Browsing Department of Clinical Medicine by Title
Now showing items 1219-1238 of 2099
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Long-term survival of 2997 finger metacarpophalanageal joint arthroplasties from the Norwegian Arthroplasty Register
(Journal article; Peer reviewed, 2022)We present the long-time survival of 2997 primary metacarpophalangeal (MCP) joint implants from the Norwegian Arthroplasty Register from 1994 to 2019. Six different implants were compared in terms of survival and risk of ... -
Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes
(Journal article; Peer reviewed, 2023-07-21)Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and ... -
Longer-term quality of care, effectiveness, and cost-effectiveness of implementing a model of care for osteoarthritis: A cluster-randomized controlled trial
(Journal article; Peer reviewed, 2024)Objective: To assess the quality of care, effectiveness, and cost-effectiveness over 12 months after implementing a structured model of care for hip and knee osteoarthritis (OA) in primary healthcare as compared to usual ... -
Longevity of B-cell and T-cell responses after live attenuated influenza vaccination in children
(Peer reviewed; Journal article, 2015-05-15)Background. The live attenuated influenza vaccine (LAIV) is the preferred vaccine for children, but the mechanisms behind protective immune responses are unclear, and the duration of immunity remains to be elucidated. This ... -
Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease
(Journal article; Peer reviewed, 2023)Background Brain innate immune activation is associated with Alzheimer’s disease (AD), but degrees of activation may vary between disease stages. Thus, brain innate immune activation must be assessed in longitudinal ... -
Longitudinal effects of adjuvant chemotherapy and lymph node staging on patient-reported outcomes in endometrial cancer survivors: a prospective cohort study
(Journal article; Peer reviewed, 2021)Background: Most patients with endometrial cancer with localized disease are effectively treated and survive for a long time. The primary treatment is hysterectomy, to which surgical staging procedures may be added to ... -
Longitudinal follow-up of employment status in patients with chronic fatigue syndrome after mononucleosis
(Peer reviewed; Journal article, 2015-11-26)Objective: To examine the effect of early clinical and demographic factors on occupational outcome, return to work or awarded permanent disability pension in young patients with chronic fatigue syndrome (CFS). Design: ... -
A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue
(Peer reviewed; Journal article, 2019-01-06)High mammographic density (MD) is associated with a 4–6 times increase in breast cancer risk. For post-menopausal women,MD often decreases over time, but little is known about the underlying biological mechanisms. MD ... -
Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells
(Journal article; Peer reviewed, 2023)A primary function of DNA methylation in mammalian genomes is to repress transposable elements (TEs). The widespread methylation loss that is commonly observed in cancer cells results in the loss of epigenetic repression ... -
Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma
(Journal article; Peer reviewed, 2020)Background We previously showed a tumor‐suppressive function of S100A14 in oral squamous cell carcinoma (OSCC). This study aimed to examine the prognostic significance and differentiation‐related function of S100A14 in ... -
The Low Affinity Nerve Growth Factor Receptor p75NTR Identifies a Transient Stem Cell-Like State in Oral Squamous Cell Carcinoma Cells
(Peer reviewed; Journal article, 2014-09-12)Background Although several markers have been used for enrichment of cells with stem cell-like properties in oral squamous cell carcinoma (OSCC), isolation of a pure subpopulation is still a challenging task. Normal oral ... -
Low birth weight and risk of progression to end stage renal disease in IgA nephropathy - A retrospective registry-based cohort study
(Peer reviewed; Journal article, 2016-04-19)Background: Low Birth Weight (LBW) is a surrogate for fetal undernutrition and is associated with impaired nephron development in utero. In this study, we investigate whether having been born LBW and/or small for gestational ... -
Low birth weight and risk of progressive kidney disease. Epidemiological and morphological studies
(Doctoral thesis, 2016-10-19)Background: Low Birth Weight (LBW) and Small for Gestation Age (SGA) are surrogate markers for fetal undernutrition and are associated with impaired nephron development in utero as suggested by the Brenner`s hypothesis. ... -
Low birth weight, intrauterine growth restriction and risk of chronic kidney disease in adult age
(Doctoral thesis, 2022-06-16)Background and aims: Studies have shown that adults with low birth weight (LBW) face an increased risk for chronic kidney disease (CKD), high blood pressure and cardiovascular disease (CVD). Previous Norwegian studies have ... -
Low birthweight is associated with lower glomerular filtration rate in middle-aged mainly healthy women
(Journal article; Peer reviewed, 2020)Background Low birthweight (LBW) has been shown to increase the risk of severe kidney disease. Studies have also shown associations between LBW and lower estimated glomerular filtration rate (GFR) in young adults. In this ... -
Low bone density and high morbidity in patients between 55 and 70 years with displaced femoral neck fractures: A case-control study of 50 patients vs 150 normal controls
(Peer reviewed; Journal article, 2019-08-14)Background A displaced femoral neck fracture (FNF) in patients 55-70 years is a serious injury with a high risk of treatment failure and the optimal surgical treatment remains unclear. We aimed to describe characteristics ... -
Low Densities of Serotonin and Peptide YY Cells in the Colon of Patients with Irritable Bowel Syndrome
(Peer reviewed; Journal article, 2011-11-05)Background The gut hormones are important in regulating gastrointestinal motility. Disturbances in gastrointestinal motility have been reported in patients with irritable bowel syndrome (IBS). Reduced endocrine cell density, ... -
Low infection rates after 34,361 intramedullary nail operations in 55 low- and middle-income countries. Validation of the Surgical Implant Generation Network (SIGN) Online Surgical Database
(Peer reviewed; Journal article, 2011-12)Background: The Surgical Implant Generation Network (SIGN) supplies intramedullary (IM) nails for the treatment of long bone fractures free of charge to hospitals in low- and middle-income countries (LMICs). Most operations ... -
Low rate of local recurrence detection by rectoscopy in follow-up of rectal cancer
(Peer reviewed; Journal article, 2020)Aim: The main aim of this study was to examine the effectiveness of rectoscopy for detecting local recurrence of rectal cancer in patients following low anterior resection. Method: This was a retrospective study of 201 ...