Browsing Department of Clinical Medicine by Title
Now showing items 2049-2068 of 2154
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Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNA
(Journal article; Peer reviewed, 2022)While DNA methylation is established as a major regulator of gene expression in the nucleus, the existence of mitochondrial DNA (mtDNA) methylation remains controversial. Here, we characterized the mtDNA methylation landscape ... -
Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation
(Journal article; Peer reviewed, 2022)Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ... -
Ultrasonographic evaluation of disease activity in Crohn’s Disease
(Doctoral thesis, 2020-09-21)Background: Crohn's disease (CD) is a chronic inflammatory disorder in the gastrointestinal (GI) tract, characterized by alternating periods of remission and relapse. Patients’ symptoms do not reliably represent inflammatory ... -
Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys
(Journal article; Peer reviewed, 2021-11-29)The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ... -
Ultrasound Detection of Pneumothorax. Development of a porcine pneumothorax model to assess and teach lung ultrasound diagnostics.
(Doctoral thesis, 2013-10-21)Background: Pneumothorax (PTX) is common after blunt chest injury, and failure to diagnose and rapidly treat an enlarging PTX may cause patient death. The anteroposterior supine chest x-ray (CXR) is the least sensitive of ... -
Ultrasound echo-intensity predicts severe Pancreatic affection in cystic fibrosis patients
(Peer reviewed; Journal article, 2015-03-24)Background: Pancreatic destruction affects the majority of patients with cystic fibrosis. We aimed to relate ultrasound findings to exocrine pancreatic function and cystic fibrosis genotype. Methods: Patients with cystic ... -
Ultrasound imaging for assessing functions of the GI tract
(Journal article; Peer reviewed, 2021)Objective: In the following review we outline how ultrasound can be used to measure physiological processes in the gastrointestinal tract. Approach: We have investigated the potential of ultrasound in assessing ... -
Ultrasound Strain Rate Imaging in Functional Dyspepsia : in-vitro and clinical evaluation
(Doctoral thesis, 2008-06-20)Functional dyspepsia (FD) is a chronic condition that is characterized by abdominal pain or discomfort, nausea, vomiting, early satiation and abdominal fullness. The Rome III classification of functional gastrointestinal ... -
Ultrasound-Assisted Endoscopic Removal of Pretibial Cysts Related to Biointerference Screw Degradation
(Journal article; Peer reviewed, 2021)We report on the treatment of cases of painful subcutaneous pretibial cyst due to broken and displaced materials of only partly absorbed bioabsorbable interference screws used for anterior cruciate ligament reconstruction. ... -
Umbilical vein constriction at the abdominal wall An ultrasound study in low risk pregnancies
(Doctoral thesis, 2005-05-18)The umbilical vein is the only vessel supplying the fetus with blood supplying oxygen and nutrients from the placenta. Case reports indicate that the fetal end of the umbilical cord is susceptible to mechanical complications. ... -
The unmet need for treatment of children with musculoskeletal impairment in Malawi
(Journal article; Peer reviewed, 2022)Background: More than a billion people globally are living with disability and the prevalence is likely to increase rapidly in the coming years in low- and middle-income countries (LMICs). The vast majority of those living ... -
Unsubstantiated belief in the diagnostic accuracy of the triad of abusive head trauma may lead to incorrect diagnoses of alleged abuse cases
(Journal article; Peer reviewed, 2021) -
An Update on Vitamin D and Disease Activity in Multiple Sclerosis
(Peer reviewed; Journal article, 2019)Vitamin D and its main active metabolite 1,25-dihydroxyvitamin D serve a crucial role in maintenance of a healthy calcium metabolism, yet have additional roles in immune and central nervous system cell homeostasis. Serum ... -
Upgrades from Previous Cardiac Implantable Electronic Devices Compared to De Novo Cardiac Resynchronization Therapy Implantations: Results from CRT Survey-II in the Turkish Population
(Journal article; Peer reviewed, 2022)Objective: Cardiac resynchronization therapy is the guideline-directed treatment option in selected heart failure with reduced left ventricular ejection fraction patients. Data regarding the contemporary clinical practice ... -
Ureteral access sheaths and its use in the future: A comprehensive update based on a literature review
(Journal article; Peer reviewed, 2022-08-31)Ureteral access sheaths (UASs) are part of urologist’s armamentarium when performing retrograde intrarenal surgery (RIRS). Recently, the world of RIRS has changed dramatically with the development of three game-changers: ... -
Ureteral Strictures Following Ureteroscopic Stone Treatment
(Journal article; Peer reviewed, 2021)Background and Purpose: Ureteral stricture is a rare, but serious complication following ureteroscopy (URS) for stones. The aim of this study was to investigate how many patients ended up with a ureteral stricture after ... -
Ureteroscopy for stone disease in the paediatric population: lessons learned and outcomes in a Nordic setting
(Journal article; Peer reviewed, 2022)Introduction: Paediatric stone disease is rare in the Nordic communities. Still, the condition can require surgical intervention in the form of ureteroscopy (URS). Here, we report outcomes achieved at a regional (tertiary) ... -
Ureteroscopy in Patients with Urinary Diversion: Outcomes and Lessons Learned from Two European Centres
(Journal article; Peer reviewed, 2023)Background: Ureteroscopy (URS) in patients with urinary diversion is technically challenging. Common difficulties include anastomotic strictures, tortuosity, and failure to cannulate the ureteric orifice. There are few ... -
Urinary iodine concentration and iodine intake in pregnant Norwegian women. Results from the “Little in Norway” Study (LiN)
(Master thesis, 2015-05-15)Background Iodine is an essential nutrient for the synthesis of thyroid hormones. Inadequate iodine intake is especially critical during pregnancy, lactation and early childhood. Iodine deficiency early in life impairs the ... -
Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study
(Journal article; Peer reviewed, 2022)Introduction Asthma is a heterogeneous disease with poorly defined phenotypes. Patients with severe asthma often receive multiple treatments including oral corticosteroids (OCS). Treatment may modify the observed metabotype, ...