Blar i Department of Clinical Medicine på tittel
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Perioperative interventions and postoperative outcomes
(Doctoral thesis, 2015-11-05)Background: Postoperative complications are frequent causes of postoperative mortality. Such complications may also lead to a prolonged period with decreased functional and cognitive status. Perioperative care is a factor ... -
Perioperative, short, and long-term mortality related to fixation in primary total hip arthroplasty: a study of 79,557 patients in the Norwegian Arthroplasty Register
(Peer reviewed; Journal article, 2019-12-13)Background and purpose — There are reports on perioperative deaths in cemented total hip arthroplasty (THA), and THA revisions are associated with increased mortality. We compared perioperative (intraoperatively or within ... -
Persistence of a pKPN3-like CTX-M-15-encoding IncFIIK plasmid in a Klebsiella pneumonia ST17 host during two years of intestinal colonization
(Peer reviewed; Journal article, 2015-03-04)Objectives. To characterize the CTX-M-15-encoding plasmid in a Klebsiella pneumoniae ST17 strain, responsible for an outbreak at a Norwegian neonatal intensive care unit and subsequent colonization of affected children for ... -
Persistent microembolic signals in the cerebral circulation on transcranial Doppler after intravenous sulfur hexafluoride microbubble infusion
(Peer reviewed; Journal article, 2019-11-20)BACKGROUND AND PURPOSE: Microembolic signals (MES) are detectable by transcranial Doppler monitoring and associated with increased risk of first or recurrent ischemic stroke. MES detection can also illuminate stroke etiology ... -
Personality traits predict job stress, depression and anxiety among junior physicians
(Peer reviewed; Journal article, 2013-11-09)Background: High levels of stress and deteriorating mental health among medical students are commonly reported. In Bergen, Norway, we explored the impact of personality traits measured early in their curriculum on stress ... -
Personalized estimation of one-year mortality risk after elective hip or knee arthroplasty for osteoarthritis.
(Journal article; Peer reviewed, 2020)Aims To develop and validate patient-centred algorithms that estimate individual risk of death over the first year after elective joint arthroplasty surgery for osteoarthritis. Methods A total of 763,213 hip and knee ... -
The Pharmacogenomics of Bipolar Disorder study (PGBD): Identification of genes for lithium response in a prospective sample
(Peer reviewed; Journal article, 2016-05-05)Background: Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization ... -
The pharmacokinetics, safety, and tolerability of mirabegron in children and adolescents with neurogenic detrusor overactivity or idiopathic overactive bladder and development of a population pharmacokinetic model-based pediatric dose estimation
(Peer reviewed; Journal article, 2019-10-22)Introduction: Mirabegron, a selective β3-adrenoreceptor agonist, is a well-established alternative to antimuscarinics in adults with overactive bladder (OAB) symptoms and is under development for use in pediatric patients. ... -
The phenotypic spectrum of polymerase gamma (POLG) disease from birth to late adulthood
(Doctoral thesis, 2020-09-25)Variants in POLG, the gene encoding the catalytic subunit of DNA-polymerase gamma (polγ), the enzyme that replicates and repairs the mitochondrial genome, are among the most common causes of inherited mitochondrial disease. ... -
Photopic full-field electroretinography and optical coherence tomography in type 1 diabetic retinopathy
(Peer reviewed; Journal article, 2015-07)Purpose: The purpose of this study was to evaluate the role of photopic full-field electroretinography (ERG) and retinal thickness measurements by spectral-domain optical coherence tomography (SD-OCT) in the assessment of ... -
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
(Peer reviewed; Journal article, 2011-11-01)Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies ... -
Physical models for simulation and reconstruction of human tissue deformation fields in dynamic MRI
(Peer reviewed; Journal article, 2016-10)Objective: Medical image registration can be formulated as a tissue deformation problem, where parameter estimation methods are used to obtain the inverse deformation. However, there is limited knowledge about the ability ... -
Physical training and exercise in myasthenia gravis
(Journal article; Peer reviewed, 2021)Myasthenia gravis is characterized by muscle weakness and fatigue. As sustained muscle use increases the weakness, the value of physical training programs has previously been questioned. This is a review to clarify the ... -
Physicians’ use of pain scale and treatment procedures among children and youth in emergency primary care - a cross sectional study
(Peer reviewed; Journal article, 2015-11-06)Background: Pain is a common symptom in children and youth attending casualty centres and emergency departments. The aim of this study was to acquire more knowledge about how pain in children is measured and handled by ... -
A pilot study of angiotensin converting enzyme (ACE) genotype and return of spontaneous circulation following out-of-hospital cardiac arrest
(Peer reviewed; Journal article, 2014-08-14)Objective: In the last few years the genetic influence on health and disease outcome has become more apparent. The ACE genotype appears to play a significant role in the pathophysiology of several disease processes. This ... -
A pilot study of hot-wire, ultrasonic and wedge-bellows spirometer inter- and intra-variability
(Peer reviewed; Journal article, 2017-10-10)Objective: The aim of this pilot study was to compare spirometric values obtained with different types of spirometers, spirometers of same type, and repeated measurements with the same spirometer in a pulmonary function ... -
A pilot study to determine whether combinations of objectively measured activity parameters can be used to differentiate between mixed states, mania, and bipolar depression
(Peer reviewed; Journal article, 2017-03-01)Background: Until recently, actigraphy studies in bipolar disorders focused on sleep rather than daytime activity in mania or depression, and have failed to analyse mixed episodes separately. Furthermore, even those studies ... -
Pilot testing of the first version of the European Association for Palliative Care basic dataset: A mixed methods study
(Peer reviewed; Journal article, 2019)Background: Inadequate description of palliative care cancer patients in research studies often leads to results having limited generalizability. To standardize the description of the sample, the European Association for ... -
Placental histology predicted adverse outcomes in extremely premature neonates in Norway-population-based study
(Journal article; Peer reviewed, 2021)Aim We evaluated the role of placental pathology in predicting adverse outcomes for neonates born extremely preterm (EPT) before 28 weeks of gestation. Methods This was a prospective observational study of 123 extremely ... -
Plasma 25 hydroxyvitamin D level and blood gene expression profiles: a cross-sectional study of the Norwegian Women and Cancer Post-genome Cohort
(Journal article; Peer reviewed, 2013)Background/Objectives: Vitamin D deficiency has been associated with increased risk of developing several diseases, but much is unknown about the molecular effects involved. Gene expression technology is increasingly being ...