Browsing Department of Clinical Medicine by Title
Now showing items 111-130 of 1227
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C- reactive protein in schizophrenia-spectrum disorders; relationship to cognitive functions and medications
(Doctoral thesis, 2019-12-05)Background: Schizophrenia spectrum disorders are severe mental illnesses characterized by psychotic symptoms, cognitive dysfunction and functional decline. Cognitive impairments have been recognized as core features of ... -
C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease
(Peer reviewed; Journal article, 2017-07-31)The pan lymphocyte marker CD45 exists in various isoforms arising from alternative splicing of the exons 4, 5 and 6. While naïve T cells express CD45RA translated from an mRNA containing exon 4, exons 4–6 are spliced out ... -
Can bone apposition predict the retention force of a femoral stem? An experimental weight-bearing hip-implant model in goats
(Peer reviewed; Journal article, 2015-04-28)Background: The increasing incidence of prosthesis revision surgery in the Western world has led to an increased focus on the capacity for stem removal. We previously reported on a femoral stem implanted in goats with an ... -
Can the cardiovascular family history reported by our patients be trusted? The Norwegian Stroke in the Young Study
(Peer reviewed; Journal article, 2016-01)Background and purpose: Family history (FH) is used as a marker for inherited risk. Using FH for this purpose requires the FH to reflect true disease in the family. The aim was to analyse the concordance between young and ... -
Cancer and Total Hip Replacement. Cancer as a risk factor for prosthesis and prosthesis as a risk factor for cancer
(Doctoral thesis, 2015-09-18)Annually, 14 million new cancer cases are detected worldwide; the numbers are expected to rise by 70% over the next decades. In Norway, 30,000 new cancer cases are detected every year. Because of screenings and increased ... -
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
(Peer reviewed; Journal article, 2017-05-17)The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ... -
Cancer cell line-specific protein profiles in extracellular vesicles identified by proteomics
(Journal article; Peer reviewed, 2020-09-04)Extracellular vesicles (EVs), are important for intercellular communication in both physiological and pathological processes. To explore the potential of cancer derived EVs as disease biomarkers for diagnosis, monitoring, ... -
Cancer epigenetics in solid organ tumours: A primer for surgical oncologists
(Peer reviewed; Journal article, 2019-05)Cancer is initiated through both genetic and epigenetic alterations. The end-effect of such changes to the DNA machinery is a set of uncontrolled mechanisms of cell division, invasion and, eventually, metastasis. Epigenetic ... -
Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study
(Peer reviewed; Journal article, 2017-12-18)Background. Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. Objectives. To quantify the cancer risk associated with contemporary ... -
Cancer Stem Cell-Related Markers in Normal and Neoplastic Oral Mucosa. A study on human samples and experimental models
(Doctoral thesis, 2014-06-04)The existence of cancer stem cells (CSCs) in solid cancers is still a controversial issue. Several markers were successfully used to enrich for cells with stem cell-like properties in oral squamous cell carcinoma (OSCC). ... -
Cancer-Associated Ischemic Stroke: The Bergen NORSTROKE Study
(Doctoral thesis, 2018-05-25)Background: Stroke and cancer are both leading causes of death and disability in the Western world. Cancer can lead to a hypercoagulable state that can cause ischemic stroke. Mechanisms include disturbance of the coagulation ... -
Cancer-Associated troke: The Bergen NORSTROKE Study
(Peer reviewed; Journal article, 2015-10-13)Background: Underlying malignancy can cause ischemic stroke in some patients. Mechanisms include the affection of the coagulation cascade, tumor mucin secretion, infections and nonbacterial endocarditis. The release of ... -
The cannabis pathway to non-affective psychosis may reflect less neurobiological vulnerability
(Peer reviewed; Journal article, 2014-11-18)There is a high prevalence of cannabis use reported in non-affective psychosis. Early prospective longitudinal studies conclude that cannabis use is a risk factor for psychosis, and neurochemical studies on cannabis have ... -
Capillary leakage in post-cardiac arrest survivors during therapeutic hypothermia - a prospective, randomised study
(Peer reviewed; Journal article, 2010-05-25)Background: Fluids are often given liberally after the return of spontaneous circulation. However, the optimal fluid regimen in survivors of cardiac arrest is unknown. Recent studies indicate an increased fluid requirement ... -
Carboxyl-ester lipase in human pancreatic disease. A study with focus on genetics, glycosylation and ABO blood groups
(Doctoral thesis, 2018-09-28)Glycosylation is a post-translational modification where carbohydrates are attached to a protein or other organic molecule. Defects in glycosylation are seen in many human pathologies and may even be the underlying cause ... -
Cardiac Arrest in a Community: Epidemiology, Treatment, and Outcome
(Doctoral thesis, 2017-09-01)Background: Incidence and mortality from sudden cardiac arrest is high, making it a prevalent cause of death. Both incidence and survival rates show great variability between populations. In order to improve survival from ... -
Carotid intima-media thickness and cerebrovascular vasoreactivity in patients with intracranial aneurysms : A sonographic study of potential predictors for aneurysm rupture risk and delayed cerebral ischemia
(Doctoral thesis, 2020-04-03)Background and aims Intracranial aneurysms can rupture and cause an aneurysmal subarachnoid hemorrhage (aSAH), a bleeding under the arachnoid meninges covering the brain. This is a devastating event, in which delayed ... -
Case-control study of food intake, nausea and vomiting of pregnant women
(Master thesis, 2014-05-15)Background: Severe pregnancy induced nausea and vomiting, also known as Hyperemesis gravidarum (HG), can lead to significant reduced quality of life (QOL) and of food intake. Untreated this can potentially harm both mother ... -
Causal modelling of variation in clinical practice and long-term outcomes of ADHD using Norwegian registry data: The ADHD controversy project
(Journal article; Peer reviewed, 2021)Introduction Attention-deficit/hyperactivity disorder (ADHD) is among the most common mental disorders in children and adolescents, and it is a strong risk factor for several adverse psychosocial outcomes over the lifespan. ... -
The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study
(Peer reviewed; Journal article, 2017-06)Objective: Smoking has been associated with a reduced risk of hip and knee osteoarthritis (OA) and subsequent joint replacement. The aim of the present study was to assess whether the observed association is likely to be ...