Browsing Department of Clinical Science by Title
Now showing items 827-846 of 2318
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Function and regulation of Steroid Receptor Coactivator 2. Transcriptional regulation of cellular metabolism
(Doctoral thesis, 2015-12-18)Nuclear hormone receptors (NRs) associate with coregulators to enable complex programs of gene expression. The p160 steroid receptor coactivator 2 (SRC- 2/GRIP1) regulates metabolism and cellular processes in a tissue-specific ... -
Functional analyses of BRCA1 variants of unknown significance found in hereditary breast or ovarian cancer families in Norway: A tool for improved diagnosis
(Doctoral thesis, 2023-03-21)Tumorsuppressorgenet BRCA1 speler mange viktige roller for å hindre tumorutvikling, og endringar i BRCA1-genet er ei av hovudårsakene til arveleg bryst- og eggstokk-kreft (HBOC). I artikkel I vart det laga ei oversikt over ... -
Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions
(Journal article; Peer reviewed, 2023-01-19)The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). ... -
Functional analysis of tilS homologues in Bacteria and Archaea
(Master thesis, 2005-09-09)Out of all of the microorganisms sequenced so far about one third of the genes have unknown function. Several studies have shown that information on evolutionary relationships between unknown genes can aid in the prediction ... -
Functional and Binding H1N1pdm09-Specific Antibody Responses in Occasionally and Repeatedly Vaccinated Healthcare Workers: A Five-Year Study (2009-2014)
(Journal article; Peer reviewed, 2021)Background: In 2009, a novel influenza A/H1N1pdm09 emerged and caused a pandemic. This strain continued to circulate and was therefore included in the seasonal vaccines up to the 2016/2017-season. This provided a unique ... -
Functional characterization of genetic risk factors in autoimmune Addison’s disease
(Doctoral thesis, 2020-10-23)Autoimmune diseases occur when the immune system attacks and damages the body’s own tissue. Why people develop these diseases, and how the autoimmune reaction develops are unanswered questions. Autoimmune Addison's disease ... -
Functional studies of novel CYP21A2 mutations detected in Norwegian patients with congenital adrenal hyperplasia
(Peer reviewed; Journal article, 2014)In about 95% of cases, congenital adrenal hyperplasia (CAH) is caused by mutations in CYP21A2 gene encoding steroid 21-hydroxylase (21OH). Recently, we have reported four novel CYP21A2 variants in the Norwegian population ... -
Functional toll-like receptors (TLRs) are expressed by a majority of primary human acute myeloid leukemia cells and inducibility of the TLR signaling pathway is associatedwith a more favorable phenotype
(Peer reviewed; Journal article, 2019-07-11)Acute myeloid leukemia (AML) is a highlyheterogeneous disease withregardto biological characteristics and receptor expression. Toll-like receptors (TLRs) are upstream to the transcription factor NFκB and part of the innate ... -
Fysisk aktivitet og astma blant barn og ungdommer i Bergen – RHINESSA-studien
(Master thesis, 2020-06-19)En stor andel av barn og unge i Norge har den kroniske lungesykdommen astma og behandles med astmamedikamenter for dette. Samtidig viser rapporten «Kartlegging av fysisk aktivitet, sedat tid og fysisk form blant barn og ... -
Gamma Knife Radiosurgery does not alter the copy number aberration profile in sporadic vestibular schwannoma
(Journal article; Peer reviewed, 2020)Introduction: Ionizing radiation is a known etiologic factor in tumorigenesis and its role in inducing malignancy in the treatment of vestibular schwannoma has been debated. The purpose of this study was to identify a copy ... -
Gastrointestinal colonization of extended-spectrum beta-lactamase-producing bacteria among children below five years of age hospitalized with fever in Dar es Salaam, Tanzania
(Journal article; Peer reviewed, 2022)Objectives: Gastrointestinal colonization of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) is of concern because prior colonization increases risk for subsequent infections. To date, the link between ... -
Gel2DE - A software tool for correlation analysis of 2D gel electrophoresis data
(Peer reviewed; Journal article, 2013-07-06)Background: Two-dimensional gel electrophoresis (2DE) is a powerful technique for studying protein isoforms and their modifications. Existing commercial 2D image analysis tools rely on spot detection that limits analysis ... -
Gender differences in childhood lyme neuroborreliosis
(Peer reviewed; Journal article, 2015-10-04)Background. Many neurological diseases show differences between genders. We studied gender differences in childhood Lyme neuroborreliosis (LNB) in an endemic area of Lyme borreliosis in Norway. Methods. In a population ... -
Gender-related differences in cardiometabolic risk factors and lifestyle behaviors in treatment-seeking adolescents with severe obesity
(Peer reviewed; Journal article, 2018-02-14)Background: Obesity during adolescence is associated with cardiovascular mortality in adulthood. The adverse obesity-related cardiometabolic risk profile is already observed in adolescence. We aimed to examine possible ... -
Gene expression response in peripheral blood cells of petroleum workers exposed to sub-ppm benzene levels
(Peer reviewed; Journal article, 2018-10-27)Altered gene expression in pathways relevant to leukaemogenesis, as well as reduced levels of circulating lymphocytes, have been reported in workers that were exposed to benzene concentrations below 1 ppm. In this study, ... -
Gene Methylation and Silencing of WIF1 Is a Frequent Genetic Abnormality in Mantle Cell Lymphoma
(Journal article; Peer reviewed, 2021)We have previously shown that the Wnt canonical pathway (WCP) is constitutively active in most cases of mantle cell lymphoma (MCL). Here, we aimed to elucidate the mechanisms underlying this biochemical deregulation. We ... -
A gene signature identifying CIN3 regression and cervical cancer survival
(Journal article; Peer reviewed, 2021-11-16)The purpose of this study was to establish a gene signature that may predict CIN3 regression and that may aid in selecting patients who may safely refrain from conization. Oncomine mRNA data including 398 immune-related ... -
Generating a Precision Endoxifen Prediction Algorithm to Advance Personalized Tamoxifen Treatment in Patients with Breast Cancer
(Journal article; Peer reviewed, 2021)Tamoxifen is an endocrine treatment for hormone receptor positive breast cancer. The effectiveness of tamoxifen may be compromised in patients with metabolic resistance, who have insufficient metabolic generation of the ... -
Genetic alterations associated with malignant transformation of sporadic vestibular schwannoma
(Journal article; Peer reviewed, 2022)Introduction: Malignant peripheral nerve sheath tumor of the vestibulocochlear nerve (VN-MPNST) is exceedingly rare and carries a poor prognosis. Little is known about its underlying genetics and in particular the process ... -
Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome
(Journal article; Peer reviewed, 2020)Objectives Clinical presentation of primary Sjögren’s syndrome (pSS) varies considerably. A shortage of evidence-based objective markers hinders efficient drug development and most clinical trials have failed to reach ...