Blar i Department of Biomedicine på tittel
Viser treff 51-70 av 596
-
B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion
(Peer reviewed; Journal article, 2015-04)Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ... -
The balance between NAD+ biosynthesis and consumption in ageing
(Journal article; Peer reviewed, 2021)Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several ... -
BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis
(Peer reviewed; Journal article, 2016-02-18)Adult neurogenesis in the hippocampus is a remarkable phenomenon involved in various aspects of learning and memory as well as disease pathophysiology. Brain-derived neurotrophic factor (BDNF) represents a major player in ... -
The Benefit of Large Neutral Amino Acid Supplementation to a Liberalized Phenylalanine-Restricted Diet in Adult Phenylketonuria Patients: Evidence from Adult Pah-Enu2 Mice
(Peer reviewed; Journal article, 2019-09-19)Many phenylketonuria (PKU) patients cannot adhere to the severe dietary restrictions as advised by the European PKU guidelines, which can be accompanied by aggravated neuropsychological impairments that, at least in part, ... -
Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas
(Peer reviewed; Journal article, 2015-01)Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ... -
Bi-specific tenascin-C and fibronectin targeted peptide for solid tumor delivery
(Peer reviewed; Journal article, 2019)Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of ... -
Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders
(Journal article; Peer reviewed, 2020-07-10)AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal ... -
BioContainers: An open-source and community-driven framework for software standardization
(Peer reviewed; Journal article, 2017-03-30)Motivation BioContainers (biocontainers.pro) is an open-source and community-driven framework which provides platform independent executable environments for bioinformatics software. BioContainers allows labs of all sizes ... -
Biological responses of dental pulp stem cells to surfaces modified by collagen 1 and fibronectin
(Master thesis, 2014-01-18)Collagen 1 and fibronectin are extracellular matrix proteins that contribute in cell activity and involve in regulating dental pulp stem cells. The purpose of this in vitro study was to investigate the effect of collagen ... -
Biomedical Image Processing in the Study of Living Cells
(Doctoral thesis, 2008-12-09) -
Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers
(Journal article; Peer reviewed, 2020)Plasmodium falciparum causes the most lethal form of malaria. The cooperation of heat shock protein (Hsp) 70 and 90 is thought to facilitate folding of select group of cellular proteins that are crucial for cyto-protection ... -
Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival
(Peer reviewed; Journal article, 2019-08-15)Background Resistance to temozolomide (TMZ) is due in part to enhanced DNA repair mediated by high expression of O6-methyl guanine DNA methyltransferase (MGMT) that is often characterised by unmethylated promoter. Here, ... -
Brain Computer Interface - Neurophysiology and Experimental Examples
(Master thesis, 2011-07-20)The last century has seen an incredible leap in human medicine, which has led to an increased life expectancy spanning over all age groups. Despite this development of modern medicine some patient groups do not have any ... -
C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer
(Journal article; Peer reviewed, 2022)Epidemiological studies have established a positive association between obesity and the incidence of postmenopausal breast cancer. Moreover, it is known that obesity promotes stem cell-like properties of breast cancer ... -
Cabozantinib is effective in melanoma brain metastasis cell lines and affects key signaling pathways
(Journal article; Peer reviewed, 2021-11-14)Melanomas have a high potential to metastasize to the brain. Recent advances in targeted therapies and immunotherapies have changed the therapeutical landscape of extracranial melanomas. However, few patients with melanoma ... -
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
(Peer reviewed; Journal article, 2009-11-13)Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ... -
Cancer stem cells as mediators of treatment resistance in brain tumors: Status and controversies
(Peer reviewed; Journal article, 2007-11)Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumorrelated mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and ... -
Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins
(Peer reviewed; Journal article, 2019)The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM) macromolecules filled with a collection of cells including cancer-associated fibroblasts (CAFs), blood vessel associated smooth muscle ... -
A candidate gene investigation of methylphenidate response in adult attention-deficit/hyperactivity disorder patients: results from a naturalistic study
(Peer reviewed; Journal article, 2016-08)Attention-deficit/hyperactivity disorder (ADHD) is a common childhood onset neuropsychiatric disorder with a complex and heterogeneous symptomatology. Persistence of ADHD symptoms into adulthood is common. Methylphenidate ... -
Capacitance measurement of dendritic exocytosis in an electrically coupled inhibitory retinal interneuron: an experimental and computational study
(Peer reviewed; Journal article, 2019-08-04)Exocytotic release of neurotransmitter can be quantified by electrophysiological recording from postsynaptic neurons. Alternatively, fusion of synaptic vesicles with the cell membrane can be measured as increased capacitance ...