Browsing Department of Biomedicine by Title
Now showing items 463-482 of 710
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New lessons from an “old” drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia
(Doctoral thesis, 2007-12-18)Anthracyclines have been first line drugs for more than 3 decades in the treatment of acute myelogenous leukemia (AML). Even though the mechanism of action of anthracyclines has been extensively studied over the years, ... -
A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology
(Peer reviewed; Journal article, 2015-11-24)Changes in mitochondrial amount and shape are intimately linked to maintenance of cell homeostasis via adaptation of vital functions. Here, we developed a new live-cell reporter strategy to simultaneously monitor mitochondrial ... -
A New Look at the Functional Organization of the Golgi Ribbon
(Peer reviewed; Journal article, 2019-08-21)A characteristic feature of vertebrate cells is a Golgi ribbon consisting of multiple cisternal stacks connected into a single-copy organelle next to the centrosome. Despite numerous studies, the mechanisms that link the ... -
A New Method for Isolation of Interstitial Fluid from Human Solid Tumors Applied to Proteomic Analysis of Ovarian Carcinoma Tissue
(Peer reviewed; Journal article, 2011-04-26)Major efforts have been invested in the identification of cancer biomarkers in plasma, but the extraordinary dynamic range in protein composition, and the dilution of disease specific proteins make discovery in plasma ... -
New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells
(Journal article, 2021)Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and ... -
New tools to enhance the detection of post-translational modifications: Development and application of a mass spectrometry-based proteomic software and of specific antibodies detecting propionylated lysines
(Master thesis, 2009-08-02)Mass spectrometry based proteomics has evolved into a powerful tool in characterising proteins and their respective function in the cell. A proteins cellular localisation, concentration and activity is regulated by several ... -
NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival
(Peer reviewed; Journal article, 2014-12)Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms ... -
NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo
(Peer reviewed; Journal article, 2014-01-13)microRNAs (miRNAs) are major regulators of protein synthesis in the brain. A major goal is to identify changes in miRNA expression underlying protein synthesis-dependent forms of synaptic plasticity such as long-term ... -
No Protection against DSS-induced Colitis by Short-term Pretreatment with Seal or Fish Oils in Rats
(Peer reviewed; Journal article, 2007-04-30)Background: Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have modulating effects in several chronic infl ammatory conditions. The aim of the present study was to test whether prior short-term dietary supplementation ... -
Normalized gradient fields for nonlinear motion correction of DCE-MRI time series
(Peer reviewed; Journal article, 2014-04)Dynamic MR image recordings (DCE-MRI) of moving organs using bolus injections create two differenttypes of dynamics in the images: (i) spatial motion artifacts due to patient movements, breathing andphysiological pulsations ... -
Novel clearance of muscle proteins by muscle cells
(Journal article; Peer reviewed, 2020)Blood levels of cardiac troponins (cTn) and myoglobin are analysed when myocardial infarction (MI) is suspected. Here we describe a novel clearance mechanism for muscle proteins by muscle cells. The complete plasma clearance ... -
A novel GFP nude rat model to investigate tumor-stroma interactions
(Peer reviewed; Journal article, 2014-12-21)Backgroud: A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ... -
Novel Insights into Integrin α11 Expression and Function
(Doctoral thesis, 2020-01-31)Integrins are a major group of cell surface receptors, which link the extracellular matrix with the cell cytoskeleton. They are heterodimeric proteins consisting of non- covalently bound α- and β-subunits. By regulating ... -
Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment
(Peer reviewed; Journal article, 2018-02)Objective Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric condition. By exploiting the reported relationship between ADHD and educational attainment (EA), we aimed to improve ... -
Novel method for isolating untouched rat natural killer cells with higher purity compared with positive selection and fluorescenceactivated cell sorting
(Peer reviewed; Journal article, 2010-11)Natural killer (NK) cells are important effectors of both innate and adaptive immune responses. Although human and mouse NK cells are extensively characterized, much less is known about the rat cells, partly because of the ... -
Novel microscopy-based screening method reveals regulators of contact-dependent intercellular transfer
(Peer reviewed; Journal article, 2015-08-14)Contact-dependent intercellular transfer (codeIT) of cellular constituents can have functional consequences for recipient cells, such as enhanced survival and drug resistance. Pathogenic viruses, prions and bacteria can ... -
A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly
(Peer reviewed; Journal article, 2019-06-07)Background N-terminal acetylation is a common protein modification in human cells and is catalysed by N-terminal acetyltransferases (NATs), mostly cotranslationally. The NAA10-NAA15 (NatA) protein complex is the major NAT, ... -
A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines
(Peer reviewed; Journal article, 2015-09-08)To facilitate efficient drug delivery to tumor tissue, several nanomaterials have been designed, with combined diagnostic and therapeutic properties. In this work, we carried out fundamental in vitro and in vivo experiments ... -
Novel Points of Attack for Targeted Cancer Therapy
(Peer reviewed; Journal article, 2015-01)New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ... -
Novel Points of Attack for Targeted Cancer Therapy
(Peer reviewed; Journal article, 2014-10-30)New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...