Blar i Department of Biomedicine på tittel
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C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer
(Journal article; Peer reviewed, 2022)Epidemiological studies have established a positive association between obesity and the incidence of postmenopausal breast cancer. Moreover, it is known that obesity promotes stem cell-like properties of breast cancer ... -
Cabozantinib is effective in melanoma brain metastasis cell lines and affects key signaling pathways
(Journal article; Peer reviewed, 2021-11-14)Melanomas have a high potential to metastasize to the brain. Recent advances in targeted therapies and immunotherapies have changed the therapeutical landscape of extracranial melanomas. However, few patients with melanoma ... -
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
(Peer reviewed; Journal article, 2009-11-13)Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ... -
Cancer stem cells as mediators of treatment resistance in brain tumors: Status and controversies
(Peer reviewed; Journal article, 2007-11)Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumorrelated mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and ... -
Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins
(Peer reviewed; Journal article, 2019)The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM) macromolecules filled with a collection of cells including cancer-associated fibroblasts (CAFs), blood vessel associated smooth muscle ... -
A candidate gene investigation of methylphenidate response in adult attention-deficit/hyperactivity disorder patients: results from a naturalistic study
(Peer reviewed; Journal article, 2016-08)Attention-deficit/hyperactivity disorder (ADHD) is a common childhood onset neuropsychiatric disorder with a complex and heterogeneous symptomatology. Persistence of ADHD symptoms into adulthood is common. Methylphenidate ... -
Capacitance measurement of dendritic exocytosis in an electrically coupled inhibitory retinal interneuron: an experimental and computational study
(Peer reviewed; Journal article, 2019-08-04)Exocytotic release of neurotransmitter can be quantified by electrophysiological recording from postsynaptic neurons. Alternatively, fusion of synaptic vesicles with the cell membrane can be measured as increased capacitance ... -
Catestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum
(Peer reviewed; Journal article, 2010-02-23)Catestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. We have tested the activities of catestatin and other related peptides on ... -
CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
(Journal article; Peer reviewed, 2022)Melanomas frequently metastasize to the brain. Despite recent progress in the treatment of melanoma brain metastasis, therapy resistance and relapse of disease remain unsolved challenges. CCT196969 is a SRC family kinase ... -
Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action
(Peer reviewed; Journal article, 2015-10-22)Okadaic acid (OA) and microcystin (MC) as well as several other microbial toxins like nodularin and calyculinA are known as tumor promoters as well as inducers of apoptotic cell death. Their intracellular targets are the ... -
CellSegm - a MATLAB toolbox for high-throughput 3D cell segmentation
(Peer reviewed; Journal article, 2013-08-09)The application of fluorescence microscopy in cell biology often generates a huge amount of imaging data. Automated whole cell segmentation of such data enables the detection and analysis of individual cells, where a manual ... -
Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma
(Peer reviewed; Journal article, 2017-09-25)The transcription factor ZEB1 has gained attention in tumor biology of epithelial cancers because of its function in epithelial-mesenchymal transition, DNA repair, stem cell biology and tumor-induced immunosuppression, but ... -
Cellular Host Responses to Gliomas
(Peer reviewed; Journal article, 2012-04-23)Background: Glioblastoma multiforme (GBM) is the most aggressive type of malignant primary brain tumors in adults. Molecular and genetic analysis has advanced our understanding of glioma biology, however mapping the cellular ... -
Cellular responses to metabolic stress. A study on the role of mitochondria in the crosstalk between cell metabolism and survival signaling
(Doctoral thesis, 2012-08-31)Metabolic imbalance is associated with increased risk of several diseases, including cancer. Metabolism affects or is affected by virtually all other cellular processes, which is not surprising considering their conserved ... -
Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis
(Journal article; Peer reviewed, 2021-02-18)Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease ... -
Challenges and Prospects for Designer T and NK Cells in Glioblastoma Immunotherapy
(Journal article; Peer reviewed, 2021)Glioblastoma (GBM) is the most prevalent, aggressive primary brain tumour with a dismal prognosis. Treatment at diagnosis has limited efficacy and there is no standardised treatment at recurrence. New, personalised treatment ... -
Characterisation of Immunoglobulin--IgG Responses During Combination Therapy of Chronic Hepatits-C Virus Infection
(Master thesis, 2009-06-02)Current recommended treatment of chronic hepatitis C is the combination of peg interferon and ribavirin. Ribavirin has shown that it poses both direct and indirect action mechanisms against several DNA and RNA viruses. ... -
The Characterization of Disordered Membrane-Binding Proteins of Myelin. A Biophysical Approach
(Doctoral thesis, 2019-04-12)Myelin is a multilayered lipid-rich structure that surrounds selected axonal segments in the central and peripheral nervous systems (CNS and PNS, respectively). Myelin insulates axons, which increases nerve conduction ... -
Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism
(Journal article; Peer reviewed, 2021)Porphobilinogen deaminase (PBGD), the third enzyme in the heme biosynthesis, catalyzes the sequential coupling of four porphobilinogen (PBG) molecules into a heme precursor. Mutations in PBGD are associated with acute ... -
Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes
(Peer reviewed; Journal article, 2019-08-01)Hassallidins are cyclic glycolipopeptides produced by cyanobacteria and other prokaryotes. The hassallidin structure consists of a peptide ring of eight amino acids where a fatty acid chain, additional amino acids, and ...