Blar i Department of Clinical Science på tittel

Viser treff 1706-1725 av 2318

    • Polymorphisms in the TP53-MDM2-MDM4-axis in patients with rheumatoid arthritis 

      Gansmo, Liv Beathe; Lie, Benedicte Alexandra; Mæhlen, Marthe Thoresen; Vatten, Lars Johan; Romundstad, Pål Richard; Hveem, Kristian; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2021)
      Background In addition to being a tumour suppressor, TP53 is a suppressor of inflammation, and dysfunction of this gene has been related to autoimmune diseases. Patients with autoimmunity, such as rheumatoid arthritis ...

    • Poor outcome in hypoxic endometrial carcinoma is related to vascular density 

      Reijnen, Casper; van Weelden, Willem Jan; Arts, Martijn S.J.P.; Peters, Johan P.; Rijken, Paul F.; van de Vijver, Koen; Santacana, Maria; Bronsert, Peter; Bulten, Johan; Hirschfeld, Marc; Colas, Eva; Gil-Moreno, Antonio; Reques, Armando; Mancebo, Gemma; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Minar, Lubos; Jandakova, Eva; Snijders, Marc P.L.M.; van den Berg-van Erp, Saskia; Küsters-Vandevelde, Heidi V.N.; Matias-Guiu, Xavier; Amant, Frederic; Massuger, Leon F.A.G.; Bussink, Johan; Pijnenborg, Johanna M.A. (Peer reviewed; Journal article, 2019-04-23)
      Background Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. Methods Tumour slides ...

    • A population based validation study of self-reported pensions and benefits: the Nord-Trøndelag health study (HUNT) 

      Myrtveit, Solbjørg Makalani; Steinsland Ariansen, Anja Maria; Wilhelmsen, Ingvard; Krokstad, Steinar; Mykletun, Arnstein (Peer reviewed; Journal article, 2013-01-23)
      Background: Measures of disability pensions, sickness certification and long-term health related benefits are often self-reported in epidemiological studies. Few studies have examined these measures, and the validity is ...

    • Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649) 

      Knappskog, Stian; Gansmo, Liv Beathe; Dibirova, Khadizha; Metspalu, Andres; Cybulski, Cezary; Peterlongo, Paolo; Aaltonen, Lauri; Vatten, Lars Johan; Romundstad, Pål Richard; Hveem, Kristian; Devilee, Peter; Evans, Gareth D; Lin, Dongxin; Van Camp, Guy; Manolopoulos, Vangelis G; Osorio, Ana; Milani, Lili; Ozcelik, Tayfun; Zalloua, Pierre; Mouzaya, Francis; Bliznetz, Elena; Balanovska, Elena; Pocheshkova, Elvira; Kucinskas, Vaidutis; Atramentova, Lubov; Nymadawa, Pagbajabyn; Titov, Konstantin; Lavryashina, Maria; Yusupov, Yuldash; Bogdanova, Natalia; Koshel, Sergey; Zamora, Jorge; Wedge, David C.; Charlesworth, Deborah; Dörk, Thilo; Balanovsky, Oleg; Lønning, Per Eystein (Peer reviewed; Journal article, 2014-04-18)
      The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and ...

    • Population pharmacokinetics of tacrolimus in kidney transplant recipients - A model for individual dosing 

      Størset, Elisabet (Master thesis, 2012-11-01)
      Background: Population pharmacokinetics is the study of pharmacokinetic variability in the population. One goal of such studies is to improve individual drug treatment by identifying relationships between pharmacokinetic ...

    • Population prevalence and inheritance pattern of recurrent CNVs associated with neurodevelopmental disorders in 12,252 newborns and their parents 

      Smajlagic, Dinka; Lavrichenko, Ksenia; Berland, Siren; Helgeland, Øyvind; Knudsen, Gun Peggy Strømstad; Vaudel, Marc; Haavik, Jan; Knappskog, Per; Njølstad, Pål Rasmus; Houge, Gunnar; Johansson, Stefan (Journal article; Peer reviewed, 2020)
      Recurrent copy number variations (CNVs) are common causes of neurodevelopmental disorders (NDDs) and associated with a range of psychiatric traits. These CNVs occur at defined genomic regions that are particularly prone ...

    • A positive association between nutritional risk and the incidence of surgical site infections: A hospital-based register study 

      Skeie, Eli; Koch, Anne Mette; Harthug, Stig; Fosse, Unni; Sygnestveit, Kari; Nilsen, Roy Miodini; Tangvik, Randi Julie (Peer reviewed; Journal article, 2018-05-15)
      Surgical site infections (SSI) are amongst the most common health care-associated infections and have adverse effects for patient health and for hospital resources. Although surgery guidelines recognize poor nutritional ...

    • The possible importance of β3 integrins for leukemogenesis and chemoresistance in acute myeloid leukemia 

      Johansen, Silje; Brenner, Annette; Bartaula-Brevik, Sushma; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2018-01-15)
      Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy where the immature leukemia cells communicate with neighboring cells through constitutive cytokine release and through their cell surface adhesion ...

    • Possible interactions between EGFR vIII mediated regulation of proliferation and metabolism in glioma cells 

      Solhaug, Gisle Størseth (Master thesis, 2009-05-20)
      The life cycle of a normal cell is strictly controlled by multiple check points and regulatory factors. Cancer cells on the other hand contain defects in the regulatory machinery that govern cell proliferation and homeostasis, ...

    • Post COVID-19 condition after delta infection and omicron reinfection in children and adolescents 

      Ertesvåg, Nina Urke; Iversen, Arild; Blomberg, Bjørn; Özgümüs, Türküler; Rijal, Pramila; Fjelltveit, Elisabeth Berg; Cox, Rebecca Jane; Langeland, Nina; Haug, Kjell; Sandnes, Helene Heitmann; Mohn, Kristin Greve-Isdahl; Olofsson, Jan Stefan; Sævik, Marianne; Brokstad, Christopher James; Kuwelker, Kanika; Heienberg, Kristin (Journal article; Peer reviewed, 2023)
      Background: The burden of COVID-19 in children and adolescents has increased during the delta and omicron waves, necessitating studies of long-term symptoms such as fatigue, dyspnoea and cognitive problems. Furthermore, ...

    • Post-giardiasis functional gastrointestinal disorders and chronic fatigue syndrome – clinical symptoms, inflammation and immune responses 

      Hanevik, Kurt (Doctoral thesis, 2012-01-20)

    • Postpartum hemorrhage in families : A Norwegian population-based study 

      Linde, Lorentz Erland (Doctoral thesis, 2022-10-27)
      Bakgrunn: Postpartum blødning (PPB) er den ledende direkte årsaken til verdens mødredødelighet og forekomsten har en økende trend i utviklende land. Mål: Å studere gjentagelsesrisiko for PPB hos en kvinne, over generasjoner ...

    • A Potential Golden Age to Come-Current Tools, Recent Use Cases, and Future Avenues for De Novo Sequencing in Proteomics 

      Muth, Thilo; Hartkopf, Felix; Vaudel, Marc; Renard, Bernhard Y (Peer reviewed; Journal article, 2018-07-02)
      In shotgun proteomics, peptide and protein identification is most commonly conducted using database search engines, the method of choice when reference protein sequences are available. Despite its widespread use the ...

    • Potential Transcriptional Biomarkers to Guide Glucocorticoid Replacement in Autoimmune Addison's Disease 

      Sævik, Åse Bjorvatn; Wolff, Anette Susanne Bøe; Björnsdottir, Sigridur; Simunkova, Katerina; Hynne, Martha Schei; Dolan, David William Peter; Bratland, Eirik; Knappskog, Per M; Methlie, Paal; Carlsen, Siri; Isaksson, Magnus; Bensing, Sophie; Kämpe, Olof; Husebye, Eystein S; Løvås, Kristian; Øksnes, Marianne (Journal article; Peer reviewed, 2021)
      Background No reliable biomarkers exist to guide glucocorticoid (GC) replacement treatment in autoimmune Addison’s disease (AAD), leading to overtreatment with alarming and persistent side effects or undertreatment, which ...

    • The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL 

      Lundåsen, Thomas; Pedrelli, Matteo; Bjørndal, Bodil; Rozell, Björn; Kuiper, Raoul; Burri, Lena; Pavanello, Chiara; Turri, Marta; Skorve, Jon; Berge, Rolf Kristian; Alexson, Stefan E.H.; Tillander, Veronika (Journal article; Peer reviewed, 2020)
      Tetradecylthioacetic acid (TTA) is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including ...

    • Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells 

      Wergeland, Line; Sjøholt, Gry; Haaland, Ingvild; Hovland, Randi; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2007)
      Background: Acute myeloid leukemia (AML) cells are characterized by non-mutated TP53, high levels of Hdm2, and frequent mutation of the Flt3 receptor tyrosine kinase. The juxtamembrane mutation of FLT3 is the strongest ...

    • Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies 

      Yue, Yiyang; Creed, Jordan H.; Cote, David J.; Stampfer, Meir J.; Wang, Molin; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Furtado, Jeremy; Egan, Kathleen; Smith-Warner, Stephanie A. (Journal article; Peer reviewed, 2021)
      Few prospective studies have evaluated the relation between fat-soluble vitamins and glioma risk. Using three cohorts—UK Biobank (UKB), Nurses’ Health Study (NHS), and Health Professionals Follow-Up Study (HPFS), we ...

    • Pre-gestational diabetes: Maternal body mass index and gestational weight gain are associated with augmented umbilical venous flow, fetal liver perfusion, and thus birthweight 

      Lund, Agnethe; Ebbing, Cathrine; Rasmussen, Svein; Qvigstad, Elisabeth; Kiserud, Torvid; Kessler, Jørg (Journal article; Peer reviewed, 2021)
      Objectives To assess how maternal body mass index and gestational weight gain are related to on fetal venous liver flow and birthweight in pregnancies with pre-gestational diabetes mellitus. Methods In a longitudinal ...

    • Preclinical cardiac disease in women and men with primary aldosteronism 

      Aune, Arleen; Kokorina, Marina Victorovna; Grytaas, Marianne Aa.; Midtbø, Helga Bergljot; Løvås, Kristian; Gerdts, Eva (Journal article; Peer reviewed, 2021)
      Purpose: We tested the sex-specific associations between primary aldosteronism (PA), left ventricular (LV) hypertrophy and LV systolic myocardial function. Material and methods: Conventional and speckle tracking ...

    • Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma 

      Hanes, Robert; Munthe, Else; Grad, Iwona; Han, Jianhua; Karlsen, Ida Tveit; Mc Cormack, Emmet; Meza-Zepeda, Leonardo A.; Stratford, Eva Wessel; Myklebost, Ola (Peer reviewed; Journal article, 2019-02-21)
      Background: FGFR inhibition has been proposed as treatment for dedifferentiated liposarcoma (DDLPS) with amplified FRS2, but we previously only demonstrated transient cytostatic effects when treating FRS2-amplified DDLPS ...