Blar i Department of Biomedicine på tittel
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Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins
(Peer reviewed; Journal article, 2018-06-25)Background: Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-specific ... -
Structure and function of an atypical homodimeric actin capping protein from the malaria parasite
(Journal article; Peer reviewed, 2022)Apicomplexan parasites, such as Plasmodium spp., rely on an unusual actomyosin motor, termed glideosome, for motility and host cell invasion. The actin filaments are maintained by a small set of essential regulators, which ... -
Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase
(Journal article; Peer reviewed, 2021)Pyridoxal 5́-phosphate (PLP) is an important cofactor for amino acid decarboxylases with many biological functions, including the synthesis of signalling molecules, such as serotonin, dopamine, histamine, γ-aminobutyric ... -
Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment
(Journal article; Peer reviewed, 2020)The functions of the annexin family of proteins involve binding to Ca2+, lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long ... -
Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations
(Journal article; Peer reviewed, 2021)Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure ... -
Structure of the mouse acidic amino acid decarboxylase GADL1
(Journal article; Peer reviewed, 2018)Pyridoxal 5′-phosphate (PLP) is a ubiquitous cofactor in various enzyme classes, including PLP-dependent decarboxylases. A recently discovered member of this class is glutamic acid decarboxylase-like protein 1 (GADL1), ... -
Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains
(Journal article; Peer reviewed, 2021)Prolyl 4-hydroxylases (P4Hs) catalyze post-translational hydroxylation of peptidyl proline residues. In addition to collagen P4Hs and hypoxia-inducible factor P4Hs, a third P4H—the poorly characterized endoplasmic ... -
Structure to function analysis with antigenic characterization of a hypothetical protein, HPAG1_0576 from Helicobacter pylori HPAG1
(Peer reviewed; Journal article, 2019-07-31)Helicobacter pylori, a unique gastric pathogen causing chronic inflammation in the gastric mucosa with a possibility to develop gastric cancer has one-third of its proteins still uncharacterized. In this study, a hypothetical ... -
Structure-based Druggability Predictions of RNA Binding Sites and Design of RNA Ligands
(Doctoral thesis, 2022-09-15)Den post-antibotiske æraen truer og for å møte denne krisen trengs det tilgang til nye klasser av antibiotika. Ribvoswitcher er cis-genregulerende foldete strukturer av ikke-kodende RNA, som handler gjennom konformasjonsendringer ... -
Studies of α11β1 integrin in the mouse and human periodontal ligament
(Doctoral thesis, 2009-06-12) -
Studies on viral gene transfer and angiogenesis inhibition in experimental glioma models
(Doctoral thesis, 2006-11-03) -
Study of the role of skin lymphatics in electrolyte and blood pressure regulation
(Doctoral thesis, 2020-02-21)Cardiovascular diseases are the major cause of death worldwide and represent a dramatic socio-economic challenge. Hypertension accounts for 18% of cardiovascular disease deaths in the Western countries, and is a major risk ... -
A study on features and markers of cellular metabolic rewiring
(Doctoral thesis, 2019-02-15)Mammalian cells regulate energy metabolism through molecular responses linked to the microenvironment and nutrient supply. Context dependent abnormalities of energy metabolism are important in disorders such as cancer, ... -
A study on metabolic rewiring in cancer cell plasticity
(Doctoral thesis, 2020-08-21)Adaptation of cellular energetics is an important feature of tumorigenesis as a vast supply of nutrients is needed to accommodate increased growth. Essential energy pathways includes glucose, fatty acid and amino acid ... -
The styryl benzoic acid derivative DC10 potentiates radiotherapy by targeting the xCT-glutathione axis
(Journal article; Peer reviewed, 2022)Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to ... -
Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites
(Peer reviewed; Journal article, 2019-08-22)Myelin protein 2 (P2) is a peripheral membrane protein of the vertebrate nervous system myelin sheath, having possible roles in both lipid transport and 3D molecular organization of the multilayered myelin membrane. We ... -
Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites
(Peer reviewed; Journal article, 2019-08-22)Myelin protein 2 (P2) is a peripheral membrane protein of the vertebrate nervous system myelin sheath, having possible roles in both lipid transport and 3D molecular organization of the multilayered myelin membrane. We ... -
Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein
(Peer reviewed; Journal article, 2010-11-21)Background The promyelocytic leukemia (PML) protein participates in a number of cellular processes, including transcription regulation, apoptosis, differentiation, virus defense and genome maintenance. This protein is ... -
Suicide gene therapy for the treatment of high-grade glioma: past lessons, present trends, and future prospects
(Journal article; Peer reviewed, 2020)Suicide gene therapy has represented an experimental cancer treatment modality for nearly 40 years. Among the various cancers experimentally treated by suicide gene therapy, high-grade gliomas have been the most prominent ...