Browsing Department of Clinical Medicine by Title
Now showing items 1515-1534 of 2080
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A Pellino-2 variant is associated with constitutive NLRP3 inflammasome activation in a family with ocular pterygium–digital keloid dysplasia
(Journal article; Peer reviewed, 2023)Ocular pterygium–digital keloid dysplasia (OPDKD) is a rare hereditary disease characterized by corneal ingrowth of vascularized conjunctival tissue early in life. Later, patients develop keloids on fingers and toes but ... -
Percutaneous cholecystostomy in acutecholecystitis; a retrospective analysis of a largeseries of 104 patients
(Peer reviewed; Journal article, 2015-03-08)Background: The purpose of this study was to evaluate the clinical course and possible benefit of a percutaneous cholecystostomy in patients with acute cholecystitis. Methods: Retrospective study of 104 patients with severe ... -
Percutaneous cholecystostomy – An option in selected patients with acute cholecystitis
(Journal article; Peer reviewed, 2020-05)While urgent percutaneous cholecystostomy (PC) was introduced as an alternative to acute surgical treatment for acute cholecystitis (AC), the current place of PC in the treatment algorithm for AC is challenged. We evaluate ... -
Perinatal Depression and Anxiety in Women with Multiple Sclerosis: A Population-Based Cohort Study
(Journal article; Peer reviewed, 2021)Objective: To assess the occurrence of perinatal depression and anxiety in women before and after diagnosis of multiple sclerosis (MS). Methods: 114,629 pregnant women were included in the Norwegian Mother, Father and Child ... -
Perioperative interventions and postoperative outcomes
(Doctoral thesis, 2015-11-05)Background: Postoperative complications are frequent causes of postoperative mortality. Such complications may also lead to a prolonged period with decreased functional and cognitive status. Perioperative care is a factor ... -
Perioperative, short, and long-term mortality related to fixation in primary total hip arthroplasty: a study of 79,557 patients in the Norwegian Arthroplasty Register
(Peer reviewed; Journal article, 2019-12-13)Background and purpose — There are reports on perioperative deaths in cemented total hip arthroplasty (THA), and THA revisions are associated with increased mortality. We compared perioperative (intraoperatively or within ... -
Persistence of a pKPN3-like CTX-M-15-encoding IncFIIK plasmid in a Klebsiella pneumonia ST17 host during two years of intestinal colonization
(Peer reviewed; Journal article, 2015-03-04)Objectives. To characterize the CTX-M-15-encoding plasmid in a Klebsiella pneumoniae ST17 strain, responsible for an outbreak at a Norwegian neonatal intensive care unit and subsequent colonization of affected children for ... -
Persistent microembolic signals in the cerebral circulation on transcranial Doppler after intravenous sulfur hexafluoride microbubble infusion
(Peer reviewed; Journal article, 2020)Background and purpose: Microembolic signals (MES) are detectable by transcranial Doppler monitoring and associated with increased risk of first or recurrent ischemic stroke. MES detection can also illuminate stroke etiology ... -
The personality profile of IPS employment specialists, and how it relates to job satisfaction: A longitudinal cohort study
(Journal article; Peer reviewed, 2022)The role of the Individual Placement and Support (IPS) employment specialist is a new type of occupation within mental healthcare. High turnover among employment specialists necessitates improvement in their recruitment ... -
Personality traits predict job stress, depression and anxiety among junior physicians
(Peer reviewed; Journal article, 2013-11-09)Background: High levels of stress and deteriorating mental health among medical students are commonly reported. In Bergen, Norway, we explored the impact of personality traits measured early in their curriculum on stress ... -
Personalized estimation of one-year mortality risk after elective hip or knee arthroplasty for osteoarthritis.
(Journal article; Peer reviewed, 2020)Aims To develop and validate patient-centred algorithms that estimate individual risk of death over the first year after elective joint arthroplasty surgery for osteoarthritis. Methods A total of 763,213 hip and knee ... -
The Pharmacogenomics of Bipolar Disorder study (PGBD): Identification of genes for lithium response in a prospective sample
(Peer reviewed; Journal article, 2016-05-05)Background: Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization ... -
Pharmacokinetics of epinephrine during cardiac arrest: A pilot study
(Journal article; Peer reviewed, 2023)Aim of the study: Epinephrine has been recommended for several decades for the treatment of cardiac arrest. However, although this potent medicament has a documented impact on the return of spontaneous circulation, it does ... -
The pharmacokinetics, safety, and tolerability of mirabegron in children and adolescents with neurogenic detrusor overactivity or idiopathic overactive bladder and development of a population pharmacokinetic model-based pediatric dose estimation
(Peer reviewed; Journal article, 2019-10-22)Introduction: Mirabegron, a selective β3-adrenoreceptor agonist, is a well-established alternative to antimuscarinics in adults with overactive bladder (OAB) symptoms and is under development for use in pediatric patients. ... -
Pharmacological evaluation of the effects of enzymatically liberated fish oil on eosinophilic inflammation in animal models
(Journal article; Peer reviewed, 2022)The inappropriate activation of eosinophils is a well-recognized driver of various human inflammatory diseases including asthma, chronic rhinitis, and various gastrointestinal diseases, including eosinophilic esophagitis. ... -
Phenotypic spectrum and clinical course of single large-scale mitochondrial DNA deletion disease in the paediatric population: a multicentre study
(Journal article; Peer reviewed, 2023)Background: Large-scale mitochondrial DNA deletions (LMD) are a common genetic cause of mitochondrial disease and give rise to a wide range of clinical features. Lack of longitudinal data means the natural history remains ... -
The phenotypic spectrum of polymerase gamma (POLG) disease from birth to late adulthood
(Doctoral thesis, 2020-09-25)Variants in POLG, the gene encoding the catalytic subunit of DNA-polymerase gamma (polγ), the enzyme that replicates and repairs the mitochondrial genome, are among the most common causes of inherited mitochondrial disease. ... -
Photopic full-field electroretinography and optical coherence tomography in type 1 diabetic retinopathy
(Peer reviewed; Journal article, 2015-07)Purpose: The purpose of this study was to evaluate the role of photopic full-field electroretinography (ERG) and retinal thickness measurements by spectral-domain optical coherence tomography (SD-OCT) in the assessment of ... -
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
(Peer reviewed; Journal article, 2011-11-01)Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies ... -
Physical models for simulation and reconstruction of human tissue deformation fields in dynamic MRI
(Peer reviewed; Journal article, 2016-10)Objective: Medical image registration can be formulated as a tissue deformation problem, where parameter estimation methods are used to obtain the inverse deformation. However, there is limited knowledge about the ability ...