean; Brattbakk, Hans-Richard; Steen, Vidar Martin; Steen, Nils Eiel; Djurovic, Srdjan; Andreassen, Ole (Journal article; Peer reviewed, 2022)
      Lithium is the first-line treatment for bipolar disorder (BD), but there is a large variation in response rate and adverse effects. Although the molecular effects of lithium have been studied extensively, the specific ...

    • Double paternal uniparental isodisomy 7 and 15 presenting with Beckwith–Wiedemann spectrum features 

      Berland, Siren; Rustad, Cecilie; Bentsen, Mariann; Wollen, Embjørg Julianne; Turowski, Gitta Erika; Johansson, Stefan; Houge, Gunnar Douzgos; Haukanes, Bjørn Ivar (Journal article; Peer reviewed, 2021)
      Here we describe for the first time double paternal uniparental isodisomy (iUPD) 7 and 15 in a baby boy with features in the Beckwith–Wiedemann syndrome spectrum (BWSp) (placentomegaly, hyperinsulinism, enlarged viscera, ...

    • Double-vs single-balloon catheter for induction of labor: Systematic review and individual participant data meta-analysis 

      Peel, Morgan D.; Croll, Doortje M. R.; Kessler, Jørg; Haugland, Birte; Pennell, Craig E.; Dickinson, Jan E.; Salim, Raed; Zafran, Noah; Palmer, Kirsten R.; Mol, Ben W.; Li, Wentao (Journal article; Peer reviewed, 2023)
      Introduction Evidence comparing double-balloon vs single-balloon catheter for induction of labor is divided. We aim to compare the efficacy and safety of double-vs single-balloon catheters using individual participant ...

    • Drug adherence in patient group with Parkinson's disease 

      Flagstad, Kine Sola (Master thesis, 2018-06-29)
      Background Patients with Parkinson’s disease needs medicines administered frequently to manage their condition and maintain their quality of life. Poor medicine adherence may influence health negatively, and cause an ...

    • Drug delivery in pancreatic cancer : Quantitative studies of gemcitabine and sonoporation in patients and cell line models 

      Bjånes, Tormod Karlsen (Doctoral thesis, 2020-03-06)
      Background Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to late stage diagnosis and unresponsiveness to chemotherapies. A dense desmoplastic tumour stroma is considered to represent a barrier against ...

    • Drug information in pregnancy. Attitudes and needs among pregnant women and physicians 

      Widnes, Sofia Frost (Doctoral thesis, 2013-10-25)
      Background: Drug use in pregnancy is common and both pregnant women and their physicians are in need of appropriate information for decision-making regarding drug therapy. However, uncertainty about the risks of drug use ...

    • Durable immune responses after BNT162b2 vaccination in home-dwelling old adults 

      Hansen, Lena; Brokstad, Karl Albert; Bansal, Amit; Zhou, Fan; Bredholt, Geir; Onyango, Therese Bredholt; Sandnes, Helene Heitmann; Elyanow, Rebecca; Madsen, Anders; Trieu, Mai Chi; Sævik, Marianne; Søyland, Hanne; Olofsson, Jan Stefan; Vahokoski, Juha; Ertesvåg, Nina Urke; Fjelltveit, Elisabeth Berg; Shafiani, Shahin; Tøndel, Camilla; Chapman, Heidi; Kaplan, Ian; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection ...

    • Duration of elevated heart rate Is an important predictor of exercise-induced troponin elevation 

      Bjørkavoll-Bergseth, Magnus; Kleiven, Øyunn; Auestad, Bjørn Henrik; Eftestøl, Trygve Christian; Oskal, Kay Raymond; Nygård, Martin; Skadberg, Øyvind; Aakre, Kristin Moberg; Melberg, Tor Harald; Gjesdal, Knut; Ørn, Stein (Journal article; Peer reviewed, 2020)
      Background The precise mechanisms causing cardiac troponin (cTn) increase after exercise remain to be determined. The aim of this study was to investigate the impact of heart rate (HR) on exercise‐induced cTn increase by ...

    • Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls 

      van der Does, Anne M; Heijink, Marieke; Mayboroda, Oleg A.; Persson, Louise Jeanette Pauline; Aanerud, Marianne; Bakke, Per S.; Eagan, Tomas Mikal; Hiemstra, Pieter S.; Giera, Martin (Peer reviewed; Journal article, 2019)
      Introduction: Disturbances in onset and resolution of inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. Dietary polyunsaturated fatty acids (PUFAs) can be converted into lipid mediators ...