Now showing items 314-333 of 479

    • NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo 

      Pai, Balagopal; Siripornmongcolchai, Taweeporn; Berentsen, Birgitte; Pakzad, Ashraf; Vieuille, Christel Marie; Pallesen, Ståle; Pajak, Maciej; Simpson, T. Ian; Armstrong, J. Douglas; Wibrand, Karin; Bramham, Clive R. (Peer reviewed; Journal article, 2014-01-13)
      microRNAs (miRNAs) are major regulators of protein synthesis in the brain. A major goal is to identify changes in miRNA expression underlying protein synthesis-dependent forms of synaptic plasticity such as long-term ...
    • No Protection against DSS-induced Colitis by Short-term Pretreatment with Seal or Fish Oils in Rats 

      Arslan, Gülen; Erichsen, Kari; Milde, Anne Marita; Helgeland, Lars; Bjørkkjær, Tormod; Frøyland, Livar; Berstad, Arnold (Peer reviewed; Journal article, 2007-04-30)
      Background: Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have modulating effects in several chronic infl ammatory conditions. The aim of the present study was to test whether prior short-term dietary supplementation ...
    • Normalized gradient fields for nonlinear motion correction of DCE-MRI time series 

      Hodneland, Erlend; Lundervold, Arvid; Rørvik, Jarle; Munthe-Kaas, Antonella Zanna (Peer reviewed; Journal article, 2014-04)
      Dynamic MR image recordings (DCE-MRI) of moving organs using bolus injections create two differenttypes of dynamics in the images: (i) spatial motion artifacts due to patient movements, breathing andphysiological pulsations ...
    • A novel GFP nude rat model to investigate tumor-stroma interactions 

      Yang, Ning; Huang, Bin; Tsinkalovsky, Oleg; Brekkå, Narve; Zhu, Huaiyang; Leiss, Lina; Enger, Per Øyvind; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2014-12-21)
      Backgroud: A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ...
    • Novel Insights into Integrin α11 Expression and Function 

      Alam, Jahedul (Doctoral thesis, 2020-01-31)
      Integrins are a major group of cell surface receptors, which link the extracellular matrix with the cell cytoskeleton. They are heterodimeric proteins consisting of non- covalently bound α- and β-subunits. By regulating ...
    • Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment 

      Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Zayats, Tetyana; Schork, Andrew J; Frei, Oleksandr; Bettella, Francesco; Witoelar, Aree; Li, Wen; Eriksen, Jon Alm; Krull, Florian; Djurovic, Srdjan; Faraone, Stephen V.; Reichborn-Kjennerud, Ted; Thompson, Wesley K; Johansson, Stefan; Haavik, Jan; Dale, Anders; Wang, Yunpeng; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018-02)
      Objective Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric condition. By exploiting the reported relationship between ADHD and educational attainment (EA), we aimed to improve ...
    • Novel method for isolating untouched rat natural killer cells with higher purity compared with positive selection and fluorescenceactivated cell sorting 

      Poli, Aurélie; Brons, Nicolaas H.C.; Ammerlaan, Wim; Michel, Tatiana; Hentges, François; Chekenya, Martha; Zimmer, Jacques (Peer reviewed; Journal article, 2010-11)
      Natural killer (NK) cells are important effectors of both innate and adaptive immune responses. Although human and mouse NK cells are extensively characterized, much less is known about the rat cells, partly because of the ...
    • Novel microscopy-based screening method reveals regulators of contact-dependent intercellular transfer 

      Frei, Dominik Michael; Hodneland, Erlend; Rios-Mondragon, Ivan; Burtey, Anne Pierrette; Neumann, B; Bulkescher, Jutta; Schölermann, Julia; Pepperkok, Rainer; Gerdes, Hans-Hermann; Kögel, Tanja (Peer reviewed; Journal article, 2015-08-14)
      Contact-dependent intercellular transfer (codeIT) of cellular constituents can have functional consequences for recipient cells, such as enhanced survival and drug resistance. Pathogenic viruses, prions and bacteria can ...
    • A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly 

      Ree, Rasmus Moen; Geithus, Anni Sofie; Tørring, Pernille Mathiesen; Sørensen, Kristina Pilekær; Damkjær, Mads; Lynch, Sally Ann; Arnesen, Thomas (Peer reviewed; Journal article, 2019-06-07)
      Background N-terminal acetylation is a common protein modification in human cells and is catalysed by N-terminal acetyltransferases (NATs), mostly cotranslationally. The NAA10-NAA15 (NatA) protein complex is the major NAT, ...
    • A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines 

      Aasen, Synnøve Nymark; Pospíšilová, Aneta; Eichler, Tilo Wolf; Pánek, Jiří; Hrubý, Martin; Štěpánek, Petr; Spriet, Endy; Jirák, Daniel; Skaftnesmo, Kai Ove; Thorsen, Frits (Peer reviewed; Journal article, 2015-09-08)
      To facilitate efficient drug delivery to tumor tissue, several nanomaterials have been designed, with combined diagnostic and therapeutic properties. In this work, we carried out fundamental in vitro and in vivo experiments ...
    • Novel Points of Attack for Targeted Cancer Therapy 

      Røsland, Gro Vatne; Engelsen, Agnete Svendsen Tennfjord (Peer reviewed; Journal article, 2014-10-30)
      New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...
    • Novel Points of Attack for Targeted Cancer Therapy 

      Røsland, Gro Vatne; Engelsen, Agnete Svendsen Tenfjord (Peer reviewed; Journal article, 2015-01)
      New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...
    • Nuclear Receptor Genes - Regulation and Evolution 

      Sharma, Yogita (Doctoral thesis, 2016-02-26)
      Nuclear receptors are transcription factors that typically bind ligands in order to regulate the expression level of their target genes. Members of this family work with their co-regulators and repressors to maintain a ...
    • Nutritional properties of protein sources on diet-induced obesity, hepatic lipid accumulation, and fatty acid composition in mice 

      Fauske, Kristin Røen (Doctoral thesis, 2018-10-26)
      The prevalence of obesity has increased rapidly, and excess adiposity is associated with comorbidities that increase the risk of mortality. An energy-dense diet that is high in sugar and fat is one of the major explanations ...
    • Occupational issues of adults with ADHD 

      Adamou, Marios; Arif, Muhammad; Asherson, Philip; Aw, Tar-Ching; Bolea, Blanca; Coghill, David; Guðjónsson, Gísli; Halmøy, Anne; Hodgkins, Paul; Müller, Ulrich; Pitts, Mark; Trakoli, Anna; Williams, Nerys; Young, Susan (Peer reviewed; Journal article, 2013-02-17)
      Background: ADHD is a common neurodevelopmental disorder that persists into adulthood. Its symptoms cause impairments in a number of social domains, one of which is employment. We wish to produce a consensus statement on ...
    • OLS Client and OLS Dialog: Open source tools to annotate public omics datasets 

      Perez-Riverol, Yasset; Ternent, Tobias; Koch, Maximilian; Barsnes, Harald; Vrousgou, Olga; Jupp, Simon; Vizcaíno, Juan Antonio (Peer reviewed; Journal article, 2017)
      The availability of user‐friendly software to annotate biological datasets and experimental details is becoming essential in data management practices, both in local storage systems and in public databases. The Ontology ...
    • On the Effect of DCE MRI Slice Thickness and Noise on Estimated Pharmacokinetic Biomarkers – A Simulation Study 

      Jurek, Jakub; Reisæter, Lars Anders Rokne; Kocinski, Marek; Materka, Andrzej (Journal article; Peer reviewed, 2020)
      Simulation of a dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) multiple sclerosis brain dataset is described. The simulated images in the implemented version have 1×1×1mm3 voxel resolution and arbitrary ...
    • Online interactive analysis of protein structure ensembles with Bio3D-web 

      Skjærven, Lars; Jariwala, Shashank; Yao, Xin-Qiu; Grant, Barry J. (Peer reviewed; Journal article, 2016-11)
      Bio3D-web is an online application for analyzing the sequence, structure and conformational heterogeneity of protein families. Major functionality is provided for identifying protein structure sets for analysis, their ...
    • An overview of deep learning in medical imaging focusing on MRI 

      Lundervold, Alexander Selvikvåg; Lundervold, Arvid (Peer reviewed; Journal article, 2018-12-13)
      What has happened in machine learning lately, and what does it mean for the future of medical image analysis? Machine learning has witnessed a tremendous amount of attention over the last few years. The current boom started ...
    • An overview on G protein-coupled receptor-induced signal transduction in acute myeloid leukemia 

      Selheim, Frode; Aasebø, Elise; Ribas, Catalina; Aragay, Anna M. (Peer reviewed; Journal article, 2019)
      Background: Acute Myeloid Leukemia (AML) is a genetically heterogeneous disease characterized by uncontrolled proliferation of precursor myeloid-lineage cells in the bone marrow. AML is also characterized by patients with ...