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Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer
(Journal article; Peer reviewed, 2022)Background: Immune checkpoint blockade (ICB) results in radiologic tumour response dynamics that differ from chemotherapy efficacy measures and require an early signal of clinical utility. Methods: Previously untreated, ... -
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
(Journal article; Peer reviewed, 2023)Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a ... -
Early Response in Cellulitis: A Prospective Study of Dynamics and Predictors
(Peer reviewed; Journal article, 2016)Background: Skin and soft tissue infections are common reasons for medical care. Use of broad-spectrum therapy and costs have increased. Assessment of early treatment response has been given a central role both in clinical ... -
Early surfactant and non-invasive ventilation versus intubation and surfactant: a propensity score-matched national study
(Journal article; Peer reviewed, 2022)Objective: To compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks. Setting: All neonatal intensive ... -
Early vascular aging in young and middle-aged ischemic stroke patients: The Norwegian stroke in the young study
(Peer reviewed; Journal article, 2014-11-18)Background: Ischemic stroke survivors have high risk of cardiovascular morbidity and mortality even at young age, suggesting that early arterial aging is common among such patients. Methods: We measured aortic stiffness ... -
Early-Onset Sepsis in Neonates - A Population-Based Study in South-West Norway From 1996 to 2018
(Journal article; Peer reviewed, 2021)Background: The epidemiology of early-onset sepsis (EOS) may change over time. Longitudinal surveillance of causative pathogens, antibiotic susceptibility patterns and antibiotic therapy is important for optimal therapy ... -
The effect of antibiotic stewardship interventions with stakeholder involvement in hospital settings: A multicentre, cluster randomized controlled intervention study
(Peer reviewed; Journal article, 2018-09-10)Background: There is limited evidence from multicenter, randomized controlled studies to inform planning and implementation of antibiotic stewardship interventions in hospitals. Methods: A cluster randomized, controlled, ... -
The Effect of Biological Treatment on Fatigue in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
(Journal article; Peer reviewed, 2023)Background: Fatigue is a frequent complaint in patients with inflammatory bowel disease. Biological drugs have demonstrated beneficial effects on some extraintestinal manifestations, but the effect on fatigue is not ... -
The effect of drug-eluting stents on target lesion revascularization in native coronary arteries: results from the NORSTENT randomized study
(Journal article; Peer reviewed, 2020)Background: The NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention (PCI) with a drug-eluting stent (DES) or bare-metal stent (BMS) with 5-year follow-up. No difference was found in the composite ... -
The effect of electroconvulsive therapy (ECT) on serum kynurenine pathway metabolites in late-life depression
(Journal article; Peer reviewed, 2023)Background: Depression is reportedly associated with alterations in kynurenine pathway metabolites (kynurenines). Several kynurenines are involved in glutamate signaling, and some have potentially neurotoxic effects while ... -
Effect of Folic Acid Supplementation on Levels of Circulating Monocyte Chemoattractant Protein-1 and the Presence of Intravascular Ultrasound Derived Virtual Histology Thin-Cap Fibroatheromas in Patients with Stable Angina Pectoris
(Peer reviewed; Journal article, 2013-07-25)Background: Virtual Histology Intravascular Ultrasound (VH–IVUS) may be used to detect early signs of unstable coronary artery disease. Monocyte Chemoattractant Protein-1 (MCP-1) is linked with coronary atherosclerosis and ... -
Effect of genetic variability in 20 pharmacogenes on concentrations of tamoxifen and its metabolites
(Journal article; Peer reviewed, 2021)Background: Tamoxifen, as a treatment of estrogen receptor positive (ER+) breast cancer, is a weak anti-estrogen that requires metabolic activation to form metabolites with higher anti-estrogenic activity. Endoxifen is the ... -
The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults
(Peer reviewed; Journal article, 2018-05-11)The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial ... -
The effect of low dose marine protein hydrolysates on short-term recovery after high intensity performance cycling: A double-blinded crossover study
(Peer reviewed; Journal article, 2019)Background: Knowledge of the effect of marine protein hydrolysate (MPH) supplementation to promote recovery after high intensity performance training is scarce. The aim of this study was to examine the effect of MPH ... -
Effect of maternal sleep on embryonic development
(Journal article; Peer reviewed, 2022)The concept of developmental origin of health and disease has ignited a search for mechanisms and health factors influencing normal intrauterine development. Sleep is a basic health factor with substantial individual ... -
Effect of Non-tuberculous Mycobacteria on Host Biomarkers Potentially Relevant for Tuberculosis Management.
(Peer reviewed; Journal article, 2014-10-16)Background Non-tuberculous mycobacteria (NTM) are different from Mycobacterium tuberculosis (MTB) both in their ubiquitous environmental distribution and in their reduced capacity to cause disease. While often neglected ... -
The Effect of Protease-Activated Receptor-1 (PAR-1) Inhibition on Endothelial-Related Biomarkers in Patients with Coronary Artery Disease
(Journal article; Peer reviewed, 2022)Background: Vorapaxar has been shown to reduce cardiovascular mortality in postmyocardial infarction (MI) patients. Pharmacodynamic biomarker research related to protease-activated receptor-1 (PAR-1) inhibition with vorapaxar ... -
Effect of Temporal and Spatial Smoothing on Speckle–Tracking‑Derived Strain in Neonates
(Journal article; Peer reviewed, 2021)Clinical application of strain in neonates requires an understanding of which image acquisition and processing parameters affect strain values. Previous studies have examined frame rate, transmitting frequency, and vendor ... -
Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers
(Peer reviewed; Journal article, 2012-10-05)Background: While BRCA mutation carriers possess a 20-40% lifetime risk of developing ovarian cancer, knowledge about genetic modifying factors influencing the phenotypic expression remains obscure. We explored the ...