Browsing Department of Biomedicine by Title
Now showing items 432-451 of 530
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SearchGUI: a highly adaptable common interface for proteomics search and de novo engines
(Peer reviewed; Journal article, 2018)Mass-spectrometry-based proteomics has become the standard approach for identifying and quantifying proteins. A vital step consists of analyzing experimentally generated mass spectra to identify the underlying peptide ... -
Segmentation-Driven Image Registration-Application to 4D DCE-MRI Recordings of the Moving Kidneys
(Peer reviewed; Journal article, 2014-04-01)Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of the kidneys requires proper motion correction and segmentation to enable an estimation of glomerular filtration rate through pharmacokinetic modeling. ... -
Semaphorin 3A and Class 4 Semaphorins in Tooth Innervation and Development
(Doctoral thesis, 2014-10-10)Background: Dental trigeminal axon elongation, navigation and patterning occur in a controlled manner that is intimately linked to tooth shape formation and cell differentiation. Development of tooth results from sequential ... -
Semi-automatic 3D morphological reconstruction of neurons with densely branching morphology: Application to retinal AII amacrine cells imaged with multi-photon excitation microscopy
(Peer reviewed; Journal article, 2017-03)Background: Accurate reconstruction of the morphology of single neurons is important for morphometric studies and for developing compartmental models. However, manual morphological reconstruction can be extremely time-consuming ... -
Sensing foul AIRE: Investigating possible reporter genes for AIRE mutations
(Master thesis, 2018-06-29)The autoimmune regulator protein, known as AIRE, is a potent transcriptional regulator active in medullary thymic epithelial cells (mTECs) of the thymus, where it is able to switch on the expression of thousands of genes ... -
Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study
(Journal article; Peer reviewed, 2020)Background Glioblastoma (GBM) is an aggressive malignant brain tumor where median survival is approximately 15 months after best available multimodal treatment. Recurrence is inevitable, largely due to O6 methylguanine ... -
Serine 19 phosphorylation and 14‐3‐3 binding regulate phosphorylation and dephosphorylation of tyrosine hydroxylase on serine 31 and serine 40
(Peer reviewed; Journal article, 2019-09-17)Multisite phosphorylation and structural flexibility allow for complex regulation of proteins through cellular signaling. Tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, is regulated by multiple neuronal ... -
Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case–control study
(Peer reviewed; Journal article, 2015-11-05)Background: The essential amino acid tryptophan is catabolised mainly through the kynurenine pathway. Altered circulating levels of kynurenines have been reported in chronic inflammatory conditions and in several ... -
Severe traumatic brain injury in Norway: Impact of age on outcome
(Peer reviewed; Journal article, 2013-04-23)Objective: The aim of this study was to investigate the influence of age on mortality and 3-month outcome in a Norwegian cohort of patients with severe traumatic brain injury (TBI). Methods: Norwegian residents ≥ 16 years ... -
Sex differences in parent–offspring recurrence of attention-deficit/hyperactivity disorder
(Journal article; Peer reviewed, 2020)Background Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder sharing genetic risk factors with other common psychiatric disorders. However, intergenerational recurrence ... -
Shanks - multidomain molecular scaffolds of the postsynaptic density
(Peer reviewed; Journal article, 2019-03-06)The postsynaptic density (PSD) is a protein-rich assembly below the postsynaptic membrane, formed of large scaffolding proteins. These proteins carry a combination of protein interaction domains, which may interact with ... -
Shedding light on black boxes in protein identification
(Peer reviewed; Journal article, 2014-05)Performing a well thought-out proteomics data analysis can be a daunting task, especially for newcomers to the field. Even researchers experienced in the proteomics field can find it challenging to follow existing publication ... -
Short-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel disease
(Peer reviewed; Journal article, 2006-03-20)Background: A high dietary intake of n-6 compared to n-3 fatty acids (FAs) may promote the production of pro-inflammatory eicosanoids and cytokines. In two recent studies, short-term (10- day) duodenal administration of ... -
A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons
(Peer reviewed; Journal article, 2019-03)Background Primary neuronal cultures are widely used to elucidate fundamental aspects of neuronal anatomy, physiology, cell biology, and neuronal dysfunction in animal models of disease. However, preparation of primary ... -
Single cell analysis of signal transduction in hematopoietic stem and progenitor cells from healthy donors
(Master thesis, 2014-02-28)The thesis has the title Single cell analysis of signal transduction in hematopoietic stem and progenitor cells from healthy donors". Flow cytometry enables complex biochemical signaling networks to be determined in ... -
SLC25A51 is a mammalian mitochondrial NAD+ transporter
(Journal article; Peer reviewed, 2020)Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been identified in ... -
Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
(Peer reviewed; Journal article, 2014-01-21)Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic ... -
Specificity of commonly used cyclic nucleotides with PKA, PKG and Epac-implementing microcalorimetry to determine PDE activities
(Conference object, 2007-07-25) -
Stability and flexibility of full-length human oligodendrocytic QKI6
(Peer reviewed; Journal article, 2019-09-23)Objective: Oligodendrocytes account for myelination in the central nervous system. During myelin compaction, key proteins are translated in the vicinity of the myelin membrane, requiring targeted mRNA transport. Quaking ... -
Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme
(Peer reviewed; Journal article, 2016-07-27)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural, and regulatory levels, and the preparation of ...