Browsing Department of Clinical Science by Title
Now showing items 2241-2260 of 2374
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TNF-α is associated with loss of lean body mass only in already cachectic COPD patients
(Peer reviewed; Journal article, 2012-06-18) -
Toll-like Receptor 4, Osteoblasts and Leukemogenesis; the Lesson from Acute Myeloid Leukemia
(Journal article; Peer reviewed, 2022-01-23)Toll-like receptor 4 (TLR4) is a pattern-recognizing receptor that can bind exogenous and endogenous ligands. It is expressed by acute myeloid leukemia (AML) cells, several bone marrow stromal cells, and nonleukemic cells ... -
Toluene diisocyanate (TDI)-induced asthma: Inflammatory and immunological responses to TDI, ovalbumin (OVA) and ovalbumin peptide OVA 323-339 in mouse models
(Doctoral thesis, 2012-06-07)Among three major diisocyanates: TDI, methylenediphenyl diisocyanate (MDI) and hexamethylene diisocyanate (HDI), TDI has been regarded as the leading cause of diisocyanate-induced asthma. The principal feature of TDI-induced ... -
A toolbox of machine learning software to support microbiome analysis
(Journal article; Peer reviewed, 2023)The human microbiome has become an area of intense research due to its potential impact on human health. However, the analysis and interpretation of this data have proven to be challenging due to its complexity and high ... -
Total Bilirubin Yields Prognostic Information Following a Myocardial Infarction in the Elderly
(Journal article; Peer reviewed, 2023)Total bilirubin consists of an unconjugated form, solubilized by its binding to albumin, and a conjugated form representing a minor part of the circulating bilirubin. As total bilirubin in physiological concentrations is ... -
Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy
(Peer reviewed; Journal article, 2019-05-02)Background: Metastatic colorectal cancer (mCRC) is a heterogeneous disease where prognosis is dependent both on tumor biology and host factors. Total circulating cell-free DNA (cfDNA) has shown to harbor prognostic information ... -
Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease
(Journal article; Peer reviewed, 2021)Aim Whether the total coronary atherosclerotic plaque burden is independently associated with myocardial ischemia in non-obstructive coronary artery disease (CAD) is not well established. We aimed to test the association ... -
Towards stratification of patients with Sjögren’s syndrome : Single cell analyses and immune profiling
(Doctoral thesis, 2020-11-06)Primary Sjögren’s syndrome (pSS) is a systemic, chronic autoimmune disorder that is characterized by progressive lymphocytic infiltration in the exocrine glands i.e., the salivary and lacrimal glands, leading to immune-mediated ... -
TP53 status predicts long-term survival in locally advanced breast cancer after primary chemotherapy
(Peer reviewed; Journal article, 2014-10)Background: Before the advent of neoadjuvant chemotherapy, radiotherapy and surgery alone were associated with a high risk of uncontrolled locoregional relapses in locally advanced breast cancer (LABC). Material and methods: ... -
Tracking of lung function from 10 to 35 years after being born extremely preterm or with extremely low birth weight
(Journal article; Peer reviewed, 2022)Background Lifelong pulmonary consequences of being born extremely preterm or with extremely low birth weight remain unknown. We aimed to describe lung function trajectories from 10 to 35 years of age for individuals ... -
Training of medical students in the use of emergency whole blood collection and transfusion in the framework of a civilian walking blood
(Journal article; Peer reviewed, 2023)Introduction: In this report, we describe a training program in emergency whole blood collection and transfusion for medical students at the University of Bergen. The overall aim of the program is to improve the availability ... -
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity
(Peer reviewed; Journal article, 2019)Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted ... -
Transcapillary fluid balance in children. Methodology and new clinical studies. To the interstitial space - and back again
(Doctoral thesis, 2016-04-29)Objective: The capillaries represent a semipermeable barrier between the blood and the interstitium, where there is a continuous exchange of fluid and solutes. Numerous factors affect the tight regulation of this movement ... -
Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study
(Peer reviewed; Journal article, 2018-02-23)Background: Therapeutic hypothermia is neuroprotective in asphyxiated neonates by counteracting mechanisms contributing to brain injury. Although an initial increased permeability is part of an inflammatory reaction and ... -
Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
(Journal article; Peer reviewed, 2023)Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a ... -
Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing
(Journal article; Peer reviewed, 2021)Autoimmune polyendocrine syndrome type I (APS-1) is a monogenic model disorder of organ-specific autoimmunity caused by mutations in the Autoimmune regulator (AIRE) gene. AIRE facilitates the expression of organ-specific ... -
Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue's extracellular milieu precede immune responses in Sjögren's syndrome
(Peer reviewed; Journal article, 2013-10-31)Introduction: Our understanding of autoimmunity is skewed considerably towards the late stages of overt disease and chronic inflammation. Defining the targeted organ’s role during emergence of autoimmune diseases is, ... -
Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia
(Journal article; Peer reviewed, 2021)Despite the high heritability of schizophrenia (SCZ), details of its pathophysiology and etiology are still unknown. Recent findings suggest that aberrant inflammatory regulation and microRNAs (miRNAs) are involved. Here ... -
Transcriptomic landscape of blood platelets in healthy donors
(Journal article; Peer reviewed, 2021)Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy ... -
Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1
(Journal article; Peer reviewed, 2022-06-02)Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group ...