Browsing Department of Clinical Science by Title

Now showing items 565-584 of 2310

    • Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy 

      Gjertsen, Bjorn T; Schöffski, Patrick (Peer reviewed; Journal article, 2015)
      Owing to their integral involvement in cell cycle regulation, the Polo-like kinase (Plk) family, particularly Plk1, has emerged as an attractive therapeutic target in oncology. In recent years, several Plk1 inhibitors have ...

    • Discovery of novel candidates for anti- liposarcoma therapies by medium-scale high-throughput drug screening 

      Grad, Iwona; Hanes, Robert; Ayuda-Durán, Pilar; Kuijjer, Marieke Lydia; Enserink, Jorrit; Meza-Zepeda, Leonardo A; Myklebost, Ola (Journal article; Peer reviewed, 2021)
      Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment alternatives beyond traditional chemotherapeutic regimes are much needed. So far, tumor mutation analysis has not led to significant treatment ...

    • Discovery of novel potential reversible peptidyl arginine deiminase inhibitor 

      Aliko, Ardita; Kaminska, Marta; Falkowski, Katherine; Bielecka, Ewa; Benedyk-Machaczka, Malgorzata; Malicki, Stanislaw; Koziel, Joanna; Wong, Alicia; Bryzek, Danuta; Kantyka, Tomasz Tadeusz; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2019)
      Citrullination, a posttranslational modification, is catalyzed by peptidylarginine deiminases (PADs), a unique family of enzymes that converts peptidyl-arginine to peptidyl-citrulline. Overexpression and/or increased PAD ...

    • Discovery of shared genomic loci using the conditional false discovery rate approach 

      Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Fan, Chun Chieh; Bahrami, Shahram; Holland, Dominic; Djurovic, Srdjan; Thompson, Wesley Kurt; Dale, Anders; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2020)
      In recent years, genome-wide association study (GWAS) sample sizes have become larger, the statistical power has improved and thousands of trait-associated variants have been uncovered, offering new insights into the genetic ...

    • Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination 

      Tete, Sarah; Krammer, Florain; Jalloh, Sarah Larteley Lartey; Bredholt, Geir; Wood, John M.; Skrede, Steinar; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016-07-28)
      Traditionally, neutralising antibodies that are directed to the major surface glycoprotein hemagglutinin (HA) head domain are measured as surrogate correlates of protection against influenza. In addition to neutralization, ...

    • Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors 

      Mullins, Niamh; Kang, JooEun; Campos, Adrian I.; Coleman, Jonathan R.I.; Edwards, Alexis C.; Galfalvy, Hanga; Levey, Daniel F.; Lori, Adriana; Shabalin, Andrey A; Andreassen, Ole; Melle, Ingrid; Morken, Gunnar; Starnawska, Anna; Su, Mei-Hsin; Watson, Hunna J; Adams, Mark; Awasthi, Swapnil; Gandal, Michael; Hafferty, Jonathan; Hishimoto, Akitoyo; Kim, Minsoo; Okazaki, Satoshi; Otsuka, Ikuo; Ware, Erin B.; Stephan, Ripke; Bergen, Andrew W.; Berrettini, Wade H.; Bohus, Martin; Brandt, Harry; Chang, Xiao; Chen, Wei J; Chen, Hsi-Chung; Crawford, Steven; Crow, Scott; DiBlasi, Emily; Duriez, Philibert; Fichter, Manfred M; Fernández-Aranda, Fernando; Gallinger, Steven; Glatt, Stephen J.; Gorwood, Philip; Guo, Yiran; Hakonarson, Hakon; Halmi, Katherine A; Hwu, Hai-Gwo; Jain, Sonia; Jamain, Stephane; Jimenez-Murcia, Susana; Johnson, Craig; Djurovic, Srdjan (Journal article; Peer reviewed, 2022)
      Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic ...

    • Distant metastasis dynamics following subsequent surgeries after primary breast cancer removal 

      Demicheli, Romano; Dillekås, Hanna; Straume, Oddbjørn; Biganzoli, Elia (Peer reviewed; Journal article, 2019)
      Background: The aim of the research was to separate the distant metastasis (DM) enhancing effect due to breast tumour removal from that due to surgical manoeuvre by itself. Methods: DM dynamics following surgery for ...

    • Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies 

      Leclair, Valérie; Galindo-Feria, Angeles S.; Rothwell, Simon; Kryštůfková, Olga; Zargar, Sepehr Sarrafzadeh; Mann, Herman; Diederichsen, Louise Pyndt; Andersson, Anna Helena; Klein, Martin; Tansley, Sarah; Rönnblom, Lars; Lindblad-Toh, Kerstin; Syvänen, Ann-Christine; Wahren Herlenius, Marie Elisabeth; Sandling, Johanna K.; Bianchi, Matteo; Lundberg, Ingrid E.; Padyukov, Leonid; Molberg, Øyvind; Lamb, Janine A.; Chinoy, Hector; Holmqvist, Marie; Diaz-Gallo, Lina-Marcela (Journal article; Peer reviewed, 2023)
      Background In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles ...

    • Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders 

      Doan, Nhat Trung; Kaufmann, Tobias; Bettella, Francesco; Jørgensen, Kjetil Nordbø; Brandt, Christine Lycke; Moberget, Torgeir; Alnæs, Dag; Douaud, Gwenaëlle; Duff, Eugene; Djurovic, Srdjan; Melle, Ingrid; Ueland, Torill; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2017-06-09)
      The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is ...

    • Distinct pathophysiological pathways in women and men with heart failure 

      Ravera, Alice; Santema, Bernadet T.; de Boer, Rudolf A.; Anker, Stefan D.; Samani, Nilesh J.; Lang, Chim C.; Ng, Leong; Cleland, John G.F.; Dickstein, Kenneth; Lam, Carolyn S.P.; Van Spall, Harriette G. C.; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Metra, Marco; Voors, Adriaan A.; Sama, Iziah E. (Journal article; Peer reviewed, 2022)
      Aims: Clinical differences between women and men have been described in heart failure (HF). However, less is known about the underlying pathophysiological mechanisms. In this study, we compared multiple circulating biomarkers ...

    • Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine 

      Bredholt, Therese; Ersvær, Elisabeth; Erikstein, Bjarte Skoe; Sulen, André; Reikvam, Håkon; Aarstad, Hans Jørgen; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2013-07-11)
      Background: Amphetamine and amphetamine derivatives are suggested to induce an immunosuppressive effect. However, knowledge of how amphetamines modulate intracellular signaling pathways in cells of the immune system is ...

    • Distinct T and NK cell populations may serve as immune correlates of protection against symptomatic pandemic influenza A(H1N1) virus infection during pregnancy 

      Savic, Miloje; Dembinski, Jennifer Lynn; Laake, Ida; Hungnes, Olav; Cox, Rebecca Jane; Oftung, Fredrik; Trogstad, Lill; Mjaaland, Siri (Peer reviewed; Journal article, 2017-11-16)
      Maternal influenza infection during pregnancy is associated with increased risk of morbidity and mortality. However, the link between the anti-influenza immune responses and health-related risks during infection is not ...

    • Distinct T cell subsets in adipose tissue are associated with obesity 

      Haugstøyl, Martha Eimstad; Cornillet, Martin; Strand, Kristina; Stiglund, Natalie; Sun, Dan; Lawrence-Archer, Laurence; Hjellestad, Iren Drange; Sparrelid, Ernesto; Busch, Christian; Hjelmesæth, Jøran Sture; Hertel, Jens Kristoffer; Ponzetta, Andrea; Mellgren, Gunnar; Fernø, Johan; Björkström, Niklas K. (Journal article; Peer reviewed, 2022)
      Adipose tissue inflammation is a driving factor for the development of obesity-associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro-inflammatory signaling is emerging. However, data ...

    • Distinctions Between Self-Report and Performance-Based Measures of Physical Function in Older Patients Prior to Chemotherapy 

      Torstveit, Ann Helen; Løyland, Borghild; Grov, Ellen Karine; Guren, Marianne; Paul, Steven M.; Ritchie, Christine; Vistad, Ingvild; Miaskowski, Christine; Utne, Inger (Journal article; Peer reviewed, 2021)
      Background: The maintenance of physical function (PF) is an extremely important outcome for older adults. Objective: The aims of this study were to, identify differences in subjective and objective measures of PF between ...

    • Distribution of psychotropic drugs into lipoproteins 

      Serkland, Trond T.; Schjøtt, Jan; Berg, Jon Andsnes; Herfindal, Lars; Riedel, Bettina; Skrede, Silje (Peer reviewed; Journal article, 2019)
      Aim: The aim of this pilot study was to investigate whether psychotropic drugs frequently analyzed in a routine therapeutic drug monitoring laboratory bind to low-density lipoproteins/very-low-density lipoproteins (LDL/VLDL) ...

    • Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances 

      Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Skarpengland, Tonje; Berge, Rolf Kristian; Fevang, Børre; Halvorsen, Bente; Aukrust, Pål (Journal article; Peer reviewed, 2023)
      The relationship between metabolic and inflammatory pathways play a pathogenic role in various cardiometabolic disorders and is potentially also involved in the pathogenesis of other disorders such as cancer, autoimmunity ...

    • DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival 

      Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas; Rye, Morten Beck; Knappskog, Stian; Eikesdal, Hans Petter; Lønning, Per Eystein; Tost, Jörg; Kristensen, Vessela N.; Tessem, May-Britt; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2022)
      Background: Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ...

    • DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response 

      Dejeux, Emelyne; Rønneberg, Jo A.; Solvang, Hiroko Kato; Bukholm, Ida Rashida Khan; Geisler, Stephanie; Aas, Turid; Gut, Ivo G.; Børresen-Dale, Anne-Lise; Lønning, Per Eystein; Kristensen, Vessela N.; Tost, Jörg (Peer reviewed; Journal article, 2010-03-25)
      Background: Breast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics. In this study, we aimed to ...

    • DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy 

      Reese, Sarah E; Zhao, Shanshan; Wu, Michael C; Joubert, Bonnie R; Parr, Christine Louise; Håberg, Siri Eldevik; Ueland, Per Magne; Nilsen, Roy Miodini; Midttun, Øivind; Vollset, Stein Emil; Peddada, Shyamal D; Nystad, Wenche; London, Stephanie J (Peer reviewed; Journal article, 2017-04)
      Background: Maternal smoking during pregnancy, especially when sustained, leads to numerous adverse health outcomes in offspring. Pregnant women disproportionately underreport smoking and smokers tend to have lower follow-up ...

    • The DNA methylome of cervical cells can predict the presence of ovarian cancer 

      Barrett, James E.; Jones, Allison; Evans, Iona; Reisel, Daniel; Herzog, Chiara; Chindera, Kantaraja; Kristiansen, Mark; Leavy, Olivia C.; Manchanda, Ranjit; Bjørge, Line; Zikan, Michal; Cibula, David; Widschwendter, Martin (Journal article; Peer reviewed, 2022)
      The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived ...