Blar i Department of Biomedicine på tittel
Viser treff 624-643 av 710
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Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations
(Journal article; Peer reviewed, 2021)Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure ... -
Structure of the mouse acidic amino acid decarboxylase GADL1
(Journal article; Peer reviewed, 2018)Pyridoxal 5′-phosphate (PLP) is a ubiquitous cofactor in various enzyme classes, including PLP-dependent decarboxylases. A recently discovered member of this class is glutamic acid decarboxylase-like protein 1 (GADL1), ... -
Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains
(Journal article; Peer reviewed, 2021)Prolyl 4-hydroxylases (P4Hs) catalyze post-translational hydroxylation of peptidyl proline residues. In addition to collagen P4Hs and hypoxia-inducible factor P4Hs, a third P4H—the poorly characterized endoplasmic ... -
Structure to function analysis with antigenic characterization of a hypothetical protein, HPAG1_0576 from Helicobacter pylori HPAG1
(Peer reviewed; Journal article, 2019-07-31)Helicobacter pylori, a unique gastric pathogen causing chronic inflammation in the gastric mucosa with a possibility to develop gastric cancer has one-third of its proteins still uncharacterized. In this study, a hypothetical ... -
Structure-based Druggability Predictions of RNA Binding Sites and Design of RNA Ligands
(Doctoral thesis, 2022-09-15)Den post-antibotiske æraen truer og for å møte denne krisen trengs det tilgang til nye klasser av antibiotika. Ribvoswitcher er cis-genregulerende foldete strukturer av ikke-kodende RNA, som handler gjennom konformasjonsendringer ... -
Studies of α11β1 integrin in the mouse and human periodontal ligament
(Doctoral thesis, 2009-06-12) -
Studies on viral gene transfer and angiogenesis inhibition in experimental glioma models
(Doctoral thesis, 2006-11-03) -
Study of the role of skin lymphatics in electrolyte and blood pressure regulation
(Doctoral thesis, 2020-02-21)Cardiovascular diseases are the major cause of death worldwide and represent a dramatic socio-economic challenge. Hypertension accounts for 18% of cardiovascular disease deaths in the Western countries, and is a major risk ... -
A study on features and markers of cellular metabolic rewiring
(Doctoral thesis, 2019-02-15)Mammalian cells regulate energy metabolism through molecular responses linked to the microenvironment and nutrient supply. Context dependent abnormalities of energy metabolism are important in disorders such as cancer, ... -
A study on metabolic rewiring in cancer cell plasticity
(Doctoral thesis, 2020-08-21)Adaptation of cellular energetics is an important feature of tumorigenesis as a vast supply of nutrients is needed to accommodate increased growth. Essential energy pathways includes glucose, fatty acid and amino acid ... -
The styryl benzoic acid derivative DC10 potentiates radiotherapy by targeting the xCT-glutathione axis
(Journal article; Peer reviewed, 2022)Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to ... -
Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites
(Peer reviewed; Journal article, 2019-08-22)Myelin protein 2 (P2) is a peripheral membrane protein of the vertebrate nervous system myelin sheath, having possible roles in both lipid transport and 3D molecular organization of the multilayered myelin membrane. We ... -
Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites
(Peer reviewed; Journal article, 2019-08-22)Myelin protein 2 (P2) is a peripheral membrane protein of the vertebrate nervous system myelin sheath, having possible roles in both lipid transport and 3D molecular organization of the multilayered myelin membrane. We ... -
Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein
(Peer reviewed; Journal article, 2010-11-21)Background The promyelocytic leukemia (PML) protein participates in a number of cellular processes, including transcription regulation, apoptosis, differentiation, virus defense and genome maintenance. This protein is ... -
Suicide gene therapy for the treatment of high-grade glioma: past lessons, present trends, and future prospects
(Journal article; Peer reviewed, 2020)Suicide gene therapy has represented an experimental cancer treatment modality for nearly 40 years. Among the various cancers experimentally treated by suicide gene therapy, high-grade gliomas have been the most prominent ... -
Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy
(Peer reviewed; Journal article, 2017)Surgical resection is a standard component of treatment in the clinical management of patients with glioblastoma multiforme (GBM). However, experimental therapies are rarely investigated in the context of tumor debulking ... -
Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors
(Journal article; Peer reviewed, 2022)Background Glioblastomas are highly resistant to therapy, and virtually all patients experience tumor recurrence after standard-of-care treatment. Surgical tumor resection is a cornerstone in glioblastoma therapy, but its ... -
Survival in a consecutive series of 467 glioblastoma patients: Association with prognostic factors and treatment at recurrence at two independent institutions
(Journal article; Peer reviewed, 2023-02-02)Therapy of recurrent glioblastoma (GBM) is challenging due to lack of standard treatment. We investigated physicians’ treatment choice at recurrence and prognostic and predictive factors for survival in GBM patients from ... -
Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics
(Peer reviewed; Journal article, 2010-06-01)Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers in man. Despite technological advances in surgical management, combined regimens of radiotherapy with ...