Blar i Department of Clinical Medicine på tittel
Viser treff 1557-1576 av 2087
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Pneumomediastinum etter sternalpunksjon
(Journal article; Peer reviewed, 2021) -
PNKP Mutations Identified by Whole-Exome Sequencing in a Norwegian Patient with Sporadic Ataxia and Edema
(Journal article, 2017-02)We identified PNKP mutations in a Norwegian woman with AOA. This patient had the typical findings with cognitive dysfunction, peripheral neuropathy, cerebellar dysarthria, horizontal nystagmus, oculomotor apraxia, and ... -
Podocan and Adverse Clinical Outcome in Patients Admitted With Suspected Acute Coronary Syndromes
(Journal article; Peer reviewed, 2022)Background: Markers of bone and extracellular matrix (ECM) remodeling may be associated with adverse outcomes in atherosclerotic cardiovascular disease. Podocan is a newly discovered ECM glycoprotein, previously not studied ... -
Point-of-care ultrasound of the gastrointestinal tract
(Journal article; Peer reviewed, 2023)The widespread use of portable ultrasound scanners has promoted the concept of point of care ultrasound (POCUS), namely “ultrasound performed bedside and interpreted directly by the clinician.” The purpose of this short ... -
POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia
(Journal article; Peer reviewed, 2023)Diseases caused by POLG mutations are the most common form of mitochondrial diseases and associated with phenotypes of varying severity. Clinical studies have shown that patients with compound heterozygous POLG mutations ... -
POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition
(Journal article; Peer reviewed, 2022)We showed previously that POLG mutations cause major changes in mitochondrial function, including loss of mitochondrial respiratory chain (MRC) complex I, mitochondrial DNA (mtDNA) depletion and an abnormal NAD+/NADH ratio ... -
Polio and post-polio syndrome in non-Western immigrants: A new challenge for the healthcare system in Norway
(Peer reviewed; Journal article, 2019)Objective: To explore the health situation and identify specific health challenges in non-Western immigrants with polio in Norway, by comparing their status with Western immigrants with polio and native Norwegians with ... -
Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix
(Peer reviewed; Journal article, 2019)Several proteins linked to familial Parkinson disease have been associated with mitochondrial (dys-)function and have been described to reside within mitochondria. The putative mitochondrial and sub-mitochondrial localization ... -
Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
(Journal article; Peer reviewed, 2021)Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship ... -
Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users
(Peer reviewed; Journal article, 2012-10-27)Introduction: Mammographic density (MD) is one of the strongest known breast cancer risk factors. Estrogen and progestin therapy (EPT) has been associated with increases in MD. Dense breast tissue is characterized by ... -
Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort : a case control study
(Peer reviewed; Journal article, 2006-03-16)Background: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in ... -
Polyvinylpyrrolidone deposition disease : The role of pathology in understanding disease and death in persons with opioid addiction and intravenous drug use
(Doctoral thesis, 2023-10-13)Bakgrunn og målsetting: Polymeren polyvinylpyrrolidon (PVP) er mye brukt som tilsetningsstoff i legemidler. PVP med høy molekylvekt kan ikke utskilles via nyrene og vil derfor opphopes i kroppens vev dersom det administreres ... -
Polyvinylpyrrolidone deposition disease in patients with intravenous opioid use: a case series
(Journal article; Peer reviewed, 2021)The polymer polyvinylpyrrolidone (PVP) is an excipient widely used in prescription drugs. Depending on the molecular weight (MW), parenterally administered PVP may accumulate in various tissues. Consequently, moderate and ... -
Poor Sleep in Patients with Multiple Sclerosis
(Peer reviewed; Journal article, 2012-11-14)Background: Poor sleep is a frequent symptom in patients with multiple sclerosis (MS). Sleep may be influenced by MS-related symptoms and adverse effects from immunotherapy and symptomatic medications. We aimed to study ... -
A population based study on Kidney Cancer in Norway (2008 - 2013). Aspects of biopsy use, surgical treatment and outcome
(Doctoral thesis, 2018-11-02)Aims: The aim of this study was to explore whole nation data, reveal trends and obtain updated numbers on kidney cancer (KC) treatment in the six-year period from 2008- 2013. The field of KC management has undergone ... -
A Porcine Pneumothorax Model for Teaching Ultrasound Diagnostics
(Peer reviewed; Journal article, 2012-05)Objectives: Ultrasound (US) is a sensitive diagnostic tool for detecting pneumothorax (PTX), but methods are needed to optimally teach this technique outside of direct patient care. In training and research settings, porcine ... -
Portal and umbilical venous distribution in the human fetus : a longitudinal ultrasound study
(Doctoral thesis, 2007-06-26)Knowledge of the venous perfusion of the human fetal liver is fragmentary and mainly limited to the umbilical circulation. Current ultrasound technology makes it possible to study blood flow noninvasively and to give new ... -
The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity
(Journal article; Peer reviewed, 2021)Variable number of tandem repeat (VNTR) sequences in the genome can have functional consequences that contribute to human disease. This is the case for the CEL gene, which is specifically expressed in pancreatic acinar ... -
A positive Real-Time Elastography (RTE) combined with a Prostate Cancer Gene 3 (PCA3) score above 35 convey a high probability of intermediate- or high-risk prostate cancer in patient admitted for primary prostate biopsy
(Peer reviewed; Journal article, 2016-07-08)Background: The standard of care in patients with suspected prostate cancer (PCa) is systematic prostate biopsies. This approach leads to unnecessary biopsies in patients without PCa and also to the detection of clinical ... -
Possible relation between maternal consumption of added sugar and sugar-sweetened beverages and birth weight - time trends in a population
(Peer reviewed; Journal article, 2012-10-24)Background: High birth weight (BW) is a risk factor for later obesity. In Norway, mean BW and proportion of large newborns increased from 1989 to 2000 and subsequently decreased to the 1989 level by 2010. The purpose of ...