Blar i Department of Biomedicine på tittel

Viser treff 61-80 av 773

    • B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion 

      Breivik, Lars Ertesvåg; Jensen, Andreas; Guvåg, Steinar; Aarnes, Eva-Katrine; Aspevik, Anne; Helgeland, Erik; Hovland, Siren; Brattelid, Trond; Jonassen, Anne K. (Peer reviewed; Journal article, 2015-04)
      Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ...

    • The balance between NAD+ biosynthesis and consumption in ageing 

      Strømland, Øyvind; Diab, Joseph; Ferrario, Eugenio; Sverkeli, Lars Jansen; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several ...

    • BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma 

      Wang, Jiwei; Chen, Anbin; Xue, Zhiwei; Liu, Junzhi; He, Ying; Liu, Guowei; Zhao, Zhimin; Li, Wenjie; Zhang, Qing; Chen, Anjing; Wang, Jian; Li, Xingang; Wang, Xinyu; Huang, Bin (Journal article; Peer reviewed, 2023)
      There is an urgent need for novel diagnostic and therapeutic strategies for patients with Glioblastoma multiforme (GBM). Previous studies have shown that BCL2 like 13 (BCL2L13) is a member of the BCL2 family regulating ...

    • BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis 

      Kuipers, Sjoukje; Trentani, Andrea; Tiron, Adrian; Mao, Xiaosong; Kuhl, Dietmar; Bramham, Clive R. (Peer reviewed; Journal article, 2016-02-18)
      Adult neurogenesis in the hippocampus is a remarkable phenomenon involved in various aspects of learning and memory as well as disease pathophysiology. Brain-derived neurotrophic factor (BDNF) represents a major player in ...

    • The Benefit of Large Neutral Amino Acid Supplementation to a Liberalized Phenylalanine-Restricted Diet in Adult Phenylketonuria Patients: Evidence from Adult Pah-Enu2 Mice 

      Van Vliet, Danique; van der Goot, Els; van Ginkel, Wiggert G; van Faassen, Martijn H J R; de Blaauw, Pim; Kema, Ido P.; Martinez, Aurora; Heiner-Fokkema, M Rebecca; van der Zee, Eddy A; van Spronsen, Francjan J. (Peer reviewed; Journal article, 2019-09-19)
      Many phenylketonuria (PKU) patients cannot adhere to the severe dietary restrictions as advised by the European PKU guidelines, which can be accompanied by aggravated neuropsychological impairments that, at least in part, ...

    • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Peer reviewed; Journal article, 2015-01)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...

    • Bi-specific tenascin-C and fibronectin targeted peptide for solid tumor delivery 

      Lingasamy, Prakash; Tobi, Allan; Haugas, Maarja; Hunt, Hedi; Paiste, Paarn; Asser, Toomas; Ratsep, Tonu; Kotamraju, Venkata Ramana; Bjerkvig, Rolf; Teesalu, Tambet (Peer reviewed; Journal article, 2019)
      Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of ...

    • Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications 

      Chelban, Viorica; Aksnes, Henriette; Maroofian, Reza; LaMonica, Lauren C.; Seabra, Luis; Siggervåg, Anette; Devic, Perrine; Shamseldin, Hanan E.; Vandrovcova, Jana; Murphy, David; Richard, Anne-Claire; Quenez, Olivier; Bonnevalle, Antoine; Zanetti, M Natalia; Kaiyrzhanov, Rauan; Salpietro, Vincenzo; Efthymiou, Stephanie; Schottlaender, Lucia V.; Morsy, Heba; Scardamaglia, Annarita; Tariq, Ambreen; Pagnamenta, Alistair T.; Pennavaria, Ajia Rae; Krogstad, Liv Svenningsson; Bekkelund, Åse Karine; Caiella, Alessia; Glomnes, Nina; Brønstad, Kirsten Marie; Tury, Sandrine; Moreno De Luca, Andrés; Boland-Auge, Anne; Olaso, Robert; Deleuze, Jean-François; Anheim, Mathieu; Cretin, Benjamin; Vona, Barbara; Alajlan, Fahad; Abdulwahab, Firdous; Battini, Jean-Luc; İpek, Rojan; Bauer, Peter; Zifarelli, Giovanni; Gungor, Serdal; Kurul, Semra Hiz; Lochmuller, Hanns; Da'as, Sahar I.; Fakhro, Khalid A.; Gómez-Pascual, Alicia; Botía, Juan A.; Wood, Nicholas W.; Horvath, Rita; Ernst, Andreas M.; Rothman, James E.; McEntagart, Meriel; Crow, Yanick J.; Alkuraya, Fowzan S.; Nicolas, Gaël; Arnesen, Thomas; Houlden, Henry (Journal article; Peer reviewed, 2024)
      Primary familial brain calcification (PFBC) is characterized by calcium deposition in the brain, causing progressive movement disorders, psychiatric symptoms, and cognitive decline. PFBC is a heterogeneous disorder currently ...

    • Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders 

      Zhang, Hongyu; Bramham, Clive R. (Journal article; Peer reviewed, 2020-07-10)
      AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal ...

    • Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants 

      Korbmacher, Max; Gurholt, Tiril Pedersen; de Lange, Ann Marie; Van der meer, Dennis; Beck, Dani; Eikefjord, Eli Nina; Lundervold, Arvid; Andreassen, Ole; Maximov, Ivan (Journal article; Peer reviewed, 2023)
      Brain age refers to age predicted by brain features. Brain age has previously been associated with various health and disease outcomes and suggested as a potential biomarker of general health. Few previous studies have ...

    • Biochemical analysis of novel NAA10 variants suggests distinct pathogenic mechanisms involving impaired protein N‑terminal acetylation 

      McTiernan, Nina; Tranebjærg, Lisbeth; Bjørheim, Anna Steensen; Hogue, Jacob S.; Wilson, William G.; Schmidt, Berkley; Boerrigter, Melissa M.; Nybo, Maja L.; Smeland, Marie; Tümer, Zeynep; Arnesen, Thomas (Journal article; Peer reviewed, 2022)
      NAA10 is the catalytic subunit of the N-terminal acetyltransferase complex, NatA, which is responsible for N-terminal acetylation of nearly half the human proteome. Since 2011, at least 21 different NAA10 missense variants ...

    • Biochemical and biophysical characterisation of HMBS variants associated with acute intermittent porphyria 

      Sæter, Marthe Christie (Master thesis, 2022-06-01)

    • BioContainers: An open-source and community-driven framework for software standardization 

      Leprevost, Felipe da Veiga; Grüning, Björn A.; Alves Aflitos, Saulo; Röst, Hannes L.; Uszkoreit, Julian; Barsnes, Harald; Vaudel, Marc; Moreno, Pablo; Gatto, Laurent; Weber, Jonas; Bai, Mingze; Jimenez, Rafael C.; Sachsenberg, Timo; Pfeuffer, Julianus; Vera Alvarez, Roberto; Griss, Johannes; Nesvizhskii, Alexey I.; Perez-Riverol, Yasset (Peer reviewed; Journal article, 2017-03-30)
      Motivation BioContainers (biocontainers.pro) is an open-source and community-driven framework which provides platform independent executable environments for bioinformatics software. BioContainers allows labs of all sizes ...

    • Biological responses of dental pulp stem cells to surfaces modified by collagen 1 and fibronectin 

      Omer, Abedelfattah Atif Taher (Master thesis, 2014-01-18)
      Collagen 1 and fibronectin are extracellular matrix proteins that contribute in cell activity and involve in regulating dental pulp stem cells. The purpose of this in vitro study was to investigate the effect of collagen ...

    • Biomedical Image Processing in the Study of Living Cells 

      Hodneland, Erlend (Doctoral thesis, 2008-12-09)

    • Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers 

      Makumire, Stanley; Zininga, Tawanda; Vahokoski, Juha; Kursula, Inari; Shonhai, Addmore (Journal article; Peer reviewed, 2020)
      Plasmodium falciparum causes the most lethal form of malaria. The cooperation of heat shock protein (Hsp) 70 and 90 is thought to facilitate folding of select group of cellular proteins that are crucial for cyto-protection ...

    • Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway 

      Rahman, Mohummad Aminur; Engelsen, Agnete; Sarowar, Shahin; Bindesbøll, Christian; Birkeland, Even; Goplen, Dorota; Lotsberg, Maria Lie; Knappskog, Stian; Simonsen, Anne Gjøen; Enger, Martha (Journal article; Peer reviewed, 2022)
      Introduction: Glioblastoma (GBM) is invariably resistant to temozolomide (TMZ) chemotherapy. Inhibiting the proteasomal pathway is an emerging strategy to accumulate damaged proteins and inhibit their lysosomal degradation. ...

    • Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival 

      Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn; Engelsen, Agnete; Bindesbøll, Christian; Sarowar, Shahin; Bahador, Marzieh; Bifulco, Ersilia; Goplen, Dorota; Waha, Andreas; Lie, Stein Atle; Gjertsen, Bjørn Tore; Selheim, Frode; Enger, Per Øyvind; Simonsen, Anne; Enger, Martha Chekenya (Peer reviewed; Journal article, 2019-08-15)
      Background Resistance to temozolomide (TMZ) is due in part to enhanced DNA repair mediated by high expression of O6-methyl guanine DNA methyltransferase (MGMT) that is often characterised by unmethylated promoter. Here, ...

    • Brain Computer Interface - Neurophysiology and Experimental Examples 

      Leidland, Einar (Master thesis, 2011-07-20)
      The last century has seen an incredible leap in human medicine, which has led to an increased life expectancy spanning over all age groups. Despite this development of modern medicine some patient groups do not have any ...

    • Brain‐wide associations between white matter and age highlight the role of fornix microstructure in brain ageing 

      Korbmacher, Max; de Lange, Ann-Marie; van der Meer, Dennis; Beck, Dani; Eikefjord, Eli Nina; Lundervold, Arvid; Andreassen, Ole; Westlye, Lars Tjelta; Maximov, Ivan (Journal article; Peer reviewed, 2023)
      Unveiling the details of white matter (WM) maturation throughout ageing is a fundamental question for understanding the ageing brain. In an extensive comparison of brain age predictions and age-associations of WM features ...