Blar i Department of Clinical Science på tittel
Viser treff 965-984 av 2297
-
High mobility group box 1 and a network of other biomolecules influence fatigue in patients with Crohn’s disease
(Journal article; Peer reviewed, 2023)Background Fatigue is common in patients with chronic inflammatory and autoimmune diseases, often with a severe impact on the patient’s daily life. From a biological point of view, fatigue can be regarded as an element ... -
High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections
(Peer reviewed; Journal article, 2018-11-23)Background The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces ... -
High number of hypoglycaemic episodes identified by CGM among home-dwelling older people with diabetes: an observational study in Norway
(Journal article; Peer reviewed, 2023)Background A scoping review from 2021 identified a lack of studies on the incidence, prevention and management of hypoglycaemia in home-dwelling older people with diabetes. The aim of this study was to investigate the ... -
High prevalence of faecal carriage of ESBL-producing enterobacteriaceae among children in Dar es Salaam, Tanzania
(Peer reviewed; Journal article, 2016-12-09)Background: Faecal carriage of ESBL-producing bacteria is a potential risk for transmission and infection. Little is known about faecal carriage of antibiotic resistance in Tanzania. This study aimed to investigate the ... -
High prevalence of fecal carriage of extended spectrum β-lactamase-producing enterobacteriaceae among newly HIV-diagnosed adults in a community setting in Tanzania
(Journal article; Peer reviewed, 2020)Colonization in HIV-infected populations with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) is particularly worrisome in low-income settings. This study describes the prevalence of ESBL-PE carriage ... -
High prevalence of humoral and cellular immunity to influenza viruses in pre-school children living in Addis Ababa, Ethiopia
(Peer reviewed; Journal article, 2017-01)Background. Influenza in children who reside in tropical and subtropical regions has until recently been regarded as insignificant. However, new evidence suggests that it significantly impacts hospitalization and promotes ... -
High prevalence of orthostatic hypotension in mild dementia
(Peer reviewed; Journal article, 2009-11)Background/Aims: Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia. Methods: Patients with mild ... -
High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function
(Peer reviewed; Journal article, 2017)Purpose: PTEN is an important tumor suppressor in breast cancer. Here, we examined the prognostic and predictive value of PTEN and PTEN pseudogene (PTENP1) gene expression in patients with locally advanced breast cancer ... -
High rate of antimicrobial resistance and multiple mutations in the dihydrofolate reductase gene among Streptococcus pneumoniae isolated from HIV-infected adults in a community setting in Tanzania
(Journal article; Peer reviewed, 2020)Objectives: The aim of this study was to characterize molecular mechanisms of resistance to trimethoprim and other antibiotics in Streptococcus pneumoniae isolates from HIV-infected adults in Dar es Salaam, Tanzania. Methods: ... -
High visceral fat percentage is associated with poor outcome in endometrial cancer
(Peer reviewed; Journal article, 2017-10-19)Despite evidence of increased endometrial cancer (EC) risk in obese women, the impact of obesity on clinical and histological phenotype is poorly understood. This study explored abdominal fat volumes and fat distribution ... -
High-Grade Cervical Intraepithelial Neoplasia (CIN) Associates with Increased Proliferation and Attenuated Immune Signaling
(Journal article; Peer reviewed, 2021)Implementation of high-risk human papilloma virus (HPV) screening and the increasing proportion of HPV vaccinated women in the screening program will reduce the percentage of HPV positive women with oncogenic potential. ... -
High-intensity Interval Training after Percutaneous Coronary Intervention. A randomized controlled study evaluating the effect of exercise training on late luminal loss with relationship to inflammation and endothelial function
(Doctoral thesis, 2010-10-22)Introduction: In spite of consistent scientific documentation of the beneficial effects of exercise training programs in coronary artery disease (CAD), exercise training is a remarkably underutilized (1) and probably also ... -
High-Intensity Interval Training in Patients with Heart Failure with Reduced Ejection Fraction
(Peer reviewed; Journal article, 2017-02)Background: Small studies have suggested that high-intensity interval training (HIIT) is superior to moderate continuous training (MCT) in reversing cardiac remodeling and increasing aerobic capacity in patients with heart ... -
High-normal blood pressure in midlife is a stronger risk factor for incident hypertension 26 years later in women than men: the Hordaland Health Study
(Journal article; Peer reviewed, 2023)Purpose To identify modifiable risk factors in early midlife associated with incident hypertension 26 years later in women and men. Materials and methods We used data from 1025 women and 703 men in the community-based ... -
High-Sensitivity Cardiac Troponin I and T Response Following Strenuous Activity is Attenuated by Smokeless Tobacco: NEEDED (North Sea Race Endurance Exercise Study) 2014
(Journal article; Peer reviewed, 2020)Background Use of snus, a smokeless tobacco product, is increasing in Scandinavia. Strenuous physical activity is associated with an acute increase in high‐sensitivity cardiac troponin (swhs‐cTn) concentrations. Current ... -
Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease
(Journal article; Peer reviewed, 2023)Introduction: The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the N-methyl-D-aspartate receptor, a possible ... -
Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly
(Peer reviewed; Journal article, 2011-02-16)Background: The HIV-1 p6 Gag protein regulates the final abscission step of nascent virions from the cell membrane by the action of two late assembly (L-) domains. Although p6 is located within one of the most polymorphic ... -
Highly contiguous genomes of human clinical isolates of Giardia duodenalis reveal assemblage-and sub-assemblage-specific presence–absence variation in protein-coding genes
(Journal article; Peer reviewed, 2023)Giardia duodenalis (syn. G. intestinalis, G. lamblia) is a widespread gastrointestinal protozoan parasite with debated taxonomic status. Currently, eight distinct genetic sub-groups, termed assemblages A–H, are defined ... -
Histologic healing and factors associated with complete remission following conventional treatment in ulcerative colitis
(Journal article; Peer reviewed, 2022)Background: Endoscopic and histological activity scores in ulcerative colitis (UC) are associated with clinical outcomes and have become important targets of clinical trials. However, these endpoints have been scarcely ... -
Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents
(Peer reviewed; Journal article, 2013-07-30)Several new therapeutic strategies are now considered for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation through inhibition of histone deacetylases ...