Blar i Department of Clinical Medicine på tittel
Viser treff 1535-1554 av 2064
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Plasma Concentrations of Extracellular DNA in Acute Kidney Injury
(Journal article; Peer reviewed, 2020)Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Tissue injury has been linked to an increase in the concentrations of extracellular DNA (ecDNA) in plasma. A rapid turnover ... -
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study
(Peer reviewed; Journal article, 2013-02)Choline and betaine are nutrients involved in one-carbon metabolism. Choline is essential for neurodevelopment and brain function. We studied the associations between cognitive function and plasma concentrations of free ... -
Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study
(Journal article; Peer reviewed, 2023)Background: Inflammation is proposed to be involved in the pathogenesis of poststroke cognitive impairment. The aim of this study was to investigate associations between concentrations of systemic inflammatory biomarkers ... -
Plasma levels of guanylins are reduced in patients with Crohn’s disease
(Journal article; Peer reviewed, 2020)Background: Guanylin (GN) and uroguanylin (UGN) are endogenous ligands for the intestinal receptor guanylate cyclase C (GC-C), an important regulator of intestinal fluid homeostasis. Gene expression and protein levels of ... -
Plasma Retinol and Cardiovascular Disease Mortality in the BECAC Population
(Master thesis, 2014-05-15)Background: Observational studies have suggested a possible link between vitamin A and cardiovascular disease mortality risk. However, randomized supplementation trials have failed to show improvement in survival. There ... -
Plasma unmetabolized folic acid in pregnancy and risk of autistic traits and language impairment in antiseizure medication-exposed children of women with epilepsy
(Journal article; Peer reviewed, 2022)Background: Fetal exposure to unmetabolized folic acid (UMFA) during pregnancy may be associated with adverse neurodevelopment. Antiseizure medication (ASM) may interact with folate metabolism. Women with epilepsy using ... -
Pneumomediastinum etter sternalpunksjon
(Journal article; Peer reviewed, 2021) -
PNKP Mutations Identified by Whole-Exome Sequencing in a Norwegian Patient with Sporadic Ataxia and Edema
(Journal article, 2017-02)We identified PNKP mutations in a Norwegian woman with AOA. This patient had the typical findings with cognitive dysfunction, peripheral neuropathy, cerebellar dysarthria, horizontal nystagmus, oculomotor apraxia, and ... -
Podocan and Adverse Clinical Outcome in Patients Admitted With Suspected Acute Coronary Syndromes
(Journal article; Peer reviewed, 2022)Background: Markers of bone and extracellular matrix (ECM) remodeling may be associated with adverse outcomes in atherosclerotic cardiovascular disease. Podocan is a newly discovered ECM glycoprotein, previously not studied ... -
Point-of-care ultrasound of the gastrointestinal tract
(Journal article; Peer reviewed, 2023)The widespread use of portable ultrasound scanners has promoted the concept of point of care ultrasound (POCUS), namely “ultrasound performed bedside and interpreted directly by the clinician.” The purpose of this short ... -
POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia
(Journal article; Peer reviewed, 2023)Diseases caused by POLG mutations are the most common form of mitochondrial diseases and associated with phenotypes of varying severity. Clinical studies have shown that patients with compound heterozygous POLG mutations ... -
POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition
(Journal article; Peer reviewed, 2022)We showed previously that POLG mutations cause major changes in mitochondrial function, including loss of mitochondrial respiratory chain (MRC) complex I, mitochondrial DNA (mtDNA) depletion and an abnormal NAD+/NADH ratio ... -
Polio and post-polio syndrome in non-Western immigrants: A new challenge for the healthcare system in Norway
(Peer reviewed; Journal article, 2019)Objective: To explore the health situation and identify specific health challenges in non-Western immigrants with polio in Norway, by comparing their status with Western immigrants with polio and native Norwegians with ... -
Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix
(Peer reviewed; Journal article, 2019)Several proteins linked to familial Parkinson disease have been associated with mitochondrial (dys-)function and have been described to reside within mitochondria. The putative mitochondrial and sub-mitochondrial localization ... -
Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
(Journal article; Peer reviewed, 2021)Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship ... -
Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users
(Peer reviewed; Journal article, 2012-10-27)Introduction: Mammographic density (MD) is one of the strongest known breast cancer risk factors. Estrogen and progestin therapy (EPT) has been associated with increases in MD. Dense breast tissue is characterized by ... -
Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort : a case control study
(Peer reviewed; Journal article, 2006-03-16)Background: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in ... -
Polyvinylpyrrolidone deposition disease : The role of pathology in understanding disease and death in persons with opioid addiction and intravenous drug use
(Doctoral thesis, 2023-10-13)Bakgrunn og målsetting: Polymeren polyvinylpyrrolidon (PVP) er mye brukt som tilsetningsstoff i legemidler. PVP med høy molekylvekt kan ikke utskilles via nyrene og vil derfor opphopes i kroppens vev dersom det administreres ... -
Polyvinylpyrrolidone deposition disease in patients with intravenous opioid use: a case series
(Journal article; Peer reviewed, 2021)The polymer polyvinylpyrrolidone (PVP) is an excipient widely used in prescription drugs. Depending on the molecular weight (MW), parenterally administered PVP may accumulate in various tissues. Consequently, moderate and ... -
Poor Sleep in Patients with Multiple Sclerosis
(Peer reviewed; Journal article, 2012-11-14)Background: Poor sleep is a frequent symptom in patients with multiple sclerosis (MS). Sleep may be influenced by MS-related symptoms and adverse effects from immunotherapy and symptomatic medications. We aimed to study ...