Blar i Department of Clinical Science på tittel

Viser treff 1360-1379 av 2310

    • Mapping the human genetic architecture of COVID-19 

      Niemi, Mari E.K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark; Ganna, Andrea; Pathak, Gita A.; Andrews, Shea J.; Kanai, Masahiro; Veerapen, Kumar; Fernandez-Cadenas, Israel; Schulte, Eva C.; Striano, Pasquale; Afset, Jan Egil; Solligård, Erik; Damås, Jan Kristian; Risnes, Kari; Bettini, Laura Rachele; Gustad, Lise Tuset; Holter, Jan Cato; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Folseraas, Trine; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Grimsrud, Marit Mæhle; Vadla, May Sissel; Myhre, Ronny; Kildal, Anders Benjamin; Hoff, Dag Arne Lihaug; Muller, Karl Erik; Heggelund, Lars; Bergan, Jonas; Skogen, Vegard (Journal article; Peer reviewed, 2021)
      The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity ...

    • Markedsføring av naturmidler- en vurdering 

      Tønnesen, Maria Høyland (Master thesis, 2008-06-02)
      Hensikten med oppgaven var å undersøke og sammenligne markedsføringen av naturmidler i kommunikasjonskanalene apotek, helsekostforretninger, Internett, ukeblad og magasiner. I løpet av ti uker ble det samlet inn annonser, ...

    • Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort 

      Celli, Bartolome; Locantore, Nicholas; Yates, Julie C.; Bakke, Per S.; Calverley, Peter M.A.; Crim, Courtney; Coxson, Harvey O.; Lomas, David A.; MacNee, William; Miller, Bruce E.; Mullerova, Hana; Rennard, Stephen I.; Silverman, Edwin K.; Wouters, Emiel F.; Tal-Singer, Ruth; Agusti, Alvar; Vestbo, Jørgen (Journal article; Peer reviewed, 2021)
      Rationale There are no validated measures of disease activity in COPD. Since “active” disease is expected to have worse outcomes (e.g. mortality), we explored potential markers of disease activity in patients enrolled in ...

    • Markers of nephropathy in young Fabry disease patients; role of kidney biopsies and functional measurements 

      Tøndel, Camilla (Doctoral thesis, 2013-04-05)
      Backgound: Fabry disease is an X-linked disease affecting glycosphingolipid metabolism due to deficiency of the lysosomal enzyme α-galactosidase. The natural course of the disease is related to progressive accumulation of ...

    • Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery 

      Kovac, Nina; Grymyr, Lisa Marie Dale; Gerdts, Eva; Nadirpour, Saied; Nedrebø, Bjørn Gunnar; Hjertaas, Johannes Just; Matre, Knut; Cramariuc, Dana (Journal article; Peer reviewed, 2022)
      Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis ...

    • Masked hypertension in obesity: Potential predictors and arterial damage 

      Kenny, Isabel E.; Saeed, Sahrai; Gerdts, Eva; Midtbø, Helga Bergljot; Halland, Hilde; Lønnebakken, Mai Tone (Peer reviewed; Journal article, 2017-02)
      Background: Masked hypertension (MHT), defined as normal office blood pressure (BP) but high ambulatory BP, has been associated with increased cardiovascular risk. Although MHT has been associated with obesity, there is ...

    • Maternal allergen immunisation to prevent sensitisation in offspring: Th2-polarising adjuvants are more efficient than a Th1-polarising adjuvant in mice 

      Ellertsen, Linda K.; Nygaard, Unni C.; Melkild, Ingrid; Løvik, Martinus (Peer reviewed; Journal article, 2010-03-01)
      Background Allergy has been an increasing problem in several parts of the world. Prenatal exposure to allergen and microbial components may affect the development of allergies in childhood, as indicated by epidemiological ...

    • Maternal and child gluten intake and association with type 1 diabetes: The Norwegian Mother and Child Cohort Study 

      Lund-Blix, Nicolai Andre; Tapia, German; Mårild, Karl Staffan; Brantsæter, Anne Lise; Njølstad, Pål Rasmus; Joner, Geir; Skrivarhaug, Torild; Størdal, Ketil; Stene, Lars Christian Mørch (Journal article; Peer reviewed, 2020)
      Background The relationship between maternal gluten intake in pregnancy, offspring intake in childhood, and offspring risk of type 1 diabetes has not been examined jointly in any studies. Our aim was to study the relationship ...

    • Maternal and iatrogenic factors influencing the duration of labour 

      Østborg, Tilde Broch (Doctoral thesis, 2023-06-22)
      Bakgrunn: Forlengede fødselsforløp er den fremste grunnen til keisersnitt og operative vaginale forløsninger på verdensbasis. Imidlertid er definisjonen av normal fødselsprogresjon og varighet gjenstand for en pågående ...

    • Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring 

      Haan, Elis; Sallis, Hannah M.; Ystrøm, Eivind; Njølstad, Pål Rasmus; Andreassen, Ole Andreas; Reichborn-Kjennerud, Ted; Munafo, Marcus R.; Havdahl, Alexandra; Zuccolo, Luisa (Journal article; Peer reviewed, 2021)
      Background: Studies investigating the effects of prenatal alcohol exposure on childhood attention-deficit hyperactivity disorder (ADHD) symptoms using conventional observational designs have reported inconsistent findings, ...

    • Maternal diabetes mellitus and fetal venous liver flow – a longitudinal study 

      Lund, Agnethe (Doctoral thesis, 2019-06-13)
      Background: Despite adequate glycemic control, the risks of perinatal complications and fetal macrosomia are increased in pregnancies with pregestational diabetes (PGDM). Maternal overweight, obesity and excess gestational ...

    • Maternal influence on fetal size and use of longitudinal fetal surveillance in predicting adverse perinatal outcomes 

      Karlsen, Henriette Odland (Doctoral thesis, 2016-06-15)
      Background: Fetal growth is influenced by maternal factors, but also more specifically determined by level of fetoplacental circulation. We tested the hypothesis that fetal abdominal circumference (AC) in the second trimester ...

    • Maternal microchimerism in cord blood and risk of childhood-onset type 1 diabetes 

      Tapia, German; Mortimer, Georgina; Ye, Jody; Gillard, Benjamin Thomas; Chipper-Keating, Saranna; Mårild, Karl Staffan; Viken, Marte K; Lie, Benedicte Alexandra; Joner, Geir; Skrivarhaug, Torild; Njølstad, Pål Rasmus; Størdal, Ketil; Gillespie, Kathleen; Stene, Lars Christian Mørch (Peer reviewed; Journal article, 2019-09)
      Background: Maternal microchimerism (MMc), the transmission of small quantities of maternal cells to the fetus, is relatively common and persistent. MMc has been detected with increased frequency in the circulation and ...

    • Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study 

      Hanem, Liv Guro Engen; Salvesen, Øyvind; Madsen, Andre; Sagen, Jørn Vegard; Mellgren, Gunnar; Juliusson, Petur Benedikt; Carlsen, Sven Magnus; Vanky, Eszter; Ødegård, Rønnaug (Journal article; Peer reviewed, 2021)
      Objective: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with potential effects on offspring both genetically and through altered intrauterine environment. Metformin, which ameliorate hormonal disturbances ...

    • Maternal physical activity affects yolk sac size and growth in early pregnancy, but girls and boys use different strategies 

      Vietheer, Alexander; Kiserud, Torvid; Ebbing, Cathrine; Rajkumar, Hemamaalini; Haaland, Øystein Ariansen; Lie, Rolv T.; Romero, Roberto; Kessler, Jørg (Journal article; Peer reviewed, 2023)
      This longitudinal study investigated the impact of actigraphy-measured maternal physical activity on yolk sac size during early development. The yolk sac, a transient extraembryonic organ, plays a crucial role in embryonic ...

    • Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero 

      Rotroff, Daniel M; Joubert, Bonnie R; Marvel, Skylar W; Håberg, Siri Eldevik; Wu, Michael C; Nilsen, Roy Miodini; Ueland, Per Magne; Nystad, Wenche; London, Stephanie J; Motsinger-Reif, Alison (Peer reviewed; Journal article, 2016-11-25)
      Background: Children exposed to maternal smoking during pregnancy exhibit increased risk for many adverse health effects. Maternal smoking influences methylation in newborns at specific CpG sites (CpGs). Here, we extend ...

    • Matrix M Adjuvanted H5N1 Vaccine Elicits Broadly Neutralizing Antibodies and Neuraminidase Inhibiting Antibodies in Humans That Correlate With In Vivo Protection 

      Zhou, Fan; Hansen, Lena; Pedersen, Gabriel Kristian; Grødeland, Gunnveig; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      The highly pathogenic avian influenza H5N1 viruses constantly evolve and give rise to novel variants that have caused widespread zoonotic outbreaks and sporadic human infections. Therefore, vaccines capable of eliciting ...

    • Matrix M H5N1 vaccine induces cross-H5 clade humoral immune responses in a randomized clinical trial and provides protection from highly pathogenic influenza challenge in ferrets 

      Cox, Rebecca Jane; Major, Diane; Pedersen, Gabriel Kristian; Pathirana, Rishi; Höschler, Katja; Guilfoyle, Kate; Roseby, Sarah; Bredholt, Geir; Assmus, Jörg; Breakwell, Lucy; Campitelli, Laura; Sjursen, Haakon (Peer reviewed; Journal article, 2015-07-06)
      Background and Methods: Highly pathogenic avian influenza (HPAI) viruses constitute a pandemic threat and the development of effective vaccines is a global priority. Sixty adults were recruited into a randomized clinical ...

    • MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk 

      Gansmo, Liv Beathe; Bjørnslett, Merete Pauline; Halle, Mari Kyllesø; Salvesen, Helga; Romundstad, Pål Richard; Hveem, Kristian; Vatten, Lars Johan; Dørum, Anne; Lønning, Per Eystein; Knappskog, Stian (Peer reviewed; Journal article, 2017-02-03)
      Background: The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with ...

    • MDM2 Promoter SNP344T>A (rs1196333) Status Does Not Affect Cancer Risk 

      Knappskog, Stian; Gansmo, Liv B.; Romundstad, Pål; Bjørnslett, Merete; Trovik, Jone; Lønning, Per Eystein; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2012-04-30)
      The MDM2 proto-oncogene plays a key role in central cellular processes like growth control and apoptosis, and the gene locus is frequently amplified in sarcomas. Two polymorphisms located in the MDM2 promoter P2 have been ...